2018
Monoacylglycerol lipase inhibitors reverse paclitaxel-induced nociceptive behavior and proinflammatory markers in a mouse model of chemotherapy-induced neuropathy
Curry Z, Wilkerson J, Bagdas D, Kyte S, Patel N, Donvito G, Mustafa M, Poklis J, Niphakis M, Hsu K, Cravatt B, Gewirtz D, Damaj M, Lichtman A. Monoacylglycerol lipase inhibitors reverse paclitaxel-induced nociceptive behavior and proinflammatory markers in a mouse model of chemotherapy-induced neuropathy. Journal Of Pharmacology And Experimental Therapeutics 2018, 366: jpet.117.245704. PMID: 29540562, PMCID: PMC6038031, DOI: 10.1124/jpet.117.245704.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsApoptosisBenzodioxolesBiomarkersCarbamatesCell Line, TumorCell ProliferationChemokine CCL2Disease Models, AnimalDose-Response Relationship, DrugEnzyme InhibitorsHumansHyperalgesiaInflammationMaleMiceMonoacylglycerol LipasesNociceptionP38 Mitogen-Activated Protein KinasesPaclitaxelPhosphoproteinsPiperidinesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2SuccinimidesConceptsAntinociceptive effectPaclitaxel-induced mechanical allodyniaPaclitaxel-induced neuropathic painH460 non-small cell lung cancer cellsNon-small cell lung cancer cellsMonoacylglycerol lipaseMonocyte chemoattractant protein-1Chemotherapy-induced neuropathyPaclitaxel-induced allodyniaPain side effectsPrimary hydrolytic enzymesCell lung cancer cellsSpinal dorsal hornDorsal root gangliaChemoattractant protein-1Novel pharmacologic strategiesPaclitaxel-treated animalsNumerous rodent modelsLung cancer cellsPlace preference paradigmMonoacylglycerol lipase inhibitorsIntrinsic rewarding effectsPhospho-p38 MAPKMechanical allodyniaNeuropathic pain
2015
Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice
Bagdas D, Muldoon P, AlSharari S, Carroll F, Negus S, Damaj M. Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice. Neuropharmacology 2015, 102: 236-243. PMID: 26639043, PMCID: PMC5574195, DOI: 10.1016/j.neuropharm.2015.11.024.Peer-Reviewed Original ResearchMeSH Keywords3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-IsomerAnalgesics, OpioidAnimalsAnti-Inflammatory Agents, Non-SteroidalAvoidance LearningBehavior, AnimalKetoprofenMaleMiceMice, Inbred ICRMorphinePiperidinesReceptors, Opioid, kappaReceptors, Opioid, muTetrahydroisoquinolinesVisceral PainConceptsMu-opioid receptor agonist morphinePlace aversionOpioid receptor agonist morphineReceptor agonist morphineMale ICR micePlace aversion (CPA) testPreclinical mouse modelsCandidate analgesicsNonsteroidal anti-inflammatory drug ketoprofenAgonist morphineOpioid agonistsICR miceIntraperitoneal administrationAnti-inflammatory drug ketoprofenPreclinical studiesMouse modelPharmacological modulationAnimal modelsMorphinePainReversal abilityAversion testAversive behaviorMiceBiological mechanisms