Dejan Zecevic, PhD
Senior Research Scientist of Cellular and Molecular PhysiologyCards
About
Titles
Senior Research Scientist of Cellular and Molecular Physiology
Biography
Dejan Zecevic is a Senior Research Scientist at the Department of Cellular and Molecular Physiology, Yale University School of Medicine. He received the PhD in Biophysics from The University of Belgrade, Serbia and was trained in the laboratory of Dr Lawrence Cohen (Yale University) who initiated the field of voltage-sensitive dye recording. Dejan is the pioneer of intracellular voltage-sensitive dye imaging technique, a unique and a cutting edge technology for monitoring electrical signaling in axons, dendrites, and dendritic spines.
Appointments
Cellular & Molecular Physiology
Senior Research ScientistPrimary
Other Departments & Organizations
Education & Training
- PhD
- University of Belgrade (1981)
Research
Overview
Medical Research Interests
Action Potentials; Axons; Dendrites; Dendritic Spines; Excitatory Postsynaptic Potentials; Inhibitory Postsynaptic Potentials; Nervous System; Neurobiology; Neurons; Physiology
Publications
2023
Electrical properties of dendritic spines
Zecevic D. Electrical properties of dendritic spines. Biophysical Journal 2023, 122: 4303-4315. PMID: 37837192, PMCID: PMC10698282, DOI: 10.1016/j.bpj.2023.10.008.Peer-Reviewed Original ResearchConceptsDendritic spinesIntracellular calcium concentration changesCortical pyramidal neuronsExcitatory synaptic transmissionCalcium concentration changesBasal dendritesPyramidal neuronsMushroom spinesSpine synapsesSynaptic transmissionBrain slicesVoltage-sensitive dyeNervous systemSpine neckSignificant physiological roleSynaptic signalingTwo-photon uncagingElectrical compartmentsSpineOnly experimental studiesBiochemical compartmentalizationPhysiological roleDifferent preparationsAnatomical structuresAdequate sensitivity
2022
Action Potential Initiation
Zecevic D, Popovic M. Action Potential Initiation. 2022, 156-161. DOI: 10.1007/978-1-0716-1006-0_237.Peer-Reviewed Original Research
2019
Using holographic illumination to study synaptic signal integration at individual dendritic spines
Weng J, Celis C, Zecevic D. Using holographic illumination to study synaptic signal integration at individual dendritic spines. 2019, 10865: 1086514. DOI: 10.1117/12.2507284.Peer-Reviewed Original ResearchSynaptic signal integrationExcitatory synaptic potentialsDendritic spinesSynaptic potentialsTemporal summationAcute cortical brain slicesIndividual synapsesLayer 5 pyramidal neuronsIndividual excitatory synapsesThin basal dendritesCortical brain slicesVoltage-sensitive dye recordingIndividual dendritic spinesSite of originSensory information processingBasal dendritesPyramidal neuronsExcitatory synapsesBrain slicesRepetitive activationVoltage-sensitive dyeSomatic recordingsSingle synapsesSynaptic signalsIndividual neurons
2017
The stochastic nature of action potential backpropagation in apical tuft dendrites
Short SM, Oikonomou KD, Zhou WL, Acker CD, Popovic MA, Zecevic D, Antic SD. The stochastic nature of action potential backpropagation in apical tuft dendrites. Journal Of Neurophysiology 2017, 118: 1394-1414. PMID: 28566465, PMCID: PMC5558024, DOI: 10.1152/jn.00800.2016.Peer-Reviewed Original ResearchConceptsDendritic CaPyramidal neuronsApical tuftCortical pyramidal neuronsAction potential backpropagationRat brain slicesSpontaneous synaptic inputsDifferent cortical layersVoltage-gated CaAP backpropagationAP burstsGlutamate iontophoresisSynaptic contactsSomatic APsApical trunkAP frequencyBrain slicesDendritic physiologySynaptic inputsCortical layersChannel inactivationLocal NaNeuronsSpike-timing dependent plasticityTrialsImaging membrane potential changes from dendritic spines using computer-generated holography
Tanese D, Weng JY, Zampini V, De Sars V, Canepari M, Rozsa B, Emiliani V, Zecevic D. Imaging membrane potential changes from dendritic spines using computer-generated holography. Neurophotonics 2017, 4: 031211-031211. PMID: 28523281, PMCID: PMC5428833, DOI: 10.1117/1.nph.4.3.031211.Peer-Reviewed Original Research
2016
FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon
Dover K, Marra C, Solinas S, Popovic M, Subramaniyam S, Zecevic D, D’Angelo E, Goldfarb M. FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon. Nature Communications 2016, 7: 12895. PMID: 27666389, PMCID: PMC5052690, DOI: 10.1038/ncomms12895.Peer-Reviewed Original ResearchCentral nervous systemAction potentialsNervous systemSodium action potentialsGranule cell axonsAxon initial segmentCerebellar granule cellsNodes of RanvierCell axonsSomatodendritic membraneVertebrate central nervous systemGranule cellsCerebellar granule cell axonsDistal axonsSpike conductionAxonsSodium channels
2015
Electrical behaviour of dendritic spines as revealed by voltage imaging
Popovic MA, Carnevale N, Rozsa B, Zecevic D. Electrical behaviour of dendritic spines as revealed by voltage imaging. Nature Communications 2015, 6: 8436. PMID: 26436431, PMCID: PMC4594633, DOI: 10.1038/ncomms9436.Peer-Reviewed Original ResearchAction Potential Initiation
Zecevic D, Popovic M. Action Potential Initiation. 2015, 137-142. DOI: 10.1007/978-1-4614-6675-8_237.Peer-Reviewed Original ResearchPioneers in Neurophotonics: Special Section Honoring Professor Lawrence B. Cohen
Salzberg BM, Zecevic D. Pioneers in Neurophotonics: Special Section Honoring Professor Lawrence B. Cohen. Neurophotonics 2015, 2: 021001-021001. PMID: 26157992, PMCID: PMC4487646, DOI: 10.1117/1.nph.2.2.021001.Peer-Reviewed Original ResearchCombining Membrane Potential Imaging with Other Optical Techniques
Jaafari N, Vogt KE, Saggau P, Leslie LM, Zecevic D, Canepari M. Combining Membrane Potential Imaging with Other Optical Techniques. Advances In Experimental Medicine And Biology 2015, 859: 103-125. PMID: 26238050, PMCID: PMC5675139, DOI: 10.1007/978-3-319-17641-3_4.Peer-Reviewed Original ResearchConceptsMembrane potential imagingOptical techniquesPotential imagingUncaging techniquesChannelrhodopsin stimulationVoltage-sensitive dyeVariety of applicationsSpatial mappingElectrical signalsImportant applicationsVoltageFluorescence intensityImagingParticular moleculeSignalsMembrane potential changesGateNovel investigationOptogeneticsMeasurementsIntensityTechniqueCurrent
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Cellular & Molecular Physiology
PO Box 208026, 333 Cedar Street
New Haven, CT 06520-8026
United States