2022
Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome
Morand-Beaulieu S, Crowley MJ, Grantz H, Leckman JF, Scahill L, Sukhodolsky DG. Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome. Clinical Neurophysiology 2022, 142: 75-85. PMID: 35987093, DOI: 10.1016/j.clinph.2022.07.500.Peer-Reviewed Original ResearchConceptsClinical Global Impressions-Improvement scaleYale Global Tic Severity ScaleComprehensive Behavioral InterventionGo/NoGo taskTourette syndromeTreatment outcomesEEG coherenceTic severityNoGo taskBehavioral interventionsFirst-line treatmentTic Severity ScaleClinical outcomesMotor areaSeverity ScaleAlpha frequency bandBlinded evaluatorsTic controlMotor responseEEG biomarkersOutcomesSyndromeBrain mechanismsSeverityIntervention
2021
Electrophysiological signatures of inhibitory control in children with Tourette syndrome and attention-deficit/hyperactivity disorder
Morand-Beaulieu S, Smith SD, Ibrahim K, Wu J, Leckman JF, Crowley MJ, Sukhodolsky DG. Electrophysiological signatures of inhibitory control in children with Tourette syndrome and attention-deficit/hyperactivity disorder. Cortex 2021, 147: 157-168. PMID: 35042055, PMCID: PMC8816877, DOI: 10.1016/j.cortex.2021.12.006.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderGo/NoGo taskFrontal midline theta oscillationsFrontal midline theta powerEvent-related potentialsNoGo taskHyperactivity disorderInhibitory controlTheta powerTheta oscillationsP300 latencyInhibitory control abilitiesDense-array EEG recordingsDistinct electrophysiological profileTourette syndromeNeural underpinningsElectrophysiological correlatesTask performanceBehavioral performanceElectrophysiological signaturesP300 componentBrain activityN200Control abilityTask
2016
Neural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward
Sukhodolsky DG, Vander Wyk B, Eilbott JA, McCauley SA, Ibrahim K, Crowley MJ, Pelphrey KA. Neural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward. Journal Of Child And Adolescent Psychopharmacology 2016, 26: 38-48. PMID: 26784537, PMCID: PMC4779273, DOI: 10.1089/cap.2015.0164.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyReactive aggressionResearch Domain Criteria (RDoC) constructsSessions of CBTEmotional face perceptionEmotion regulation circuitryBrain-behavior associationsAggressive behaviorFunctional magnetic resonanceFace perceptionNon-RewardTraditional diagnostic categoriesNoGo taskFMRI scanningRDoC constructsElectrophysiological correlatesNeural mechanismsCriterion constructsFunctional neuroimagingBehavioral levelStrategic research prioritiesAge 8AggressionAdolescentsSupportive psychotherapy