2022
Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood
Leitner DF, William C, Faustin A, Askenazi M, Kanshin E, Snuderl M, McGuone D, Wisniewski T, Ueberheide B, Gould L, Devinsky O. Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood. Acta Neuropathologica 2022, 143: 585-599. PMID: 35333953, PMCID: PMC8953962, DOI: 10.1007/s00401-022-02414-7.Peer-Reviewed Original ResearchConceptsSudden unexplained deathDentate gyrusFrontal cortexClinical historyCA1-3Unexplained deathBrain regionsSudden unexpected deathHippocampal dentate gyrusFebrile seizure historyAcute phase responseCause of deathYears of ageMechanism of deathCircumstances of deathSUDC casesMolecular signaling pathwaysClinical featuresSeizure historyPathological featuresMultiple etiologiesCornu ammonisUnexpected deathPreventive strategiesAncillary testingNeuropathology of Chiari Malformation II with Chromosome X Alterations: An Autopsy Study in a 17-Month-Old and Review of Literature
Wang X, Habet V, Aboian M, Leelatian N, McGuone D, Morotti R, Kandil S, Darbinyan A. Neuropathology of Chiari Malformation II with Chromosome X Alterations: An Autopsy Study in a 17-Month-Old and Review of Literature. Journal Of Neuropathology & Experimental Neurology 2022, 81: 296-298. PMID: 35139536, DOI: 10.1093/jnen/nlab137.Peer-Reviewed Original Research
2020
Autopsy Services and Emergency Preparedness of a Tertiary Academic Hospital Mortuary for the COVID-19 Public Health Emergency: The Yale Plan
McGuone D, Sinard J, Gill JR, Masters A, Liu C, Morotti R, Parkash V. Autopsy Services and Emergency Preparedness of a Tertiary Academic Hospital Mortuary for the COVID-19 Public Health Emergency: The Yale Plan. Advances In Anatomic Pathology 2020, 27: 355-362. PMID: 32649315, DOI: 10.1097/pap.0000000000000274.Peer-Reviewed Original ResearchConceptsAcute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemicHealth care worker safetyCoronavirus 2 pandemicCOVID-19 public health emergencyHigh-quality patient carePublic health emergencyCorona Virus DiseaseEarly response phaseInfection controlPatient careTissue retrievalAutopsy serviceMortuary servicesHospital mortuaryAutopsiesHealth emergencyPatient flowNovel diseaseVirus diseasePlateau phaseDiseasePandemicRecent memoryEmergency preparedness
2017
Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease
Williams EA, McGuone D, Frosch MP, Hyman BT, Laver N, Stemmer-Rachamimov A. Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease. Journal Of Neuropathology & Experimental Neurology 2017, 76: 376-383. PMID: 28379416, PMCID: PMC7191616, DOI: 10.1093/jnen/nlx020.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseMacular degenerationΒ-amyloidAlzheimer's disease neuropathologic changeAD-related changesAge-matched controlsEyes of subjectsAD-related featuresSeverity of changesAlzheimer changesNeuropathologic changesPathologic findingsAutopsy casesVisual deficitsCommon causeTDP-43Pathology studiesTau proteinExtracellular depositionΑ-synucleinIntracellular accumulationBrainSimilar changesDegenerationDisease
2013
Studying synapses in human brain with array tomography and electron microscopy
Kay KR, Smith C, Wright AK, Serrano-Pozo A, Pooler AM, Koffie R, Bastin ME, Bak TH, Abrahams S, Kopeikina KJ, McGuone D, Frosch MP, Gillingwater TH, Hyman BT, Spires-Jones TL. Studying synapses in human brain with array tomography and electron microscopy. Nature Protocols 2013, 8: 1366-1380. PMID: 23787894, PMCID: PMC3712649, DOI: 10.1038/nprot.2013.078.Peer-Reviewed Original ResearchConceptsHuman brainClinicopathological correlationArray tomographySynapse densityPostmortem studiesPsychiatric illnessClinical cohortAutopsy tissueBrain bankingThousands of synapsesNeurodegenerative diseasesSynapsesUltrastructural studySerial sectionsSynapse levelHuman samplesDiseaseBrainDevelopmental diseasesTomographyLight microscopyUltrathin serial sectionsCohortIllnessPotent way
2011
Autopsy-confirmed, co-existent CADASIL and multiple system atrophy
Rice C, McGuone D, Kurian K, Love S, Renowden S, Giffin N. Autopsy-confirmed, co-existent CADASIL and multiple system atrophy. Parkinsonism & Related Disorders 2011, 17: 390-392. PMID: 21316291, DOI: 10.1016/j.parkreldis.2011.01.004.Peer-Reviewed Original Research
2004
The impact of the organ retention controversy on the practice of hospital necropsy: a four year audit
Mcguone D, Kay E. The impact of the organ retention controversy on the practice of hospital necropsy: a four year audit. Journal Of Clinical Pathology 2004, 57: 448. PMID: 15047757, PMCID: PMC1770284, DOI: 10.1136/jcp.2003.012633.Peer-Reviewed Original Research