2020
Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype
Contreras KM, Caillaud M, Neddenriep B, Bagdas D, Roberts JL, Ulker E, White AB, Aboulhosn R, Toma W, Khalefa T, Adel A, Mann JA, Damaj MI. Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype. Behavioural Brain Research 2020, 399: 113009. PMID: 33181181, PMCID: PMC8961431, DOI: 10.1016/j.bbr.2020.113009.Peer-Reviewed Original ResearchConceptsNeuropathic pain modelChronic constriction injuryMechanical withdrawal thresholdPain modelStrains of miceWithdrawal thresholdDBA/2J miceVoluntary wheelChronic neuropathic pain modelPaclitaxel-treated miceVehicle-treated miceUnilateral intraplantar injectionLower mechanical thresholdsChronic pain reportQuality of lifeChemotherapy agent paclitaxelImpact of sexDifferent mouse strainsCCI miceCCI surgeryConstriction injuryIntraplantar injectionSham surgeryMale C57BL/6JNovel analgesics
2019
Molecular and behavioral mechanisms mediating paclitaxel‐induced changes in affect‐like behavior in mice
Meade J, Toma W, Alkhlaif Y, Bagdas D, Obeng S, Selley D, Damaj M. Molecular and behavioral mechanisms mediating paclitaxel‐induced changes in affect‐like behavior in mice. The FASEB Journal 2019, 33: 807.1-807.1. DOI: 10.1096/fasebj.2019.33.1_supplement.807.1.Peer-Reviewed Original ResearchKappa-opioid receptorsPaclitaxel-induced changesDepression-like behaviorInjection of vehicleNucleus accumbensSucrose preferenceRole of KORSelective KOR antagonist norbinaltorphimineDopamine D 2 receptorsKOR antagonist norbinaltorphimineTreatment-resistant depressionFemale C57BL/6J miceQuality of lifeFull-text articlesBaby boomer populationCancer survivorsAntagonist norbinaltorphimineC57BL/6J miceOpioid receptorsCancer ageKOR agonistsNeurochemical targetsTherapeutic interventionsPalatable foodProdynorphin mRNA