2018
Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma
Gopal RK, Calvo SE, Shih AR, Chaves FL, McGuone D, Mick E, Pierce KA, Li Y, Garofalo A, Van Allen EM, Clish CB, Oliva E, Mootha VK. Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e6283-e6290. PMID: 29915083, PMCID: PMC6142220, DOI: 10.1073/pnas.1711888115.Peer-Reviewed Original Research
2015
Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening
Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening. Scientific Reports 2015, 5: 16622. PMID: 26564777, PMCID: PMC4643219, DOI: 10.1038/srep16622.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesBrainCell SurvivalCells, CulturedCytokinesFemaleGene Expression ProfilingGene Regulatory NetworksHumansInflammation MediatorsInterleukin-5Least-Squares AnalysisMaleMiddle AgedMultivariate AnalysisNeuronsRegression AnalysisTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AConceptsCytokine expressionNeuronal deathNeuron culturesAD-associated cytokinesPathologic disease statesDisease tissuesControl brain tissueAlzheimer's disease tissueDisease therapeuticsAlzheimer's disease therapeuticsNeurotoxic cytokinesPro-death effectAD pathogenesisNeuronal viabilityAD tissueAmyloid betaAmyloid hypothesisMinimal efficacyHuman ADSmall cohortPathological severityCytokinesBrain tissueDisease statesVEGF