2018
Structural correlates of cognitive impairment in normal pressure hydrocephalus
Peterson KA, Mole TB, Keong NCH, DeVito EE, Savulich G, Pickard JD, Sahakian BJ. Structural correlates of cognitive impairment in normal pressure hydrocephalus. Acta Neurologica Scandinavica 2018, 139: 305-312. PMID: 30428124, PMCID: PMC6492129, DOI: 10.1111/ane.13052.Peer-Reviewed Original ResearchConceptsNormal pressure hydrocephalusNPH patientsNeuropsychiatric symptomsPressure hydrocephalusNeuropsychiatric measuresNeuropsychological testsStructure volumesStriatal volume lossDeep gray matter structuresMeasures of apathySubcortical deep gray matter structuresT1-weighted magnetic resonanceGray matter structuresNAcc volumeSmaller caudateNeuropsychiatric changesHealthy controlsPathological basisNPH groupCaudate nucleusNucleus accumbensCaudate volumePatientsSubcortical regionsCognitive impairment
2017
Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus
Keong NC, Pena A, Price SJ, Czosnyka M, Czosnyka Z, DeVito EE, Housden CR, Sahakian BJ, Pickard JD. Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus. PLOS ONE 2017, 12: e0181624. PMID: 28817574, PMCID: PMC5560677, DOI: 10.1371/journal.pone.0181624.Peer-Reviewed Original ResearchConceptsNormal pressure hydrocephalusWhite matter injuryDiffusion tensor imagingPressure hydrocephalusInternal capsulePosterior limbDTI measuresPatterns of injuryDifferent white matter tractsNon-invasive biomarkersWhite matter tractsInferior longitudinal fasciculusClinical outcomesInjury patternsNPH patientsEarly diagnosisLongitudinal fasciculusAxial diffusivityTensor imagingInjuryHydrocephalusPatientsImaging profileIndividual tractsTract
2015
Apathy, ventriculomegaly and neurocognitive improvement following shunt surgery in normal pressure hydrocephalus
Peterson KA, Housden CR, Killikelly C, DeVito EE, Keong NC, Savulich G, Czosnyka Z, Pickard JD, Sahakian BJ. Apathy, ventriculomegaly and neurocognitive improvement following shunt surgery in normal pressure hydrocephalus. British Journal Of Neurosurgery 2015, 30: 38-42. PMID: 25968325, DOI: 10.3109/02688697.2015.1029429.Peer-Reviewed Original ResearchConceptsNormal pressure hydrocephalusMini-Mental State ExaminationApathy Evaluation ScaleGeriatric Depression ScaleShunt surgeryApathetic symptomsPressure hydrocephalusBicaudate ratioSubcortical atrophyCaudate atrophyFunctional outcomeGDS scoresNeurocognitive improvementDepression ScaleCognitive recoveryLevel of apathyState ExaminationVentriculomegalySurgerySymptomsCognitive outcomesHydrocephalusAtrophyEvaluation ScaleGoal-directed behavior
2007
Caudate structural abnormalities in idiopathic normal pressure hydrocephalus
DeVito E, Salmond C, Owler B, Sahakian B, Pickard J. Caudate structural abnormalities in idiopathic normal pressure hydrocephalus. Acta Neurologica Scandinavica 2007, 116: 328-332. PMID: 17922726, DOI: 10.1111/j.1600-0404.2007.00906.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAtrophyBasal Ganglia DiseasesCaudate NucleusCerebrospinal Fluid PressureCorpus CallosumDisease ProgressionFemaleHumansHydrocephalus, Normal PressureImage Processing, Computer-AssistedIntracranial HypertensionLateral VentriclesMagnetic Resonance ImagingMaleMiddle AgedPredictive Value of TestsConceptsNormal pressure hydrocephalusPressure hydrocephalusIdiopathic normal pressure hydrocephalusManual volumetric analysisVoxel-based morphometric analysisCaudate nucleus volumeStructural volumetric changesINPH patientsReversible dementiaINPH groupHealthy controlsCaudate nucleusStructural abnormalitiesCognitive deficitsVolumetric analysisNucleus volumeHydrocephalusRegion of interestROI measurementsINPHMorphometric analysisAffective changes
2005
The neuropsychology of normal pressure hydrocephalus (NPH)
Devito EE, Pickard JD, Salmond CH, Iddon JL, Loveday C, Sahakian BJ. The neuropsychology of normal pressure hydrocephalus (NPH). British Journal Of Neurosurgery 2005, 19: 217-224. PMID: 16455521, DOI: 10.1080/02688690500201838.Peer-Reviewed Original Research