2017
Effects of Adrenomedullin and Glucagon-like Peptide on Distal Flap Necrosis and Vascularity: The Role of Receptor Systems and Nitric Oxide.
Cam B, Bagdas D, Ozyigit M, Sagdilek E, Buyukcoskun N, Ozluk K. Effects of Adrenomedullin and Glucagon-like Peptide on Distal Flap Necrosis and Vascularity: The Role of Receptor Systems and Nitric Oxide. WOUNDS A Compendium Of Clinical Research And Practice 2017, 29: 163-167. PMID: 28355142.Peer-Reviewed Original ResearchMeSH KeywordsAdrenomedullinAnimalsAntioxidantsCalcitonin Gene-Related PeptideDisease Models, AnimalEpigastric ArteriesFemaleGlucagon-Like Peptide ReceptorsGlucagon-Like PeptidesGraft SurvivalImmunohistochemistryNecrosisNitric OxideRatsRats, WistarReceptors, Calcitonin Gene-Related PeptideSurgical FlapsWound HealingWounds and InjuriesConceptsGlucagon-like peptide-1Superficial inferior epigastric arteryEffects of adrenomedullinFlap healingNitric oxideFlap necrosisReceptor antagonistNecrosis areaGLP-1 receptor antagonistCalcitonin gene-related peptide receptorAdult female Wistar ratsGene-related peptide receptorBeneficial effectsADM receptor antagonistAdministration of adrenomedullinPostoperative day 7Inferior epigastric arteryGLP-1 receptorDistal flap necrosisFemale Wistar ratsGlucagon-like peptideMajor complicationsCGRP receptorsEpigastric arteryWistar rats
2015
In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile
Bagdas D, Etoz B, Gul Z, Ziyanok S, Inan S, Turacozen O, Gul N, Topal A, Cinkilic N, Tas S, Ozyigit M, Gurun M. In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile. Food And Chemical Toxicology 2015, 81: 54-61. PMID: 25846499, DOI: 10.1016/j.fct.2015.04.001.Peer-Reviewed Original ResearchConceptsSide effectsOxidative stressStreptozotocin-induced diabetic ratsChronic antioxidant treatmentEndogenous antioxidant defense systemNitric oxide levelsWound healingBlood glucose levelsSystemic antioxidant therapyDays of treatmentPossible side effectsDiabetic wound repairLipid peroxidation levelsChlorogenic acidAcid therapyDiabetic ratsHistopathological examinationPossible pro-oxidative effectsPro-oxidative effectsAntioxidant intakePivotal organAntioxidant therapyDiabetic conditionsAntioxidant balanceGlucose levels
2014
Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing
Bagdas D, Gul N, Topal A, Tas S, Ozyigit M, Cinkilic N, Gul Z, Etoz B, Ziyanok S, Inan S, Turacozen O, Gurun M. Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing. Naunyn-Schmiedeberg's Archives Of Pharmacology 2014, 387: 1101-1116. PMID: 25129377, DOI: 10.1007/s00210-014-1034-9.Peer-Reviewed Original ResearchConceptsSide effectsWound healingHigh doseBone marrowEffects of CGAAnti-inflammatory effectsDietary chlorogenic acidNitric oxide levelsMatrix metalloproteinase-9Oxidative stress markersPossible side effectsDose-dependent mannerChlorogenic acidCGA supplementationPharmacologic overviewFree radical scavengerAcid therapyCGA treatmentLeukocyte infiltrationPivotal organImmunohistochemical examinationRat bone marrowMetalloproteinase-9Oxide levelsStress markers
2013
Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats
Bagdas D, Etoz B, Ozturkoglu S, Cinkilic N, Ozyigit M, Gul Z, Buyukcoskun N, Ozluk K, Gurun M. Effects of Systemic Chlorogenic Acid on Random-Pattern Dorsal Skin Flap Survival in Diabetic Rats. Biological And Pharmaceutical Bulletin 2013, 37: 361-370. PMID: 24389556, DOI: 10.1248/bpb.b13-00635.Peer-Reviewed Original ResearchConceptsSkin flap survivalFlap survivalDiabetic ratsNondiabetic ratsCapillary densityBlood perfusionVascular endothelial growth factor (VEGF) expressionPostoperative day 7Nitric oxide levelsMale Wistar ratsDorsal skin flapDorsal skin flap modelSkin flap modelGrowth factor expressionPotent antioxidant effectsChlorogenic acidRegional blood perfusionCGA treatmentWistar ratsSOD levelsOxide levelsSkin flapsNO levelsFlap tissueDay 7