A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model
Costine-Bartell B, Price G, Shen J, McGuone D, Staley K, Duhaime AC. A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model. Neurobiology Of Disease 2021, 154: 105334. PMID: 33753291, PMCID: PMC8135256, DOI: 10.1016/j.nbd.2021.105334.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain injurySeizure durationHemispheric hypodensitySubarachnoid hemorrhageTissue damageSevere typeTraumatic brain injury modelSevere traumatic brain injuryEffects of seizuresSevere brain injuryFocal subarachnoid hemorrhageBrain injury modelHuman infantsPotential therapeutic targetLarge animal modelGray matter regionsPattern of damageMultifactorial injuryNeurologic scoresCortical impactSham injurySeizure inductionIntensive careSubdural hematoma