2024
In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCognitive DysfunctionCOVID-19DeliriumFemaleHospitalizationHumansMaleMiddle AgedProspective StudiesSARS-CoV-2ConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcomeAssociations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults
Lee S, McAvay G, Geda M, Chattopadhyay S, Acampora D, Araujo K, Charpentier P, Gill T, Hajduk A, Cohen A, Ferrante L. Associations of Social Support With Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults. The Journals Of Gerontology Series A 2024, 79: glae092. PMID: 38558166, PMCID: PMC11059296, DOI: 10.1093/gerona/glae092.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCOVID-19FemaleHospitalizationHumansMaleMental HealthMiddle AgedProspective StudiesSARS-CoV-2Social SupportConceptsLow social supportMental health symptomsSocial supportSymptom burdenHealth symptomsFollow-up assessmentCOVID-19 hospitalizationMedical Outcomes Study Social Support SurveyPhysical symptomsAssociation of social supportEdmonton Symptom Assessment SystemPatient Health Questionnaire-4Burden of physical symptomsMental health symptom burdenModified Edmonton Symptom Assessment SystemSocial Support SurveyParticipants' mean ageAssociated with higher burdenSupport SurveyOlder survivorsSymptom managementOlder AdultsMental healthHispanic ethnicityLongitudinal associations
2022
Rationale, Design, and Characteristics of the VALIANT (COVID‐19 in Older Adults: A Longitudinal Assessment) Cohort
Cohen A, McAvay G, Geda M, Chattopadhyay S, Lee S, Acampora D, Araujo K, Charpentier P, Gill T, Hajduk A, Ferrante L. Rationale, Design, and Characteristics of the VALIANT (COVID‐19 in Older Adults: A Longitudinal Assessment) Cohort. Journal Of The American Geriatrics Society 2022, 71: 832-844. PMID: 36544250, PMCID: PMC9877652, DOI: 10.1111/jgs.18146.Peer-Reviewed Original ResearchMeSH KeywordsAftercareAgedCOVID-19FemaleHospitalizationHumansMalePatient DischargeProspective StudiesConceptsPatient-centered outcomesCOVID-19 hospitalizationCognitive impairmentPhysical functionOlder COVID-19 survivorsCOVID-19-related symptomsCOVID-19Older adultsIntensive care unitCOVID-19 survivorsPersistent cognitive impairmentSix-month followMost older adultsThird of participantsElectronic health recordsStepdown unitAcute illnessBurdensome symptomsCare unitSupplemental oxygenMedian lengthProspective studyMean ageBlack raceBaseline interview
2003
The effects of a targeted multicomponent delirium intervention on postdischarge outcomes for hospitalized older adults
Bogardus ST, Desai MM, Williams CS, Leo-Summers L, Acampora D, Inouye SK. The effects of a targeted multicomponent delirium intervention on postdischarge outcomes for hospitalized older adults. The American Journal Of Medicine 2003, 114: 383-390. PMID: 12714128, DOI: 10.1016/s0002-9343(02)01569-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedDeliriumHumansOutcome Assessment, Health CarePatient DischargeProspective StudiesRisk FactorsTime FactorsConceptsSelf-rated healthFunctional statusIntervention groupMulticomponent interventionBetter functional statusHigh-risk patientsGood self-rated healthHospital-based interventionsHospitalized older adultsHealth care utilizationHigh-risk subgroupsHome health visitsOutcomes 6 monthsNursing home placementAcademic medical centerDelirium interventionPostdischarge outcomesHospital dischargeHealth visitsCare utilizationRisk factorsMedical CenterControl groupCognitive statusBeneficial effects
2001
Multicomponent Targeted Intervention to Prevent Delirium in Hospitalized Older Patients
Rizzo J, Bogardus S, Leo-Summers L, Williams C, Acampora D, Inouye S. Multicomponent Targeted Intervention to Prevent Delirium in Hospitalized Older Patients. Medical Care 2001, 39: 740-752. PMID: 11458138, DOI: 10.1097/00005650-200107000-00010.Peer-Reviewed Original ResearchConceptsHospitalized older personsOlder personsIntermediate riskRisk groupsHigh riskRisk factor intervention strategyCost-effective treatment optionHospitalized Older PatientsIntermediate-risk cohortPrevention of deliriumUsual hospital careIntermediate-risk groupOverall health care costsAcute confusional stateEffective treatment optionHigh-risk groupHealth care costsDelirium preventionPrevent DeliriumUsual careHospital daysOlder PatientsHospitalized patientsConfusional stateRisk cohort
1999
A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients
Inouye S, Bogardus S, Charpentier P, Leo-Summers L, Acampora D, Holford T, Cooney L. A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients. New England Journal Of Medicine 1999, 340: 669-676. PMID: 10053175, DOI: 10.1056/nejm199903043400901.Peer-Reviewed Original ResearchConceptsSeverity of deliriumRisk factorsCognitive impairmentRecurrence rateIntervention groupRisk factor intervention strategyHearing impairmentVisual impairmentHospitalized Older PatientsPatients 70 yearsPrevention of deliriumUsual care unitsUsual care groupGeneral medicine serviceEffective treatment strategiesDuration of episodesPrevent DeliriumOlder patientsRate of usePrimary outcomeSleep medicationPoor outcomePrimary preventionPatient's deliriumTeaching hospital
1993
The Yale Geriatric Care Program: A Model of Care To Prevent Functional Decline in Hospitalized Elderly Patients
Inouye S, Acampora D, Miller R, Fulmer T, Hurst L, Cooney L. The Yale Geriatric Care Program: A Model of Care To Prevent Functional Decline in Hospitalized Elderly Patients. Journal Of The American Geriatrics Society 1993, 41: 1345-1352. PMID: 8227918, DOI: 10.1111/j.1532-5415.1993.tb06486.x.Peer-Reviewed Original ResearchConceptsGeriatric care programResource nursesCare programGeriatric care teamsGerontological nurse specialistsPrevent Functional DeclineFrail older patientsAdjustment of medicationsHospitalized elderly patientsStandard nursing carePressure ulcer treatmentUniversity Teaching HospitalAcute care hospitalsModel of careNursing center modelElderly patientsOlder patientsProspective cohortBowel problemsGeriatric physiciansNurse specialistsNursing shiftsPrimary nurseSurgical unitCare teamA Controlled Trial of a Nursing‐Centered Intervention in Hospitalized Elderly Medical Patients: The Yale Geriatric Care Program
Inouye S, Wagner D, Acampora D, Horwitz R, Cooney L, Tinetii M. A Controlled Trial of a Nursing‐Centered Intervention in Hospitalized Elderly Medical Patients: The Yale Geriatric Care Program. Journal Of The American Geriatrics Society 1993, 41: 1353-1360. PMID: 8227919, DOI: 10.1111/j.1532-5415.1993.tb06487.x.Peer-Reviewed Original ResearchConceptsElderly medical patientsFunctional declineMedical patientsBeneficial effectsIntervention groupRelative riskHospitalized elderly medical patientsGeriatric care teamsFrail older patientsProspective cohort studyGeneral medicine wardsUniversity Teaching HospitalGeriatric care programSignificant beneficial effectIntervention patientsADL scoresCohort studyOlder patientsMedicine wardsControl subjectsHospital costsCare teamTeaching hospitalPhysical therapyStratified analysisA predictive index for functional decline in hospitalized elderly medical patients
Inouye S, Wagner D, Acampora D, Horwitz R, Cooney L, Hurst L, Tinetti M. A predictive index for functional decline in hospitalized elderly medical patients. Journal Of General Internal Medicine 1993, 8: 645-652. PMID: 8120679, DOI: 10.1007/bf02598279.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overChi-Square DistributionCohort StudiesConnecticutFemaleGeriatric AssessmentHospital Bed Capacity, 500 and overHospitals, UniversityHumansLikelihood FunctionsMaleMultivariate AnalysisPrevalenceProportional Hazards ModelsProspective StudiesReproducibility of ResultsRisk FactorsSingle-Blind MethodConceptsFunctional declineRisk factorsMedical patientsValidation cohortDevelopment cohortHospitalized elderly medical patientsIndependent baseline risk factorsLow social activity levelNumber of RFsPredictive indexBaseline risk factorsGeneral medical wardsProspective cohort studyGeneral medical patientsHigh-risk groupUniversity Teaching HospitalElderly medical patientsRisk stratification systemNursing home placementRate of deathSocial activity levelsComparable patientsCohort studyElderly patientsMedical wardsPredictors of Formal Home Health Care Use in Elderly Patients after Hospitalization
Solomon D, Wagner D, Marenberg M, Acampora D, Cooney L, Inouye S. Predictors of Formal Home Health Care Use in Elderly Patients after Hospitalization. Journal Of The American Geriatrics Society 1993, 41: 961-966. PMID: 8409182, DOI: 10.1111/j.1532-5415.1993.tb06762.x.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedAged, 80 and overComorbidityConfidence IntervalsEducational StatusFemaleForecastingGeriatric AssessmentHealth PlanningHealth Services ResearchHome Care ServicesHospitalizationHumansMalePatient DischargePatient ReadmissionProportional Hazards ModelsProspective StudiesRisk FactorsSeverity of Illness IndexSocial SupportConceptsHome health care useHealth care useRisk factorsAcute careElderly patientsSurgical patientsCare useHHC useProspective cohort studyRisk factor presentUniversity Teaching HospitalCohort studyHospital dischargeMedian durationIndependent predictorsSurgical wardsRisk strataDischarge planningTeaching hospitalInstrumental activitiesDaily livingElderly populationHHC agenciesStudy catchment areaPatients
1988
A Computer Protocol to Predict Myocardial Infarction in Emergency Department Patients with Chest Pain
Goldman L, Cook E, Brand D, Lee T, Rouan G, Weisberg M, Acampora D, Stasiulewicz C, Walshon J, Terranova G, Gottlieb L, Kobernick M, Goldstein-Wayne B, Copen D, Daley K, Brandt A, Jones D, Mellors J, Jakubowski R. A Computer Protocol to Predict Myocardial Infarction in Emergency Department Patients with Chest Pain. New England Journal Of Medicine 1988, 318: 797-803. PMID: 3280998, DOI: 10.1056/nejm198803313181301.Peer-Reviewed Original ResearchConceptsCoronary care unitAdmission of patientsCare unitMyocardial infarctionUnaided physiciansChest painAcute chest painAbsence of infarctionEmergency department patientsCareful clinical judgmentPresence of infarctionDepartment patientsIntensive careEmergent complicationsUniversity HospitalAppropriate triageCommunity hospitalClinical dataInfarctionPatientsClinical judgmentAdmissionHospitalPhysiciansPain
1987
Clinical characteristics and natural history of patients with acute myocardial infarction sent home from the emergency room
Lee T, Rouan G, Weisberg M, Brand D, Acampora D, Stasiulewicz C, Walshon J, Terranova G, Gottlieb L, Goldstein-Wayne B, Copen D, Daley K, Brandt A, Mellors J, Jakubowski R, Cook E, Goldman L. Clinical characteristics and natural history of patients with acute myocardial infarction sent home from the emergency room. The American Journal Of Cardiology 1987, 60: 219-224. PMID: 3618483, DOI: 10.1016/0002-9149(87)90217-7.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionEmergency roomMissed Acute Myocardial InfarctionPrior acute myocardial infarctionShort-term mortality rateProspective multicenter investigationAcute chest painIschemic electrocardiographic changesAdmission of patientsEmergency room patientsChest painIschemic painClinical characteristicsElectrocardiographic evidencePersistent symptomsAMI patientsElectrocardiographic changesMulticenter investigationSame hospitalTypical presentationRoom patientsIndependent reviewersPatientsMortality rateSensitivity of routine clinical criteria for diagnosing myocardial infarction within 24 hours of hospitalization.
Lee T, Rouan G, Weisberg M, Brand D, Cook E, Acampora D, Goldman L. Sensitivity of routine clinical criteria for diagnosing myocardial infarction within 24 hours of hospitalization. Annals Of Internal Medicine 1987, 106: 181-6. PMID: 3800180, DOI: 10.7326/0003-4819-106-2-181.Peer-Reviewed Original ResearchConceptsRecurrent ischemic painHours of admissionMyocardial infarctionIschemic painChest painEnzyme abnormalitiesDiagnostic criteriaRecurrent chest painAcute chest painHours of hospitalizationIntermediate care unitRoutine clinical criteriaCare unitClinical criteriaCommunity hospitalInfarctionPainPatientsEnzyme testingAdmissionAbnormalitiesIndependent testing setHoursSufficient periodHospitalization