2023
Impact of Risk Factors on COVID‐19 Outcomes in Unvaccinated People With Rheumatic Diseases: A Comparative Analysis of Pandemic Epochs Using the COVID‐19 Global Rheumatology Alliance Registry
Yazdany J, Ware A, Wallace Z, Bhana S, Grainger R, Hachulla E, Richez C, Cacoub P, Hausmann J, Liew J, Sirotich E, Jacobsohn L, Strangfeld A, Mateus E, Hyrich K, Gossec L, Carmona L, Lawson‐Tovey S, Kearsley‐Fleet L, Schaefer M, Ribeiro S, Al‐Emadi S, Hasseli R, Müller‐Ladner U, Specker C, Schulze‐Koops H, Bernardes M, Fraga V, Rodrigues A, Sparks J, Ljung L, Di Giuseppe D, Tidblad L, Wise L, Duarte‐García A, Ugarte‐Gil M, Colunga‐Pedraza I, Martínez‐Martínez M, Alpizar‐Rodriguez D, Xavier R, Isnardi C, Pera M, Pons‐Estel G, Izadi Z, Gianfrancesco M, Carrara G, Scirè C, Zanetti A, Machado P. Impact of Risk Factors on COVID‐19 Outcomes in Unvaccinated People With Rheumatic Diseases: A Comparative Analysis of Pandemic Epochs Using the COVID‐19 Global Rheumatology Alliance Registry. Arthritis Care & Research 2023, 76: 274-287. PMID: 37643903, DOI: 10.1002/acr.25220.Peer-Reviewed Original ResearchB-cell depleting therapySevere COVID-19Rheumatic diseasesCOVID-19 outcomesUnvaccinated peopleRisk factorsWorse outcomesCOVID-19Severe COVID-19 outcomesTumor necrosis factor inhibitorsHigh disease activityNecrosis factor inhibitorsConnective tissue diseaseCOVID-19 severityCOVID-19 vaccineThird of individualsLogistic regression modelsCOVID-19 diagnosisOrdinal logistic regression modelsLow HDI regionsMore comorbiditiesUnvaccinated patientsDisease activityUnvaccinated individualsFactor inhibitorsCharacteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis: data from the COVID-19 PsoProtect and Global Rheumatology Alliance physician-reported registries
Machado P, Schäfer M, Mahil S, Liew J, Gossec L, Dand N, Pfeil A, Strangfeld A, Regierer A, Fautrel B, Alonso C, Saad C, Griffiths C, Lomater C, Miceli-Richard C, Wendling D, Rodriguez D, Wiek D, Mateus E, Sirotich E, Soriano E, Ribeiro F, Omura F, Martins F, Santos H, Dau J, Barker J, Hausmann J, Hyrich K, Gensler L, Silva L, Jacobsohn L, Carmona L, Pinheiro M, Zelaya M, de los Ángeles Severina M, Yates M, Dubreuil M, Gore-Massy M, Romeo N, Haroon N, Sufka P, Grainger R, Hasseli R, Lawson-Tovey S, Bhana S, Pham T, Olofsson T, Bautista-Molano W, Wallace Z, Yiu Z, Yazdany J, Robinson P, Smith C. Characteristics associated with poor COVID-19 outcomes in people with psoriasis, psoriatic arthritis and axial spondyloarthritis: data from the COVID-19 PsoProtect and Global Rheumatology Alliance physician-reported registries. Annals Of The Rheumatic Diseases 2023, 82: 698-709. PMID: 36787993, PMCID: PMC10176347, DOI: 10.1136/ard-2022-223499.Peer-Reviewed Original ResearchConceptsSevere COVID-19High disease activityPandemic time periodDisease activityPsoriatic arthritisMale sexAxial spondyloarthritisCOVID-19Multivariable ordinal logistic regressionPoor COVID-19 outcomesOlder ageFuture respiratory pandemicsCOVID-19 severityCOVID-19 outcomesComorbidity burdenGlucocorticoid intakeGlucocorticoid useCancer comorbidityClinical characteristicsCOVID-19 waveRisk stratificationOrdinal logistic regressionReduced oddsSeverity ScaleRespiratory pandemic
2022
Association Between Race/Ethnicity and COVID‐19 Outcomes in Systemic Lupus Erythematosus Patients From the United States: Data From the COVID‐19 Global Rheumatology Alliance
Ugarte‐Gil M, Alarcón G, Seet A, Izadi Z, Montgomery A, Duarte‐García A, Gilbert E, Valenzuela‐Almada M, Wise L, Sparks J, Hsu T, D'Silva K, Patel N, Sirotich E, Liew J, Hausmann J, Sufka P, Grainger R, Bhana S, Wallace Z, Jacobsohn L, Strangfeld A, Mateus E, Hyrich K, Gossec L, Carmona L, Lawson‐Tovey S, Kearsley‐Fleet L, Schaefer M, Machado P, Robinson P, Gianfrancesco M, Yazdany J. Association Between Race/Ethnicity and COVID‐19 Outcomes in Systemic Lupus Erythematosus Patients From the United States: Data From the COVID‐19 Global Rheumatology Alliance. Arthritis Care & Research 2022, 75: 53-60. PMID: 36239292, PMCID: PMC9874592, DOI: 10.1002/acr.25039.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusCOVID-19 outcomesRace/ethnicitySevere COVID-19 outcomesSystemic lupus erythematosus patientsImmunosuppressive drug useLupus erythematosus patientsCOVID-19 severityUS general populationLogistic regression modelsOrdinal logistic regression modelsGlucocorticoid doseDisease activityPandemic time periodSD ageLupus erythematosusPossible confoundersSevere outcomesMultivariable modelHigher oddsGeneral populationPatientsDrug useHealth disparitiesOutcome categoriesCharacteristics and Outcomes of People With Gout Hospitalized Due to COVID‐19: Data From the COVID‐19 Global Rheumatology Alliance Physician‐Reported Registry
Jatuworapruk K, Montgomery A, Gianfrancesco M, Conway R, Durcan L, Graef E, Jayatilleke A, Keen H, Kilian A, Young K, Carmona L, Cogo A, Duarte‐García A, Gossec L, Hasseli R, Hyrich K, Langlois V, Lawson‐Tovey S, Malcata A, Mateus E, Schafer M, Scirè C, Sigurdardottir V, Sparks J, Strangfeld A, Xavier R, Bhana S, Gore‐Massy M, Hausmann J, Liew J, Sirotich E, Sufka P, Wallace Z, Machado P, Yazdany J, Grainger R, Robinson P. Characteristics and Outcomes of People With Gout Hospitalized Due to COVID‐19: Data From the COVID‐19 Global Rheumatology Alliance Physician‐Reported Registry. ACR Open Rheumatology 2022, 4: 948-953. PMID: 36000538, PMCID: PMC9539246, DOI: 10.1002/acr2.11495.Peer-Reviewed Original ResearchMore comorbiditiesVentilatory supportPoor outcomeCOVID-19COVID-19-related deathsChronic kidney diseasePresence of comorbiditiesCohort of peopleCOVID-19 outcomesCoronavirus disease 2019Outcomes of peopleMedication exposureOverall cohortVentilation supportDiabetes mellitusSupplemental oxygenKidney diseaseMean ageRisk factorsCardiovascular diseaseDisease 2019ComorbiditiesGoutCohortPatientsEnvironmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study
Izadi Z, Gianfrancesco M, Schmajuk G, Jacobsohn L, Katz P, Rush S, Ja C, Taylor T, Shidara K, Danila M, Wysham K, Strangfeld A, Mateus E, Hyrich K, Gossec L, Carmona L, Lawson-Tovey S, Kearsley-Fleet L, Schaefer M, Al-Emadi S, Sparks J, Hsu T, Patel N, Wise L, Gilbert E, Duarte-García A, Valenzuela-Almada M, Ugarte-Gil M, Ljung L, Scirè C, Carrara G, Hachulla E, Richez C, Cacoub P, Thomas T, Santos M, Bernardes M, Hasseli R, Regierer A, Schulze-Koops H, Müller-Ladner U, Pons-Estel G, Tanten R, Nieto R, Pisoni C, Tissera Y, Xavier R, Marques C, Pileggi G, Robinson P, Machado P, Sirotich E, Liew J, Hausmann J, Sufka P, Grainger R, Bhana S, Gore-Massy M, Wallace Z, Yazdany J, Registry C, Dahou B, Gómez G, Roberts K, Baez R, Coello V, Salinas M, Maldonado F, Reyes A, Alle G, Tanten R, Ficco H, Nieto R, Gobbi C, Tissera Y, Pisoni C, Paula A, Albiero J, Schmid M, Cosatti M, Gamba M, Leandro C, Cusa M, German N, Bellomio V, Takashima L, Pera M, Cogo K, Elkin M, Medina M, Savio V, Tessel R, Alamino R, Werner M, Ornella S, Casalla L, de la Vega M, Severina M, García M, Lucero L, Romeo C, Moyano S, Barbich T, Bertoli A, Baños A, Petruzzelli S, Matellan C, Conti S, Lazaro M, Gil G, Risueño F, Quaglia M, Scafati J, Cuchiaro N, Rebak J, Pineda S, Calvo M, Picco E, Yanzi J, Maid P, Guaglianone D, Morbiducci J, Porta S, Herscovich N, Zamora J, Kisluk B, Menescardi M, Gallo R, Martire M, Maldini C, Goizueta C, de la Vega Fernandez S, Aeschlimann C, Subils G, Rath E, Piette Y, Devinck M, Maeyaert B, Ribeiro F, Ribeiro S, Pinheiro M, Ibáñez S, Trubert A, Dong L, Cajas L, Barešić M, Anić B, Ćulo M, Pavelić T, Stranski K, Karanovic B, Vencovsky J, Píchová M, Filkova M, Hamoud H, Vassilopoulos D, Melgar G, So H, Király M, Vojdanian, Gurman A, Abutiban F, Zepa J, Bulina I, Bukauskiene L, Montiel B, Ortiz A, Tehozol E, Morales D, Rosete D, Nares E, Reyna T, Gabayet M, Rodríguez D, Irazoque F, Jimenez X, van Bon L, Zijlstra T, Hoekstra M, Al Adhoubi N, Salim B, Giraldo E, Salinas A, Gil M, Nowakowski J, Conway R, Flood R, McCarthy G, Felea I, Filipescu I, Rednic S, Groseanu L, Tamas M, Mlynarikova V, Skamlova M, Zlnay M, Mičeková D, Capova L, Macejova Z, Šteňová E, Raffayova H, Belakova G, Strakova E, Senčarová M, Žlnayová S, Sabová A, Spisakova D, Oetterová M, Lukacova O, Bakosova M, Hocevar A, de la Torre Rubio N, Sancho J, Coro M, Garcia J, Martin M, Campos J, Puerta J, Yardimci G, Akar S, Icacan O, ÇELİK S, Vasylets V, Yeoh S, Vandevelde C, Dunt S, Leeder J, Macphie E, Salerno R, Graver C, Williams K, O'Reilly S, Devine K, Tyler J, Warner E, Pilcher J, Patel S, Nikiphorou E, Chadwick L, Jones C, Harrison B, Thornton L, O'Kane D, Fusi L, Low A, Horton S, Jatwani S, Baig S, Bajwa H, Berglund V, Dahle A, Dorman W, Hargrove J, Hilton M, Lebedoff N, Leonard S, Morgan J, Pfeifer E, Skemp A, Wilson J, Wolff A, Cepeda E, Todd D, Hare D, Calabrese C, Adams C, Khosroshahi A, Kilian A, White D, Winter M, Fields T, Siegel C, Daver N, Harvey M, Kramer N, Lamore C, Hogarty S, Yeter K, Siddique F, Ban B, Tanner T, Ruderman E, Davis W, Quinet R, Scopelitis E, Toribio K, Detiege T, Zakem J, Abbass K, Kepecs G, Miranda L, Guma M, Haikal A, Mody S, Mueller D, Jayatilleke A, Zell J, Bays A, Dao K, Ezzati F, Parks D, Karp D, Quiceno G. Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study. The Lancet Rheumatology 2022, 4: e603-e613. PMID: 35909441, PMCID: PMC9313519, DOI: 10.1016/s2665-9913(22)00192-8.Peer-Reviewed Original ResearchRheumatic diseasesCOVID-19 outcomesRisk factorsObservational studyCOVID-19COVID-19-related deathsClinical risk factorsMultivariable logistic regressionCOVID-19 severity levelsIndividual-level risk factorsPrimary endpointMean ageIndependent associationHigher oddsAmerican CollegeLower oddsLogistic regressionHospital bedsMortalityDiseaseSocietal factorsMixed effects modelsDeathRheumatologyAssociationOP0252 FACTORS ASSOCIATED WITH SEVERE COVID-19 OUTCOMES IN PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHY: RESULTS FROM THE COVID-19 GLOBAL RHEUMATOLOGY ALLIANCE PHYSICIAN-REPORTED REGISTRY
Yeoh S, Gianfrancesco M, Lawson-Tovey S, Hyrich K, Strangfeld A, Gossec L, Carmona L, Mateus E, Schaefer M, Richez C, Hachulla E, Holmqvist M, Scirè C, Hasseli R, Jayatilleke A, Hsu T, D’Silva K, Pimentel-Quiroz V, Vasquez del Mercado M, Katsuyuki Shinjo S, Reis Neto E, Rocha L, Montandon A, Jordan P, Sirotich E, Hausmann J, Liew J, Jacobsohn L, Gore-Massy M, Sufka P, Grainger R, Bhana S, Wallace Z, Robinson P, Yazdany J, Machado P. OP0252 FACTORS ASSOCIATED WITH SEVERE COVID-19 OUTCOMES IN PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHY: RESULTS FROM THE COVID-19 GLOBAL RHEUMATOLOGY ALLIANCE PHYSICIAN-REPORTED REGISTRY. Annals Of The Rheumatic Diseases 2022, 81: 165-166. DOI: 10.1136/annrheumdis-2022-eular.3235.Peer-Reviewed Original ResearchIdiopathic inflammatory myopathiesIdiopathic inflammatory myopathy patientsHigh disease activityDisease activityOdds ratioGrant/research supportAstra ZenecaInflammatory myopathiesSynthetic DMARDsCOVID-19 severity scaleCOVID-19 outcomesBristol-Myers SquibbMultivariate logistic regression analysis of factorsBoehringer IngelheimDisease-modifying anti-rheumatic drugsIIM casesSanofi GenzymeAssociated with worse outcomesFactors associated with severe COVID-19 outcomesMultivariate logistic regression analysisExposure to rituximabOutcomes of patientsConventional synthetic DMARDsAnti-rheumatic drugsLogistic regression analysis of factorsOP0249 CHARACTERISTICS ASSOCIATED WITH POOR COVID-19 OUTCOMES IN PEOPLE WITH PSORIASIS AND SPONDYLOARTHRITIS: DATA FROM THE COVID-19 PsoProtect AND GLOBAL RHEUMATOLOGY ALLIANCE PHYSICIAN-REPORTED REGISTRIES
Machado P, Schaefer M, Mahil S, Dand N, Gianfrancesco M, Lawson-Tovey S, Yiu Z, Yates M, Hyrich K, Gossec L, Carmona L, Mateus E, Wiek D, Bhana S, Gore-Massy M, Grainger R, Hausmann J, Sufka P, Sirotich E, Wallace Z, Olofsson T, Lomater C, Romeo N, Wendling D, Pham T, Miceli Richard C, Fautrel B, Silva L, Santos H, Martins F, Hasseli R, Pfeil A, Regierer A, Isnardi C, Soriano E, Quintana R, Omura F, Machado Ribeiro F, Pinheiro M, Bautista-Molano W, Alpizar-Rodriguez D, Saad C, Dubreuil M, Haroon N, Gensler L, Dau J, Jacobsohn L, Liew J, Strangfeld A, Barker J, Griffiths C, Robinson P, Yazdany J, Smith C. OP0249 CHARACTERISTICS ASSOCIATED WITH POOR COVID-19 OUTCOMES IN PEOPLE WITH PSORIASIS AND SPONDYLOARTHRITIS: DATA FROM THE COVID-19 PsoProtect AND GLOBAL RHEUMATOLOGY ALLIANCE PHYSICIAN-REPORTED REGISTRIES. Annals Of The Rheumatic Diseases 2022, 81: 163-164. DOI: 10.1136/annrheumdis-2022-eular.1753.Peer-Reviewed Original ResearchIL-23/IL-12High disease activitySevere COVID-19 outcomesDisease activityAssociated with severe COVID-19 outcomesCOVID-19 outcomesGlobal Rheumatology AllianceMale sexPooled analysis of dataFactors associated with severe COVID-19 outcomesDiagnosis of PsOPsoriasis patient registriesIL-17 inhibitorsAnti-rheumatic drugsOlder agePhysician-reported disease activityChronic kidney diseaseMultivariate ordinal logistic regression modelGC intakeIL-17iCOVID-19 severityActive diseaseSpecificity of patientsCOVID-19 Global Rheumatology AllianceAxial spondyloarthritisCharacteristics associated with poor COVID-19 outcomes in individuals with systemic lupus erythematosus: data from the COVID-19 Global Rheumatology Alliance
Ugarte-Gil M, Alarcón G, Izadi Z, Duarte-García A, Reátegui-Sokolova C, Clarke A, Wise L, Pons-Estel G, Santos M, Bernatsky S, Ribeiro S, Al Emadi S, Sparks J, Hsu T, Patel N, Gilbert E, Valenzuela-Almada M, Jönsen A, Landolfi G, Fredi M, Goulenok T, Devaux M, Mariette X, Queyrel V, Romão V, Sequeira G, Hasseli R, Hoyer B, Voll R, Specker C, Baez R, Castro-Coello V, Ficco H, Neto E, Ferreira G, Monticielo O, Sirotich E, Liew J, Hausmann J, Sufka P, Grainger R, Bhana S, Costello W, Wallace Z, Jacobsohn L, Taylor T, Ja C, Strangfeld A, Mateus E, Hyrich K, Carmona L, Lawson-Tovey S, Kearsley-Fleet L, Schäfer M, Machado P, Robinson P, Gianfrancesco M, Yazdany J. Characteristics associated with poor COVID-19 outcomes in individuals with systemic lupus erythematosus: data from the COVID-19 Global Rheumatology Alliance. Annals Of The Rheumatic Diseases 2022, 81: 970-978. PMID: 35172961, PMCID: PMC8882632, DOI: 10.1136/annrheumdis-2021-221636.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusCOVID-19 outcomesSevere outcomesDisease activityLupus erythematosusHigher SLE disease activityActive systemic lupus erythematosusMultivariable ordinal logistic regression modelsSevere COVID-19 outcomesPoor COVID-19 outcomesSLE disease activitySex-adjusted modelsMore severe outcomesCOVID-19 severityCOVID-19Logistic regression modelsOrdinal logistic regression modelsPrednisone doseMale sexGlobal RegistryWorse outcomesMultivariable modelCurrent treatmentComorbiditiesOlder age
2021
Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study
Sattui S, Conway R, Putman M, Seet A, Gianfrancesco M, Beins K, Hill C, Liew D, Mackie S, Mehta P, Neill L, Gomez G, Salinas M, Maldonado F, Mariz H, de Sousa Studart S, Araujo N, Knight A, Rozza D, Quartuccio L, Samson M, Bally S, Maria A, Chazerain P, Hasseli R, Müller-Ladner U, Hoyer B, Voll R, Torres R, Luis M, Ribeirio S, Al-Emadi S, Sparks J, Hsu T, D’Silva K, Patel N, Wise L, Gilbert E, Almada M, Duarte-García A, Ugarte-Gil M, Jacobsohn L, Izadi Z, Strangfeld A, Mateus E, Hyrich K, Gossec L, Carmona L, Lawson-Tovey S, Kearsley-Fleet L, Schaefer M, Sirotich E, Hausmann J, Sufka P, Bhana S, Liew J, Grainger R, Machado P, Wallace Z, Yazdany J, Robinson P, Alliance G, Dahou B, Rath E, Piette Y, Devinck M, Maeyaert B, Ribeiro F, Ribeiro S, Pinheiro M, Quintana R, Gómez G, Roberts K, Baez R, Coello V, Salinas M, Maldonado F, Torres A, Alle G, Tanten R, Ficco H, Nieto R, Gobbi C, Tissera Y, Pisoni C, Paula A, Albiero J, Schmid M, Cosatti M, Gamba M, Leandro C, Cusa M, German N, Bellomio V, Takashima L, Pera M, Cogo K, Elkin M, Medina M, Savio V, Tessel I, Alamino R, Werner M, Ornella S, Casalla L, de la Vega M, Severina M, García M, Lucero L, Romeo C, Moyano S, Barbich T, Bertoli A, Baños A, Petruzzelli S, Matellan C, Conti S, Lazaro M, Gil G, Risueño F, Quaglia M, Scafati J, Cuchiaro N, Rebak J, Pineda S, Calvo M, Picco E, Yanzi J, Maid P, Guaglianone D, Morbiducci J, Porta S, Herscovich N, Zamora J, Kisluk B, Menescardi M, Gallo R, Martire M, Maldini C, Goizueta C, de la Vega Fernandez S, Aeschlimann C, Subils G, Ibáñez S, Chassin-Trubert A, Dong L, Cajas L, Barešic M, Anic B, Culo M, Pavelic T, Stranski K, Karanovic B, Vencovsky J, Píchová M, Filkova M, Hamoud H, Vassilopoulos D, Melgar G, So H, Király M, Vojdanian, Balbir-Gurman A, Abutiban F, Zepa J, Bulina I, Bukauskiene L, Zaueta B, Ortiz A, Tehozol E, Vega D, Rosete D, Nares E, Rodriguez-Reyna T, Gabayet M, Alpízar-Rodríguez D, Irazoque F, Jimenez X, Bon L, Zijlstra T, Hoekstra M, Al-Adhoubi N, Salim B, Giraldo E, Salinas A, Ugarte-Gil M, Nowakowski J, Al-Emadi S, Conway R, Flood R, McCarthy G, Felea I, Filipescu I, Rednic S, Groseanu L, Tamas M, Mlynarikova V, Skamlova M, Zlnay M, Miceková D, Capova L, Macejova Z, Štenová E, Raffayova H, Belakova G, Strakova E, Sencarová M, Žlnayová S, Sabová A, Spisakova D, Oetterová M, Lukacova O, Bakosova M, Hocevar A, de la Torre-Rubio N, Sancho J, Coro M, Garcia J, Martin M, Campos J, Puerta J, Yardimci G, Akar S, Icacan O, Çelik S, Vasylets V, Yeoh S, Vandevelde C, Dunt S, Leeder J, Macphie E, Salerno R, Graver C, Williams K, O'Reilly S, Devine K, Tyler J, Warner E, Pilcher J, Patel S, Nikiphorou E, Chadwick L, Jones C, Harrison B, Thornton L, O'Kane D, Fusi L, Low A, Horton S, Jatwani S, Baig S, Bajwa H, Berglund V, Dahle A, Dorman W, Hargrove J, Hilton M, Lebedoff N, Leonard S, Morgan J, Pfeifer E, Skemp A, Wilson J, Wolff A, Cepeda E, D'Silva K, Hsu T, Patel N, Sparks J, Todd D, Wallace Z, Hare D, Calabrese C, Adams C, Khosroshahi A, Kilian A, White D, Winter M, Fields T, Siegel C, Daver N, Harvey M, Kramer N, Lamore C, Hogarty S, Yeter K, Wise L, Siddique F, Ban B, Tanner T, Ruderman E, Davis W, Quinet R, Scopelitis E, Toribio K, Webb-Detiege T, Zakem J, Abbass K, Kepecs G, Miranda L, Guma M, Haikal A, Mody S, Mueller D, Jayatilleke A, Zell J, Bays A, Dao K, Fatemeh E, Parks D, Karp D, Quiceno G. Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort study. The Lancet Rheumatology 2021, 3: e855-e864. PMID: 34778843, PMCID: PMC8570701, DOI: 10.1016/s2665-9913(21)00316-7.Peer-Reviewed Original ResearchPrimary systemic vasculitisCOVID-19 outcomesPoor COVID-19 outcomesNumber of comorbiditiesRetrospective cohort studySystemic vasculitisPolymyalgia rheumaticaSupplemental oxygenDisease activityCohort studyRisk factorsOdds ratioMultivariable ordinal logistic regression analysisSevere COVID-19 outcomesHigh-dose glucocorticoidsLow disease activitySevere disease activityGiant cell arteritisUnmodifiable risk factorsLogistic regression analysisOrdinal logistic regression analysisCOVID-19Eligible patientsGlucocorticoid useMore comorbiditiesAssociation Between Tumor Necrosis Factor Inhibitors and the Risk of Hospitalization or Death Among Patients With Immune-Mediated Inflammatory Disease and COVID-19
Izadi Z, Brenner E, Mahil S, Dand N, Yiu Z, Yates M, Ungaro R, Zhang X, Agrawal M, Colombel J, Gianfrancesco M, Hyrich K, Strangfeld A, Carmona L, Mateus E, Lawson-Tovey S, Klingberg E, Cuomo G, Caprioli M, Cruz-Machado A, Mazeda Pereira A, Hasseli R, Pfeil A, Lorenz H, Hoyer B, Trupin L, Rush S, Katz P, Schmajuk G, Jacobsohn L, Seet A, Al Emadi S, Wise L, Gilbert E, Duarte-García A, Valenzuela-Almada M, Isnardi C, Quintana R, Soriano E, Hsu T, D’Silva K, Sparks J, Patel N, Xavier R, Marques C, Kakehasi A, Flipo R, Claudepierre P, Cantagrel A, Goupille P, Wallace Z, Bhana S, Costello W, Grainger R, Hausmann J, Liew J, Sirotich E, Sufka P, Robinson P, Machado P, Griffiths C, Barker J, Smith C, Yazdany J, Kappelman M, Bachelez H, Capon F, Coker B, De La Cruz C, Mason K, Di Meglio P, Gelfand J, Gisondi P, Iversen L, Jullien D, Lambert J, Langan S, McAteer H, Meynell F, Moorhead L, Naldi L, Puig L, Reynolds N, Spuls P, Torres T, Tsakok T, Vincent A, Warren R, Waweru H, Ng S, Gearry R, Reinisch W, Rahier J, Lewis J, Kaplan G, Steinwurz F, Kissous-Hunt M, Modesto I, Konings M, Dahou B, Gómez G, Roberts K, Baez R, Castro Coello V, Haye Salinas M, Maldonado F, Reyes A, Alle G, Tanten R, Maldonado Ficco H, Nieto R, Gobbi C, Tissera Y, Pisoni C, Paula A, Albiero J, Schmid M, Cosatti M, Gamba M, Leandro C, Cusa M, German N, Bellomio V, Takashima L, Pera M, Cogo K, Gálvez Elkin M, Medina M, Savio V, Rojas Tessel R, Alamino R, Werner M, Ornella S, Casalla L, de la Vega M, Severina M, García M, Gonzalez Lucero L, Romeo C, Moyano S, Barbich T, Bertoli A, Baños A, Petruzzelli S, Matellan C, Conti S, Lazaro M, Rodriguez Gil G, Risueño F, Quaglia M, Scafati J, Cuchiaro N, Rebak J, Pineda S, Calvo M, Picco E, Yanzi J, Maid P, Guaglianone D, Morbiducci J, Porta S, Herscovich N, Velasco Zamora J, Kisluk B, Castaños Menescardi M, Gallo R, Martire M, Maldini C, Goizueta C, de la Vega Fernandez S, Aeschlimann C, Subils G, Rath E, Piette Y, Devinck M, Maeyaert B, Machado Ribeiro F, Euzebio Ribeiro S, Pinheiro M, Ibáñez S, Chassin Trubert A, Dong L, Cajas L, Barešić M, Anić B, Čulo M, Pavelić T, Stranski K, Karanovic B, Vencovsky J, Píchová M, Filkova M, Hamoud H, Vassilopoulos D, Guzman Melgar G, So H, Király M, Vojdanian M, Balbir Gurman A, Abutiban F, Zepa J, Bulina I, Bukauskiene L, Zazueta Montiel B, Castillo Ortiz A, Zamora Tehozol E, Vega Morales D, Cervántes Rosete D, Martín Nares E, Rodriguez Reyna T, Rull Gabayet M, Alpízar Rodríguez D, Irazoque F, Jimenez X, Geurts van Bon L, Zijlstra T, Hoekstra M, Al Adhoubi N, Salim B, Giraldo E, Salinas A, Ugarte Gil M, Nowakowski J, Conway R, Flood R, McCarthy G, Felea I, Filipescu I, Rednic S, Groseanu L, Tamas M, Mlynarikova V, Skamlova M, Zlnay M, Mičeková D, Capova L, Macejova Z, Šteňová E, Raffayova H, Belakova G, Strakova E, Senčarová M, Žlnayová S, Sabová A, Spisakova D, Oetterová M, Lukacova O, Bakosova M, Hocevar A, de la Torre Rubio N, Alegre Sancho J, Corteguera Coro M, Cobeta Garcia J, Torres Martin M, Campos J, Gomez Puerta J, Yardımcı G, Akar S, Icacan O, ÇELİK S, Vasylets V, Yeoh S, Vandevelde C, Dunt S, Leeder J, Macphie E, Salerno R, Graver C, Williams K, O'Reilly S, Devine K, Tyler J, Warner E, Pilcher J, Patel S, Nikiphorou E, Chadwick L, Jones C, Harrison B, Thornton L, O'Kane D, Fusi L, Low A, Horton S, Jatwani S, Baig S, Bajwa H, Berglund V, Dahle A, Dorman W, Hargrove J, Hilton M, Lebedoff N, Leonard S, Morgan J, Pfeifer E, Skemp A, Wilson J, Wolff A, Cepeda E, Todd D, Hare D, Calabrese C, Adams C, Khosroshahi A, Kilian A, White D, Winter M, Fields T, Siegel C, Daver N, Harvey M, Kramer N, Lamore C, Hogarty S, Yeter K, Siddique F, Ban B, Tanner T, Ruderman E, Davis W, Quinet R, Scopelitis E, Toribio K, Webb Detiege T, Zakem J, Abbass K, Kepecs G, Miranda L, Guma M, Haikal A, Mody S, Mueller D, Jayatilleke A, Zell J, Bays A, Dao K, Ezzati F, Parks D, Karp D, Quiceno G. Association Between Tumor Necrosis Factor Inhibitors and the Risk of Hospitalization or Death Among Patients With Immune-Mediated Inflammatory Disease and COVID-19. JAMA Network Open 2021, 4: e2129639. PMID: 34661663, PMCID: PMC8524310, DOI: 10.1001/jamanetworkopen.2021.29639.Peer-Reviewed Original ResearchConceptsTNF inhibitor monotherapyCOVID-19-associated hospitalizationTumor necrosis factor inhibitorsNecrosis factor inhibitorsInhibitor monotherapyInflammatory bowel diseaseTNF inhibitorsCOVID-19 outcomesPooled analysisMethotrexate monotherapyImmunomodulatory treatmentMethotrexate therapyClinical characteristicsCohort studyBowel diseaseFactor inhibitorsInflammatory diseasesMAIN OUTCOMEAdverse COVID-19 outcomesCOVID-19Multivariable logistic regression modelMultilevel multivariable logistic regression modelsJAK inhibitor monotherapyKinase inhibitor monotherapyRisk of hospitalizationAssociations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registry
Sparks J, Wallace Z, Seet A, Gianfrancesco M, Izadi Z, Hyrich K, Strangfeld A, Gossec L, Carmona L, Mateus E, Lawson-Tovey S, Trupin L, Rush S, Katz P, Schmajuk G, Jacobsohn L, Wise L, Gilbert E, Duarte-García A, Valenzuela-Almada M, Pons-Estel G, Isnardi C, Berbotto G, Hsu T, D’Silva K, Patel N, Kearsley-Fleet L, Schäfer M, Ribeiro S, Al Emadi S, Tidblad L, Scirè C, Raffeiner B, Thomas T, Flipo R, Avouac J, Seror R, Bernardes M, Cunha M, Hasseli R, Schulze-Koops H, Müller-Ladner U, Specker C, de Souza V, da Mota L, Gomides A, Dieudé P, Nikiphorou E, Kronzer V, Singh N, Ugarte-Gil M, Wallace B, Akpabio A, Thomas R, Bhana S, Costello W, Grainger R, Hausmann J, Liew J, Sirotich E, Sufka P, Robinson P, Machado P, Yazdany J, Dahou B, Quintana R, Gómez G, Roberts K, Baez R, Coello V, Salinas M, Maldonado F, Reyes A, Alle G, Tanten R, Ficco H, Nieto R, Gobbi C, Tissera Y, Pisoni C, Paula A, Albiero J, Schmid M, Cosatti M, Gamba M, Leandro C, Cusa M, German N, Bellomio V, Takashima L, Pera M, Cogo K, Elkin M, Medina M, Savio V, Tessel I, Alamino R, Werner M, Ornella S, Casalla L, de la Vega M, Severina M, García M, Lucero L, Romeo C, Moyano S, Barbich T, Bertoli A, Baños A, Petruzzelli S, Matellan C, Conti S, Lazaro M, Gil G, Risueño F, Quaglia M, Scafati J, Cuchiaro N, Rebak J, Pineda S, Calvo M, Picco E, Yanzi J, Maid P, Guaglianone D, Morbiducci J, Porta S, Herscovich N, Zamora J, Kisluk B, Menescardi M, Gallo R, Martire M, Maldini C, Goizueta C, de Fernandez S, Argentina C, Subils G, Rath E, Piette Y, Devinck M, Maeyaert B, Ribeiro F, Ribeiro S, Pinheiro M, Ibáñez S, Chassin-Trubert A, Dong L, Cajas L, Barešić M, Anić B, Čulo M, Pavelić T, Stranski K, Karanovic B, Vencovsky J, Píchová M, Filkova M, Hamoud H, Vassilopoulos D, Melgar G, So H, Király M, Vojdanian, Balbir-Gurman A, Abutiban F, Zepa J, Bulina I, Bukauskiene L, Zazueta-Montiel B, Castillo-Ortiz A, Zamora-Tehozol E, Vega-Morales D, Rosete D, Martín-Nares E, Rodriguez-Reyna T, Gabayet M, Alpízar-Rodríguez D, Irazoque F, Jimenez X, Bon L, Zijlstra T, Hoekstra M, Al-Adhoubi N, Salim B, Giraldo E, Salinas A, Ugarte-Gil M, Nowakowski J, Al-Emadi S, Conway R, Flood R, McCarthy G, Felea I, Filipescu I, Rednic S, Groseanu L, Tamas M, Mlynarikova V, Skamlova M, Zlnay M, Mičeková D, Capova L, Macejova Z, Šteňová E, Raffayova H, Belakova G, Strakova E, Senčarová M, Sabová A, Spisakova D, Oetterová M, Lukacova O, Bakosova M, Hocevar A, de la Torre-Rubio N, Sancho J, Coro M, Garcia J, Martin M, Campos J, Puerta J, Yardımcı G, Akar S, Icacan O, ÇELİK S, Vasylets V, Yeoh S, Vandevelde C, Dunt S, Leeder J, Macphie E, Salerno R, Graver C, Williams K, O'Reilly S, Devine K, Tyler J, Warner E, Pilcher J, Patel S, Nikiphorou E, Chadwick L, Jones C, Harrison B, Thornton L, O'Kane D, Fusi L, Low A, Horton S, Jatwani S, Baig S, Bajwa H, Berglund V, Dahle A, Dorman W, Hargrove J, Hilton M, Lebedoff N, Leonard S, Morgan J, Pfeifer E, Skemp A, Wilson J, Wolff A, Cepeda E, Todd D, Hare D, Calabrese C, Adams C, Khosroshahi A, Kilian A, White D, Winter M, Fields T, Siegel C, Daver N, Harvey M, Kramer N, Lamore C, Hogarty S, Yeter K, Wise L, Siddique F, Ban B, Tanner T, Ruderman E, Davis W, Quinet R, Scopelitis E, Toribio K, Webb-Detiege T, Zakem J, Abbass K, Kepecs G, Miranda L, Guma M, Haikal A, Mody S, Mueller D, Jayatilleke A, Zell J, Bays A, Dao K, Fatemeh E, Parks D, Karp D, Quiceno G. Associations of baseline use of biologic or targeted synthetic DMARDs with COVID-19 severity in rheumatoid arthritis: Results from the COVID-19 Global Rheumatology Alliance physician registry. Annals Of The Rheumatic Diseases 2021, 80: 1137-1146. PMID: 34049860, PMCID: PMC8172266, DOI: 10.1136/annrheumdis-2021-220418.Peer-Reviewed Original ResearchConceptsDisease-modifying antirheumatic drugsCOVID-19 severitySynthetic disease-modifying antirheumatic drugsWorse COVID-19 severityRheumatoid arthritisBaseline useCOVID-19 severity outcomeTumor necrosis factor inhibitorsInterleukin-6 inhibitorsNecrosis factor inhibitorsPotential baseline confoundersCOVID-19 outcomesPhysician registryCOVID-19IL-6iAntirheumatic drugsClinical onsetBaseline confoundersFactor inhibitorsOrdinal logistic regressionDrug classesRituximabAbataceptTNFiHospitalisationOP0286 CHARACTERISTICS ASSOCIATED WITH SEVERE COVID-19 OUTCOMES IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): RESULTS FROM THE COVID-19 GLOBAL RHEUMATOLOGY ALLIANCE (COVID-19 GRA)
Ugarte-Gil M, Alarcon G, Seet A, Izadi Z, Reategui Sokolova C, Clarke A, Wise L, Pons-Estel G, Santos M, Bernatsky S, Mathias L, Lim N, Sparks J, Wallace Z, Hyrich K, Strangfeld A, Gossec L, Carmona L, Mateus E, Lawson-Tovey S, Trupin L, Rush S, Schmajuk G, Katz P, Jacobsohn L, Al Emadi S, Gilbert E, Duarte-Garcia A, Valenzuela-Almada M, Hsu T, D’silva K, Serling-Boyd N, Dieudé P, Nikiphorou E, Kronzer V, Singh N, Wallace B, Akpabio A, Thomas R, Bhana S, Costello W, Grainger R, Hausmann J, Liew J, Sirotich E, Sufka P, Robinson P, Machado P, Gianfrancesco M, Yazdany J. OP0286 CHARACTERISTICS ASSOCIATED WITH SEVERE COVID-19 OUTCOMES IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): RESULTS FROM THE COVID-19 GLOBAL RHEUMATOLOGY ALLIANCE (COVID-19 GRA). Annals Of The Rheumatic Diseases 2021, 80: 173.2-175. DOI: 10.1136/annrheumdis-2021-eular.2984.Peer-Reviewed Original ResearchSystemic lupus erythematosusChronic renal diseaseModerate/high disease activityNon-invasive ventilationSevere COVID-19 outcomesBristol-Myers SquibbDisease activityGrant/research supportRenal diseaseCOVID-19 outcomesCOVID-19 diagnosisDrug monotherapyImmunomodulatory therapyGlobal Rheumatology AllianceMembrane oxygenationCOVID-19 Global Rheumatology AllianceNational Institute for Health ResearchMale sexModerate to high daily dosesSLE adult patientsBristol-MyersSystemic lupus erythematosus patientsSystemic lupus erythematosus therapyCardiovascular diseaseOdds of poor outcomeOP0006 ASSOCIATIONS OF BASELINE USE OF BIOLOGIC OR TARGETED SYNTHETIC DMARDS WITH COVID-19 SEVERITY IN RHEUMATOID ARTHRITIS: RESULTS FROM THE COVID-19 GLOBAL RHEUMATOLOGY ALLIANCE
Sparks J, Wallace Z, Seet A, Gianfrancesco M, Izadi Z, Hyrich K, Strangfeld A, Gossec L, Carmona L, Mateus E, Lawson-Tovey S, Trupin L, Rush S, Schmajuk G, Katz P, Jacobsohn L, Al Emadi S, Wise L, Gilbert E, Duarte-Garcia A, Valenzuela-Almada M, Hsu T, D’silva K, Serling-Boyd N, Dieudé P, Nikiphorou E, Kronzer V, Singh N, Ugarte-Gil M, Wallace B, Akpabio A, Thomas R, Bhana S, Costello W, Grainger R, Hausmann J, Liew J, Sirotich E, Sufka P, Robinson P, Machado P, Yazdany J. OP0006 ASSOCIATIONS OF BASELINE USE OF BIOLOGIC OR TARGETED SYNTHETIC DMARDS WITH COVID-19 SEVERITY IN RHEUMATOID ARTHRITIS: RESULTS FROM THE COVID-19 GLOBAL RHEUMATOLOGY ALLIANCE. Annals Of The Rheumatic Diseases 2021, 80: 2.1-4. DOI: 10.1136/annrheumdis-2021-eular.1632.Peer-Reviewed Original ResearchTumor necrosis factor inhibitorsTNFi usersInterleukin-6 inhibitorsJanus kinase inhibitorsRituximab usersCOVID-19 severityBristol-Myers SquibbRA disease activityGrant/research supportAssociated with greater oddsRheumatoid arthritisCOVID-19 outcomesPoor COVID-19 outcomesGlobal Rheumatology AllianceSynthetic DMARDsCOVID-19 Global Rheumatology AllianceDMARD useDisease activityBristol-MyersJanus kinase inhibitor usePropensity scoreTumor necrosis factor inhibitor useRheumatic diseasesBaseline useOptimal timing of vaccinationAssociation of Race and Ethnicity With COVID‐19 Outcomes in Rheumatic Disease: Data From the COVID‐19 Global Rheumatology Alliance Physician Registry
Gianfrancesco M, Leykina L, Izadi Z, Taylor T, Sparks J, Harrison C, Trupin L, Rush S, Schmajuk G, Katz P, Jacobsohn L, Hsu T, D’Silva K, Serling‐Boyd N, Wallwork R, Todd D, Bhana S, Costello W, Grainger R, Hausmann J, Liew J, Sirotich E, Sufka P, Wallace Z, Machado P, Robinson P, Yazdany J, Alliance T. Association of Race and Ethnicity With COVID‐19 Outcomes in Rheumatic Disease: Data From the COVID‐19 Global Rheumatology Alliance Physician Registry. Arthritis & Rheumatology 2021, 73: 374-380. PMID: 33146001, PMCID: PMC8467766, DOI: 10.1002/art.41567.Peer-Reviewed Original ResearchConceptsRheumatic diseasesGeneral US populationRace/ethnicityVentilatory supportLatinx patientsOdds ratioUS populationCOVID-19Rheumatic disease activityRheumatic disease diagnosisOdds of hospitalizationAfrican American patientsAssociation of raceCOVID-19 outcomesPhysician registryCoronavirus disease 2019COVID-19 hospitalizationMultivariable regression modelsSignificant health disparitiesNeeds of patientsInequitable health outcomesDisease activityHospitalized patientsMedication useWhite patients
2020
Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry
Gianfrancesco M, Hyrich K, Al-Adely S, Carmona L, Danila M, Gossec L, Izadi Z, Jacobsohn L, Katz P, Lawson-Tovey S, Mateus E, Rush S, Schmajuk G, Simard J, Strangfeld A, Trupin L, Wysham K, Bhana S, Costello W, Grainger R, Hausmann J, Liew J, Sirotich E, Sufka P, Wallace Z, Yazdany J, Machado P, Robinson P. Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry. Annals Of The Rheumatic Diseases 2020, 79: 859-866. PMID: 32471903, PMCID: PMC7299648, DOI: 10.1136/annrheumdis-2020-217871.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnti-Inflammatory Agents, Non-SteroidalAntimalarialsAntirheumatic AgentsArthritis, PsoriaticArthritis, RheumatoidBetacoronavirusBiological ProductsCoronavirus InfectionsCOVID-19FemaleGlucocorticoidsHospitalizationHumansJanus Kinase InhibitorsLupus Erythematosus, SystemicMaleMiddle AgedMultivariate AnalysisPandemicsPneumonia, ViralPrednisoneProtective FactorsRegistriesRheumatic DiseasesRisk FactorsSARS-CoV-2Severity of Illness IndexSpondylarthropathiesTumor Necrosis Factor InhibitorsVasculitisYoung AdultConceptsDisease-modifying antirheumatic drugsRheumatic diseasesHospitalisation statusHigher oddsNon-steroidal anti-inflammatory drug useConventional disease-modifying antirheumatic drugsAnti-inflammatory drug useOdds of hospitalisationRheumatic disease diagnosisRheumatic disease medicationsMultivariable-adjusted modelsMultivariable logistic regressionJanus kinase inhibitorCOVID-19 outcomesCOVID-19Prednisone doseAntirheumatic drugsGlucocorticoid exposureInhibitor useAntimalarial useClinical factorsCase seriesSmoking statusReduced oddsDecreased odds