Blinded review of hippocampal neuropathology in sudden unexplained death in childhood reveals inconsistent observations and similarities to explained paediatric deaths
Leitner DF, McGuone D, William C, Faustin A, Askenazi M, Snuderl M, Guzzetta M, Jarrell HS, Maloney K, Reichard R, Smith C, Weedn V, Wisniewski T, Gould L, Devinsky O. Blinded review of hippocampal neuropathology in sudden unexplained death in childhood reveals inconsistent observations and similarities to explained paediatric deaths. Neuropathology And Applied Neurobiology 2021, 48: e12746. PMID: 34164845, PMCID: PMC8777468, DOI: 10.1111/nan.12746.Peer-Reviewed Original ResearchConceptsCause of deathSudden unexplained deathHippocampal findingsUnexplained deathBlinded reviewersFebrile seizure historyGranule cell lossForensic pathologistsBoard-certified forensic pathologistsHippocampal histologyHippocampal maldevelopmentFebrile seizuresHippocampal neuropathologyHippocampal sectionsPyramidal neuronsSeizure historyPediatric deathsChildhood casesSudden deathImmunohistological markersBlinded reviewNormal rangeCell lossLarger studySUDC