2024
Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history
Leitner D, William C, Faustin A, Kanshin E, Snuderl M, McGuone D, Wisniewski T, Ueberheide B, Gould L, Devinsky O. Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history. Acta Neuropathologica 2024, 148: 76. PMID: 39607506, PMCID: PMC11604820, DOI: 10.1007/s00401-024-02832-9.Peer-Reviewed Original ResearchConceptsMedullary rapheSudden infant death syndromeVentrolateral medullaFebrile seizuresSudden unexplained deathWeighted gene correlation network analysisDorsal rapheUnexplained deathMidbrain dorsal rapheSUDC casesSignaling pathwayEukaryotic translation initiationGene Ontology biological processesSynaptic vesicle cycleLabel-free quantitative mass spectrometryEukaryotic translation elongationSudden unexpected deathGene correlation network analysisDifferential expression analysisDecreased cellular respirationFebrile seizure historyQuantitative mass spectrometryAutonomic dysfunctionCorrelation network analysisCoagulation system
2022
Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood
Leitner DF, William C, Faustin A, Askenazi M, Kanshin E, Snuderl M, McGuone D, Wisniewski T, Ueberheide B, Gould L, Devinsky O. Proteomic differences in hippocampus and cortex of sudden unexplained death in childhood. Acta Neuropathologica 2022, 143: 585-599. PMID: 35333953, PMCID: PMC8953962, DOI: 10.1007/s00401-022-02414-7.Peer-Reviewed Original ResearchConceptsSudden unexplained deathDentate gyrusFrontal cortexClinical historyCA1-3Unexplained deathBrain regionsSudden unexpected deathHippocampal dentate gyrusFebrile seizure historyAcute phase responseCause of deathYears of ageMechanism of deathCircumstances of deathSUDC casesMolecular signaling pathwaysClinical featuresSeizure historyPathological featuresMultiple etiologiesCornu ammonisUnexpected deathPreventive strategiesAncillary testing
2020
Sudden Unexplained Death in Childhood: A Neuropathology Review
McGuone D, Crandall LG, Devinsky O. Sudden Unexplained Death in Childhood: A Neuropathology Review. Frontiers In Neurology 2020, 11: 582051. PMID: 33178125, PMCID: PMC7596260, DOI: 10.3389/fneur.2020.582051.Peer-Reviewed Original ResearchSudden unexpected infant deathSudden unexplained deathMedical historyUnexplained deathLife-threatening hypoxiaMedullary serotonergic neuronsMild pathologic changesThorough case investigationUnexplained child deathsFocal cortical dysplasiaUnexpected infant deathFebrile seizure historyAge 12 monthsCause of mortalityChild's medical historyCircumstances of deathSUDC casesSUID deathsSerotonergic nucleiCardiorespiratory controlCortical dysplasiaHippocampal abnormalitiesSeizure historySerotonergic neuronsReflex responsesNeuropathologic Changes in Sudden Unexplained Death in Childhood
McGuone D, Leitner D, William C, Faustin A, Leelatian N, Reichard R, Shepherd TM, Snuderl M, Crandall L, Wisniewski T, Devinsky O. Neuropathologic Changes in Sudden Unexplained Death in Childhood. Journal Of Neuropathology & Experimental Neurology 2020, 79: 336-346. PMID: 31995186, PMCID: PMC7036658, DOI: 10.1093/jnen/nlz136.Peer-Reviewed Original ResearchConceptsSudden unexplained deathHippocampal abnormalitiesUnexplained deathHippocampal findingsNumber of seizuresBoard-certified neuropathologistsCause of deathComprehensive case investigationMultiple chromosomal aberrationsSeizure pathogenesisSUDC casesFebrile seizuresHippocampal alterationsMedian ageHistological reviewNeuropathologic changesNeuropathologic investigationDentate gyrusProne positionCommon findingAncillary testingAutopsy dataMolecular testingApparent sleepBrain samples