2021
Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019 - Volume 27, Number 8—August 2021 - Emerging Infectious Diseases journal - CDC
Brown SC, Cormier J, Tuan J, Lier AJ, McGuone D, Armstrong PM, Kaddouh F, Parikh S, Landry ML, Gobeske KT. Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019 - Volume 27, Number 8—August 2021 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2021, 27: 2042-2051. PMID: 34289334, PMCID: PMC8314835, DOI: 10.3201/eid2708.203730.Peer-Reviewed Original ResearchA perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model
Costine-Bartell B, Price G, Shen J, McGuone D, Staley K, Duhaime AC. A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model. Neurobiology Of Disease 2021, 154: 105334. PMID: 33753291, PMCID: PMC8135256, DOI: 10.1016/j.nbd.2021.105334.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain injurySeizure durationHemispheric hypodensitySubarachnoid hemorrhageTissue damageSevere typeTraumatic brain injury modelSevere traumatic brain injuryEffects of seizuresSevere brain injuryFocal subarachnoid hemorrhageBrain injury modelHuman infantsPotential therapeutic targetLarge animal modelGray matter regionsPattern of damageMultifactorial injuryNeurologic scoresCortical impactSham injurySeizure inductionIntensive careSubdural hematoma
2018
Development of a Model of Hemispheric Hypodensity (“Big Black Brain”)
Costine-Bartell B, McGuone D, Price G, Crawford E, Keeley K, Munoz-Pareja J, Dodge CP, Staley K, Duhaime AC. Development of a Model of Hemispheric Hypodensity (“Big Black Brain”). Journal Of Neurotrauma 2018, 36: 815-833. PMID: 30039743, PMCID: PMC6387571, DOI: 10.1089/neu.2018.5736.Peer-Reviewed Original ResearchConceptsHemispheric hypodensitySubdural hematomaAbusive head traumaMultiple vascular territoriesMechanism of traumaSevere brain damagePatterns of injuryDeep gray matterSeizure durationHead traumaMultiple injuriesPathological examinationKainic acidSevere seizuresVasogenic edemaBrain damageContralateral sideVascular territoriesCommon findingMetabolic mismatchRelative sparingAnimal modelsRadiological indicatorsCortical ribbonGray matter
2017
Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis
Lam JD, Oh DJ, Wong LL, Amarnani D, Park-Windhol C, Sanchez AV, Cardona-Velez J, McGuone D, Stemmer-Rachamimov AO, Eliott D, Bielenberg DR, van Zyl T, Shen L, Gai X, D'Amore PA, Kim LA, Arboleda-Velasquez JF. Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis. Diabetes 2017, 66: db161035. PMID: 28400392, PMCID: PMC5482092, DOI: 10.2337/db16-1035.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnimalsCell MovementCell ProliferationCore Binding Factor Alpha 2 SubunitDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic RetinopathyDisease Models, AnimalEndothelial CellsFemaleGlucoseHumansImmunohistochemistryMaleMiceMiddle AgedOxygenRetinaRetinal NeovascularizationRNA, MessengerConceptsAberrant retinal angiogenesisHuman retinal microvascular endothelial cellsProliferative diabetic retinopathyOxygen-induced retinopathyFibrovascular membranesRetinal angiogenesisEndothelial cellsRetinal microvascular endothelial cellsType 2 diabetesRetina of miceMicrovascular endothelial cellsVascular endothelial cellsNeovascular tuftsDiabetic retinopathyTranscription factor 1Common causeRUNX1 inhibitionImmunohistochemical stainingAdult populationHigh glucoseType 1RetinopathyProtein expressionTube formationFactor 1
2015
The Subventricular Zone in the Immature Piglet Brain: Anatomy and Exodus of Neuroblasts into White Matter after Traumatic Brain Injury
Costine BA, Missios S, Taylor SR, McGuone D, Smith CM, Dodge CP, Harris BT, Duhaime AC. The Subventricular Zone in the Immature Piglet Brain: Anatomy and Exodus of Neuroblasts into White Matter after Traumatic Brain Injury. Developmental Neuroscience 2015, 37: 115-130. PMID: 25678047, PMCID: PMC4406780, DOI: 10.1159/000369091.Peer-Reviewed Original ResearchConceptsTraumatic brain injurySubventricular zoneWhite matterWhite matter tractsNumber of neuroblastsPostnatal neurogenesisBrain injuryEffects of TBICortical impact modelPostnatal day 14Human infantsGyral white matterNeurogenic precursor cellsYounger age groupsMonths of ageSVZ areaPND 7Contralateral hemisphereGyrencephalic brainGyrencephalic speciesPiglet brainLesion siteLarge lesionsLesion sizeDay 14
2014
Phylogenetic and epidemiologic evidence of multiyear incubation in human rabies
Boland TA, McGuone D, Jindal J, Rocha M, Cumming M, Rupprecht CE, Barbosa TF, de Novaes Oliveira R, Chu CJ, Cole AJ, Kotait I, Kuzmina NA, Yager PA, Kuzmin IV, Hedley‐Whyte E, Brown CM, Rosenthal ES. Phylogenetic and epidemiologic evidence of multiyear incubation in human rabies. Annals Of Neurology 2014, 75: 155-160. PMID: 24038455, PMCID: PMC4118733, DOI: 10.1002/ana.24016.Peer-Reviewed Original Research
2013
Case 1-2013 — A 63-Year-Old Man with Paresthesias and Difficulty Swallowing
Cabot R, Harris N, Rosenberg E, Shepard J, Cort A, Ebeling S, McDonald E, Greer D, Robbins G, Lijewski V, Gonzalez R, McGuone D. Case 1-2013 — A 63-Year-Old Man with Paresthesias and Difficulty Swallowing. New England Journal Of Medicine 2013, 368: 172-180. PMID: 23301735, DOI: 10.1056/nejmcpc1209935.Peer-Reviewed Original Research