Association Between Tumor Necrosis Factor Inhibitors and the Risk of Hospitalization or Death Among Patients With Immune-Mediated Inflammatory Disease and COVID-19
Izadi Z, Brenner E, Mahil S, Dand N, Yiu Z, Yates M, Ungaro R, Zhang X, Agrawal M, Colombel J, Gianfrancesco M, Hyrich K, Strangfeld A, Carmona L, Mateus E, Lawson-Tovey S, Klingberg E, Cuomo G, Caprioli M, Cruz-Machado A, Mazeda Pereira A, Hasseli R, Pfeil A, Lorenz H, Hoyer B, Trupin L, Rush S, Katz P, Schmajuk G, Jacobsohn L, Seet A, Al Emadi S, Wise L, Gilbert E, Duarte-García A, Valenzuela-Almada M, Isnardi C, Quintana R, Soriano E, Hsu T, D’Silva K, Sparks J, Patel N, Xavier R, Marques C, Kakehasi A, Flipo R, Claudepierre P, Cantagrel A, Goupille P, Wallace Z, Bhana S, Costello W, Grainger R, Hausmann J, Liew J, Sirotich E, Sufka P, Robinson P, Machado P, Griffiths C, Barker J, Smith C, Yazdany J, Kappelman M, Bachelez H, Capon F, Coker B, De La Cruz C, Mason K, Di Meglio P, Gelfand J, Gisondi P, Iversen L, Jullien D, Lambert J, Langan S, McAteer H, Meynell F, Moorhead L, Naldi L, Puig L, Reynolds N, Spuls P, Torres T, Tsakok T, Vincent A, Warren R, Waweru H, Ng S, Gearry R, Reinisch W, Rahier J, Lewis J, Kaplan G, Steinwurz F, Kissous-Hunt M, Modesto I, Konings M, Dahou B, Gómez G, Roberts K, Baez R, Castro Coello V, Haye Salinas M, Maldonado F, Reyes A, Alle G, Tanten R, Maldonado Ficco H, Nieto R, Gobbi C, Tissera Y, Pisoni C, Paula A, Albiero J, Schmid M, Cosatti M, Gamba M, Leandro C, Cusa M, German N, Bellomio V, Takashima L, Pera M, Cogo K, Gálvez Elkin M, Medina M, Savio V, Rojas Tessel R, Alamino R, Werner M, Ornella S, Casalla L, de la Vega M, Severina M, García M, Gonzalez Lucero L, Romeo C, Moyano S, Barbich T, Bertoli A, Baños A, Petruzzelli S, Matellan C, Conti S, Lazaro M, Rodriguez Gil G, Risueño F, Quaglia M, Scafati J, Cuchiaro N, Rebak J, Pineda S, Calvo M, Picco E, Yanzi J, Maid P, Guaglianone D, Morbiducci J, Porta S, Herscovich N, Velasco Zamora J, Kisluk B, Castaños Menescardi M, Gallo R, Martire M, Maldini C, Goizueta C, de la Vega Fernandez S, Aeschlimann C, Subils G, Rath E, Piette Y, Devinck M, Maeyaert B, Machado Ribeiro F, Euzebio Ribeiro S, Pinheiro M, Ibáñez S, Chassin Trubert A, Dong L, Cajas L, Barešić M, Anić B, Čulo M, Pavelić T, Stranski K, Karanovic B, Vencovsky J, Píchová M, Filkova M, Hamoud H, Vassilopoulos D, Guzman Melgar G, So H, Király M, Vojdanian M, Balbir Gurman A, Abutiban F, Zepa J, Bulina I, Bukauskiene L, Zazueta Montiel B, Castillo Ortiz A, Zamora Tehozol E, Vega Morales D, Cervántes Rosete D, Martín Nares E, Rodriguez Reyna T, Rull Gabayet M, Alpízar Rodríguez D, Irazoque F, Jimenez X, Geurts van Bon L, Zijlstra T, Hoekstra M, Al Adhoubi N, Salim B, Giraldo E, Salinas A, Ugarte Gil M, Nowakowski J, Conway R, Flood R, McCarthy G, Felea I, Filipescu I, Rednic S, Groseanu L, Tamas M, Mlynarikova V, Skamlova M, Zlnay M, Mičeková D, Capova L, Macejova Z, Šteňová E, Raffayova H, Belakova G, Strakova E, Senčarová M, Žlnayová S, Sabová A, Spisakova D, Oetterová M, Lukacova O, Bakosova M, Hocevar A, de la Torre Rubio N, Alegre Sancho J, Corteguera Coro M, Cobeta Garcia J, Torres Martin M, Campos J, Gomez Puerta J, Yardımcı G, Akar S, Icacan O, ÇELİK S, Vasylets V, Yeoh S, Vandevelde C, Dunt S, Leeder J, Macphie E, Salerno R, Graver C, Williams K, O'Reilly S, Devine K, Tyler J, Warner E, Pilcher J, Patel S, Nikiphorou E, Chadwick L, Jones C, Harrison B, Thornton L, O'Kane D, Fusi L, Low A, Horton S, Jatwani S, Baig S, Bajwa H, Berglund V, Dahle A, Dorman W, Hargrove J, Hilton M, Lebedoff N, Leonard S, Morgan J, Pfeifer E, Skemp A, Wilson J, Wolff A, Cepeda E, Todd D, Hare D, Calabrese C, Adams C, Khosroshahi A, Kilian A, White D, Winter M, Fields T, Siegel C, Daver N, Harvey M, Kramer N, Lamore C, Hogarty S, Yeter K, Siddique F, Ban B, Tanner T, Ruderman E, Davis W, Quinet R, Scopelitis E, Toribio K, Webb Detiege T, Zakem J, Abbass K, Kepecs G, Miranda L, Guma M, Haikal A, Mody S, Mueller D, Jayatilleke A, Zell J, Bays A, Dao K, Ezzati F, Parks D, Karp D, Quiceno G. Association Between Tumor Necrosis Factor Inhibitors and the Risk of Hospitalization or Death Among Patients With Immune-Mediated Inflammatory Disease and COVID-19. JAMA Network Open 2021, 4: e2129639. PMID: 34661663, PMCID: PMC8524310, DOI: 10.1001/jamanetworkopen.2021.29639.Peer-Reviewed Original ResearchConceptsTNF inhibitor monotherapyCOVID-19-associated hospitalizationTumor necrosis factor inhibitorsNecrosis factor inhibitorsInhibitor monotherapyInflammatory bowel diseaseTNF inhibitorsCOVID-19 outcomesPooled analysisMethotrexate monotherapyImmunomodulatory treatmentMethotrexate therapyClinical characteristicsCohort studyBowel diseaseFactor inhibitorsInflammatory diseasesMAIN OUTCOMEAdverse COVID-19 outcomesCOVID-19Multivariable logistic regression modelMultilevel multivariable logistic regression modelsJAK inhibitor monotherapyKinase inhibitor monotherapyRisk of hospitalizationFactors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry
Strangfeld A, Schäfer M, Gianfrancesco M, Lawson-Tovey S, Liew J, Ljung L, Mateus E, Richez C, Santos M, Schmajuk G, Scirè C, Sirotich E, Sparks J, Sufka P, Thomas T, Trupin L, Wallace Z, Al-Adely S, Bachiller-Corral J, Bhana S, Cacoub P, Carmona L, Costello R, Costello W, Gossec L, Grainger R, Hachulla E, Hasseli R, Hausmann J, Hyrich K, Izadi Z, Jacobsohn L, Katz P, Kearsley-Fleet L, Robinson P, Yazdany J, Machado P, Dahou B, Pinheiro M, Ribeiro F, Chassin-Trubert A, Ibáñez S, Dong L, Cajas L, Hamoud H, Avouac J, Belin V, Borie R, Chazerain P, Chevalier X, Claudepierre P, Clavel G, Colette-Cedoz M, Combe B, Constant E, Costedoat-Chalumeau N, Desmurs M, Devauchelle-Pensec V, Devaux M, Dhote R, Dieudonné Y, Domont F, Duret P, Ebbo M, Ebstein E, Mahou S, Fautrel B, Felten R, Flipo R, Foltz V, Froissart A, Galland J, Gaud-Listrat V, Georgin-Lavialle S, Giraud-Morelet A, Quitrec J, Goupille P, Govindaraju-Audouard S, Grados F, Guillaume-Czitrom S, Hermet M, Hittinger-Roux A, Hudry C, Kone-Paut I, La Batide Alanore S, Lafforgue P, Lahalle S, Lambrecht I, Langlois V, Larbre J, Ledoult E, Leroux C, Liote F, Maria A, Marotte H, Mekinian A, Melki I, Messer L, Michel C, Morel G, Morel J, Paris-Havard M, Pertuiset E, Pham T, Renard M, Revuz S, Rivière S, Rousselin C, Roux C, Rouzaud D, Sellam J, Seror R, Servettaz A, Sobanski V, Sordet C, Spielmann L, Tieulié N, Tison A, Trijau S, Virone A, Warzocha U, Wendling D, Albach F, Aries P, Decker E, Hartmann U, Henes J, Hoyer B, Krause A, Krüger K, Lorenz H, Müller-Ladner U, Pfeil A, Regierer A, Richter J, Rihl M, Schmeiser T, Schulze-Koops H, Specker C, Voll R, Werner S, Melgar G, Vojdanian, Andreoli L, Bartoloni-Bocci E, Benucci M, Campanaro F, Caprioli M, Carboni D, Carrara G, Cipolletta E, Crotti C, Dallagiacoma G, Faggioli P, Foti R, Franceschini F, Fredi M, Guidelli G, Iannone F, Landolfi G, Lomater C, Nalli C, Parisi S, Quartuccio L, Raffeiner B, Reggia R, Riva M, Romeo N, Rotondo C, Silvagni E, Sinigaglia L, Tinazzi I, Zanetti A, Zanframundo G, Abutiban F, Alpízar-Rodríguez D, Rull-Gabayet M, Irazoque F, Jimenez X, Martín-Nares E, Castillo-Ortiz A, Rodriguez-Reyna T, Rosete D, Zamora-Tehozol E, Vega-Morales D, Zaueta-Montiel B, Al-Adhoubi N, Salim B, Giraldo E, Salinas A, Ugarte-Gil M, Almeida D, Bernardes M, Machado R, Rato M, Al-Emadi S, Conway R, Flood R, Alegre-Sancho J, Coro M, de la Torre-Rubio N, Esteban J, del Martin M, Puerta J, Back J, Dastmalchi M, Dupré B, Grenholm E, Hensvold A, Knight A, Akar S, Icacan O, Chadwick L, Devine K, Dunt S, Fusi L, Jones C, Macphie E, Nikiphorou E, O'Kane D, O'Reilly S, Patel S, Salerno R, Thornton L, Tyler J, Vandevelde C, Warner E, Yeoh S, Baig S, Bajwa H, Ban B, Berglund V, Calabrese C, D'Silva K, Dahle A, Dao K, Daver N, Davis W, Dorman W, Fatemeh E, Fields T, Hargrove J, Harvey M, Hilton M, Hsu T, Izadi Z, Jayatilleke A, Karp D, Kepecs G, Kramer N, Lamore C, Lebedoff N, Leonard S, Mody S, Morgan J, Pfeifer E, Quiceno G, Quinet R, Rosenstein E, Ruderman E, Scopelitis E, Serling-Boyd N, Siddique F, Skemp A, Sparks J, Todd D, Toribio K, Wallwork R, Webb-Detiege T, White D, Wilson J, Winter M, Wise L, Wolff A, Young K, Zakem J, Zell J, Zimmerman K. Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance physician-reported registry. Annals Of The Rheumatic Diseases 2021, 80: 930-942. PMID: 33504483, PMCID: PMC7843211, DOI: 10.1136/annrheumdis-2020-219498.Peer-Reviewed Original ResearchConceptsDisease-modifying anti-rheumatic drugsCOVID-19-related deathsHigh disease activityRheumatic diseasesDisease activityHigher oddsBiological disease-modifying anti-rheumatic drugsMultivariable logistic regression modelRegistry of adultsRheumatic disease diagnosisAnti-rheumatic drugsChronic lung diseaseDisease-specific factorsAdequate disease controlLogistic regression modelsGlucocorticoid dosageMethotrexate monotherapyPrimary outcomeSmoking statusMale sexLung diseaseCardiovascular diseaseIndependent factorsDisease categoriesDisease control