2022
Genotypic Differences in the Effects of Menthol on Nicotine Intake and Preference in Mice
Akinola LS, Rahman Y, Ondo O, Gonzales J, Bagdas D, Jackson A, Davidson-Wert N, Damaj MI. Genotypic Differences in the Effects of Menthol on Nicotine Intake and Preference in Mice. Frontiers In Neuroscience 2022, 16: 905330. PMID: 35769694, PMCID: PMC9234577, DOI: 10.3389/fnins.2022.905330.Peer-Reviewed Original ResearchOral nicotine consumptionEffect of mentholD2J miceMenthol effectsNicotine consumptionΑ7 nAChRsDifferential effectsTwo-bottle choiceTAAR1 geneOral aversionC57BL/6J miceNicotine rewardSystemic administrationNicotine intakeDBA/2J miceB6J micePharmacological responseNicotine addictionGenotype-specific mechanismsNicotine concentrationsMiceMouse strainsBasal preferenceGenetic factorsNicotine
2020
Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype
Contreras KM, Caillaud M, Neddenriep B, Bagdas D, Roberts JL, Ulker E, White AB, Aboulhosn R, Toma W, Khalefa T, Adel A, Mann JA, Damaj MI. Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype. Behavioural Brain Research 2020, 399: 113009. PMID: 33181181, PMCID: PMC8961431, DOI: 10.1016/j.bbr.2020.113009.Peer-Reviewed Original ResearchConceptsNeuropathic pain modelChronic constriction injuryMechanical withdrawal thresholdPain modelStrains of miceWithdrawal thresholdDBA/2J miceVoluntary wheelChronic neuropathic pain modelPaclitaxel-treated miceVehicle-treated miceUnilateral intraplantar injectionLower mechanical thresholdsChronic pain reportQuality of lifeChemotherapy agent paclitaxelImpact of sexDifferent mouse strainsCCI miceCCI surgeryConstriction injuryIntraplantar injectionSham surgeryMale C57BL/6JNovel analgesics
2019
Assessing nicotine dependence using an oral nicotine free-choice paradigm in mice
Bagdas D, Diester C, Riley J, Carper M, Alkhlaif Y, AlOmari D, Alayoubi H, Poklis J, Damaj M. Assessing nicotine dependence using an oral nicotine free-choice paradigm in mice. Neuropharmacology 2019, 157: 107669. PMID: 31220484, PMCID: PMC6697382, DOI: 10.1016/j.neuropharm.2019.107669.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AddictiveChoice BehaviorDose-Response Relationship, DrugDrug InteractionsFemaleMaleMiceMice, KnockoutNicotineNucleus AccumbensQuinineReceptors, NicotinicSelf AdministrationSex CharacteristicsSubstance Withdrawal SyndromeTobacco Use DisorderTyrosine 3-MonooxygenaseVareniclineConceptsAddictive-like propertiesNicotine intakeOral nicotine consumptionNicotine consumptionFree-choice paradigmNicotine solutionΑ6 KO miceTwo-bottle free-choice paradigmTyrosine hydroxylase levelsNicotinic acetylcholine receptor subunitsPartial agonist vareniclineOral nicotine intakeAbsence of nicotineAcetylcholine receptor subunitsΑ5 nAChRAdult C57BL/6JNicotine withdrawalKO miceFemale miceAgonist vareniclineDBA/2J miceHydroxylase levelsNicotine dependenceBinge drinkingObserved sex differences