2021
Seizure‐related deaths in children: The expanding spectrum
Harowitz J, Crandall L, McGuone D, Devinsky O. Seizure‐related deaths in children: The expanding spectrum. Epilepsia 2021, 62: 570-582. PMID: 33586153, PMCID: PMC7986159, DOI: 10.1111/epi.16833.Peer-Reviewed Original ResearchConceptsSeizure-related deathSudden unexpected infant deathSudden unexplained deathUnexpected infant deathEpileptic factorsMale predominanceNonfebrile seizuresHippocampal abnormalitiesFetal lossProne positionUnexplained deathUnexpected deathFamily historyNeuronal excitabilityInfant deathUnwitnessed deathsEpidemiological studiesEpilepsy shareEpilepsy diagnosisDeathGenetic featuresSeizuresChildrenPotential causesFebrile
2020
Sudden Unexplained Death in Childhood: A Neuropathology Review
McGuone D, Crandall LG, Devinsky O. Sudden Unexplained Death in Childhood: A Neuropathology Review. Frontiers In Neurology 2020, 11: 582051. PMID: 33178125, PMCID: PMC7596260, DOI: 10.3389/fneur.2020.582051.Peer-Reviewed Original ResearchSudden unexpected infant deathSudden unexplained deathMedical historyUnexplained deathLife-threatening hypoxiaMedullary serotonergic neuronsMild pathologic changesThorough case investigationUnexplained child deathsFocal cortical dysplasiaUnexpected infant deathFebrile seizure historyAge 12 monthsCause of mortalityChild's medical historyCircumstances of deathSUDC casesSUID deathsSerotonergic nucleiCardiorespiratory controlCortical dysplasiaHippocampal abnormalitiesSeizure historySerotonergic neuronsReflex responsesNeuropathologic Changes in Sudden Unexplained Death in Childhood
McGuone D, Leitner D, William C, Faustin A, Leelatian N, Reichard R, Shepherd TM, Snuderl M, Crandall L, Wisniewski T, Devinsky O. Neuropathologic Changes in Sudden Unexplained Death in Childhood. Journal Of Neuropathology & Experimental Neurology 2020, 79: 336-346. PMID: 31995186, PMCID: PMC7036658, DOI: 10.1093/jnen/nlz136.Peer-Reviewed Original ResearchConceptsSudden unexplained deathHippocampal abnormalitiesUnexplained deathHippocampal findingsNumber of seizuresBoard-certified neuropathologistsCause of deathComprehensive case investigationMultiple chromosomal aberrationsSeizure pathogenesisSUDC casesFebrile seizuresHippocampal alterationsMedian ageHistological reviewNeuropathologic changesNeuropathologic investigationDentate gyrusProne positionCommon findingAncillary testingAutopsy dataMolecular testingApparent sleepBrain samples