Eduardo Martin-Lopez
Associate Research Scientist in NeurosurgeryCards
About
Research
Publications
2024
Dissecting reactive astrocyte responses: lineage tracing and morphology-based clustering
Delgado-García L, Ojalvo-Sanz A, Nakamura T, Martín-López E, Porcionatto M, Lopez-Mascaraque L. Dissecting reactive astrocyte responses: lineage tracing and morphology-based clustering. Biological Research 2024, 57: 54. PMID: 39143594, PMCID: PMC11323641, DOI: 10.1186/s40659-024-00532-y.Peer-Reviewed Original ResearchInflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2
Martin-Lopez E, Brennan B, Mao T, Spence N, Meller S, Han K, Yahiaoui N, Wang C, Iwasaki A, Greer C. Inflammatory Response and Defects on Myelin Integrity in the Olfactory System of K18hACE2 Mice Infected with SARS-CoV-2. ENeuro 2024, 11: eneuro.0106-24.2024. PMID: 38834299, PMCID: PMC11185043, DOI: 10.1523/eneuro.0106-24.2024.Peer-Reviewed Original ResearchOlfactory bulbOlfactory epitheliumPiriform cortexOlfactory tractOlfactory systemSARS-CoV-2Projection neuronsMyelination defectsOlfactory sensory neuronsLateral olfactory tractLoss of olfactionRespiratory epithelial cellsLamina propria macrophagesSARS-CoV-2 infectionInfected SCDays of infectionIntegrity of myelinOlfactory dysfunctionInfected microgliaSensitive to infectionOlfactory deficitsSensory neuronsSustentacular cellsNasal cavityNeuronal conduction
2023
Microglia Maintain Homeostatic Conditions in the Developing Rostral Migratory Stream
Meller S, Hernandez L, Martin-Lopez E, Kloos Z, Liberia T, Greer C. Microglia Maintain Homeostatic Conditions in the Developing Rostral Migratory Stream. ENeuro 2023, 10: eneuro.0197-22.2023. PMID: 36697258, PMCID: PMC9910579, DOI: 10.1523/eneuro.0197-22.2023.Peer-Reviewed Original Researchα-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.Peer-Reviewed Original ResearchConceptsΑ-syn tg miceΑ-Syn pathologyOlfactory bulb neurogenesisProjection neuronsParkinson's diseaseOlfactory dysfunctionMutant α-synucleinOlfactory deficitsOlfactory pathwaySyn pathologyBehavioral deficitsMouse modelΑ-synucleinOB granule cellsΑ-synuclein pathologyOlfactory systemMonths of ageReduced neurogenesisFunctional deficitsPeriglomerular cellsMotor progressionPathologic changesMultiple symptomsSynaptic terminalsGranule cells
2019
Embryonic and postnatal development of mouse olfactory tubercle
Martin-Lopez E, Xu C, Liberia T, Meller SJ, Greer CA. Embryonic and postnatal development of mouse olfactory tubercle. Molecular And Cellular Neuroscience 2019, 98: 82-96. PMID: 31200100, DOI: 10.1016/j.mcn.2019.06.002.Peer-Reviewed Original ResearchConceptsOlfactory tubercleVentral striatumOlfactory bulb projection neuronsPrimary afferent inputTyrosine hydroxylase expressionLateral ganglionic eminenceDopamine reward systemCNPase stainingVentral medial regionDopaminergic innervationProjection neuronsStriatal neuronsVentral tegmentumAfferent inputDopaminergic inputLaminar distributionMedial gradientHydroxylase expressionNucleus accumbensGanglionic eminencePostnatal developmentE11-E15OT cellsVentral lateral ganglionic eminencePostnatal stages
2018
Development of piriform cortex interhemispheric connections via the anterior commissure: progressive and regressive strategies
Martin-Lopez E, Meller SJ, Greer CA. Development of piriform cortex interhemispheric connections via the anterior commissure: progressive and regressive strategies. Brain Structure And Function 2018, 223: 4067-4085. PMID: 30141078, PMCID: PMC6252112, DOI: 10.1007/s00429-018-1741-y.Peer-Reviewed Original ResearchConceptsAnterior commissurePostnatal developmentPostnatal day 22Inter-hemispheric connectionsChondroitin sulfate proteoglycanPiriform cortexContralateral innervationGlial cellsOlfactory areasBed nucleusInterhemispheric connectionsStria terminalisDay 22Axonal tractsAxon growthNew subtypeAxon outgrowthCalretininCommissureSulfate proteoglycanAxonsPhenotypeInnervationIpsiImmunohistochemistry
2017
The Laminar Organization of Piriform Cortex Follows a Selective Developmental and Migratory Program Established by Cell Lineage
Martin-Lopez E, Ishiguro K, Greer CA. The Laminar Organization of Piriform Cortex Follows a Selective Developmental and Migratory Program Established by Cell Lineage. Cerebral Cortex 2017, 29: 1-16. PMID: 29136113, PMCID: PMC7199997, DOI: 10.1093/cercor/bhx291.Peer-Reviewed Original ResearchConceptsLaminar specificityLaminar organizationNeurogenesis/gliogenesisPrimary afferent inputNeurogenic patternPiriform cortexAfferent inputNeurogenic gradientOlfactory bulbLayers IIGlial organizationNeuronal migrationPC progenitorsLaminar developmentCortexFunctional organizationClonal analysisCell lineagesLikely roleEarly developmentPaleocortexAnteriorNeurogenesisSpecificityGliogenesis
2015
Decoding astrocyte heterogeneity: New tools for clonal analysis
Bribián A, Figueres-Oñate M, Martín-López E, López-Mascaraque L. Decoding astrocyte heterogeneity: New tools for clonal analysis. Neuroscience 2015, 323: 10-19. PMID: 25917835, DOI: 10.1016/j.neuroscience.2015.04.036.Peer-Reviewed Original ResearchConceptsEmbryonic developmentAstrocyte lineagePowerful genetic toolsBiology of astrocytesGenetic toolsCell heterogeneityLineagesOntogenetic originAstrocyte heterogeneityClonal analysisPhysiological featuresSpecific labelingAstrocyte progenitorsClonesAdult brainCell clonesAstrocyte clonesFinal fateExciting areaNew toolProgenyBiologyProgenitorsChanges in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea.
Maass JC, Gu R, Basch ML, Waldhaus J, Lopez EM, Xia A, Oghalai JS, Heller S, Groves AK. Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea. Frontiers In Cellular Neuroscience 2015, 9: 110. PMID: 25873862, PMCID: PMC4379755, DOI: 10.3389/fncel.2015.00110.Peer-Reviewed Original Research
2013
Clonal Astrocytic Response to Cortical Injury
Martín-López E, García-Marques J, Núñez-Llaves R, López-Mascaraque L. Clonal Astrocytic Response to Cortical Injury. PLOS ONE 2013, 8: e74039. PMID: 24040158, PMCID: PMC3769363, DOI: 10.1371/journal.pone.0074039.Peer-Reviewed Original ResearchConceptsDays post injuryHigher proliferative responsesCentral nervous systemCortical injuryStrong morphological alterationsAstrocytic responsePost injuryBrain injuryGlial functionGlial cellsProliferative responseImmunohistochemical analysisNervous systemAstrocyte heterogeneitySame cloneInjuryMechanical injuryAstrocytesMorphological alterationsClonal responseHeterogeneous populationDistinct clonesCell lineagesMorphological changesMultifaceted role
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