2024
Associations between parental psychopathology and youth functional emotion regulation brain networks
Karl V, Beck D, Eilertsen E, Morawetz C, Wiker T, Aksnes E, Norbom L, Ferschmann L, MacSweeney N, Voldsbekk I, Andreassen O, Westlye L, Gee D, Engen H, Tamnes C. Associations between parental psychopathology and youth functional emotion regulation brain networks. Developmental Cognitive Neuroscience 2024, 70: 101476. PMID: 39541797, DOI: 10.1016/j.dcn.2024.101476.Peer-Reviewed Original ResearchParental psychopathologyYouth psychopathologyEmotion regulationAssociated with children's emotion regulationResting-state functional magnetic resonance imaging dataAdolescent Brain Cognitive Development StudyIntergenerational transmission of psychopathologyAssociated with lower connectivityFunctional magnetic resonance imaging dataTransmission of psychopathologyChildren's emotion regulationCognitive Development StudyMagnetic resonance imaging dataParental mental healthPFC networksPsychopathologyBrain networksParental internalizingMediation analysisCognitive aspectsMental healthConnectivity patternsIntergenerational transmissionNetwork connectivityYouth
2013
Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation
Gee DG, Gabard-Durnam LJ, Flannery J, Goff B, Humphreys KL, Telzer EH, Hare TA, Bookheimer SY, Tottenham N. Early developmental emergence of human amygdala–prefrontal connectivity after maternal deprivation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 15638-15643. PMID: 24019460, PMCID: PMC3785723, DOI: 10.1073/pnas.1307893110.Peer-Reviewed Original ResearchConceptsMaternal deprivationAmygdala-mPFC connectivityEarly adversityEarly maternal deprivationAmygdala-prefrontal connectivityMature connectivityRodent modelsReduced anxietyAdolescent phenotypeHormone cortisolEarly developmental emergenceStress-induced modificationsDeprivationComparison childrenConnectivity patternsChildrenDevelopmental emergenceAnxietyPhenotypeInstitutionalized youthAmygdalaAdversityCortisolOntogenetic adaptation