2020
Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype
Contreras KM, Caillaud M, Neddenriep B, Bagdas D, Roberts JL, Ulker E, White AB, Aboulhosn R, Toma W, Khalefa T, Adel A, Mann JA, Damaj MI. Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype. Behavioural Brain Research 2020, 399: 113009. PMID: 33181181, PMCID: PMC8961431, DOI: 10.1016/j.bbr.2020.113009.Peer-Reviewed Original ResearchConceptsNeuropathic pain modelChronic constriction injuryMechanical withdrawal thresholdPain modelStrains of miceWithdrawal thresholdDBA/2J miceVoluntary wheelChronic neuropathic pain modelPaclitaxel-treated miceVehicle-treated miceUnilateral intraplantar injectionLower mechanical thresholdsChronic pain reportQuality of lifeChemotherapy agent paclitaxelImpact of sexDifferent mouse strainsCCI miceCCI surgeryConstriction injuryIntraplantar injectionSham surgeryMale C57BL/6JNovel analgesics
2017
Nicotine prevents and reverses paclitaxel-induced mechanical allodynia in a mouse model of CIPN
Kyte S, Toma W, Bagdas D, Meade J, Schurman L, Lichtman A, Chen Z, Del Fabbro E, Fang X, Bigbee J, Damaj M, Gewirtz D. Nicotine prevents and reverses paclitaxel-induced mechanical allodynia in a mouse model of CIPN. Journal Of Pharmacology And Experimental Therapeutics 2017, 364: jpet.117.243972. PMID: 29042416, PMCID: PMC5738719, DOI: 10.1124/jpet.117.243972.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyPaclitaxel-induced mechanical allodyniaMechanical allodyniaPeripheral neuropathyMouse modelTreatment of CIPNLewis lung carcinoma tumor growthIntraepidermal nerve fiber lossPaclitaxel-induced peripheral neuropathyH460 non-small cell lung cancer cellsNon-small cell lung cancer cellsLung tumor cell proliferationNerve fiber dysfunctionNicotinic acetylcholine receptor subtypesCell lung cancer cellsChronic nicotine administrationNerve fiber lossChronic nicotine treatmentMale C57BL/6J miceAcetylcholine receptor subtypesLung cancer cellsProliferation of A549Receptor-mediated pathwayTumor cell proliferationCIPN treatmentEffects of paclitaxel on the development of neuropathy and affective behaviors in the mouse
Toma W, Kyte S, Bagdas D, Alkhlaif Y, Alsharari S, Lichtman A, Chen Z, Del Fabbro E, Bigbee J, Gewirtz D, Damaj M. Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse. Neuropharmacology 2017, 117: 305-315. PMID: 28237807, PMCID: PMC5489229, DOI: 10.1016/j.neuropharm.2017.02.020.Peer-Reviewed Original ResearchMeSH KeywordsAnhedoniaAnimalsAntineoplastic Agents, PhytogenicAnxietyBehavior, AnimalCarboplatinDepressionEpidermisHyperalgesiaMaleMice, Inbred C57BLMotor ActivityNociceptive PainPaclitaxelRandom AllocationConceptsCancer chemotherapeutic drugsCancer patientsPreclinical modelsSide effectsAffective symptomsMajor dose-limiting side effectDose-limiting side effectChemotherapeutic drugsLight/dark box testNerve fiber dysfunctionPaclitaxel-treated miceProgression-free survivalSucrose preference testDepression-like behaviorOvarian cancer patientsSevere side effectsAnxiety-like behaviorPotential therapeutic interventionsEffect of paclitaxelAnhedonia-like stateDark box testCold allodyniaNeuropathic painNegative affective symptomsNociceptive effects