2024
Biodistribution of Polymeric Nanoparticles following In-Utero Delivery to a Non-Human Primate
Eaton D, Lynn A, Surprenant J, Deschenes E, Guerra M, Rivero R, Yung N, O'Connor M, Glazer P, Bahtiyar M, Saltzman W, Stitelman D. Biodistribution of Polymeric Nanoparticles following In-Utero Delivery to a Non-Human Primate. Biomedicine Hub 2024, 1-16. DOI: 10.1159/000543138.Peer-Reviewed Original ResearchMonogenic diseasesNon-human primatesBiodistribution of polymeric nanoparticlesPreclinical mouse modelsStem cell populationFetal liverFetal malesSystemic deliveryFetal bonesAccumulation of NPIn-uteroMid-gestationNP accumulationBiodistribution studiesPolymeric NPsTherapeutic accessCell populationsMaternal tissuesZone of proliferationPolymeric nanoparticlesDiseaseBirthMiceDeliveryBiodistribution
2009
The developmental stage determines the distribution and duration of gene expression after early intra-amniotic gene transfer using lentiviral vectors
Endo M, Henriques-Coelho T, Zoltick PW, Stitelman DH, Peranteau WH, Radu A, Flake AW. The developmental stage determines the distribution and duration of gene expression after early intra-amniotic gene transfer using lentiviral vectors. Gene Therapy 2009, 17: 61-71. PMID: 19727133, DOI: 10.1038/gt.2009.115.Peer-Reviewed Original ResearchConceptsGene transferAccessible stem cell populationGene expressionDevelopmental stagesEarly gestational time pointsGene expression correspondsStem cell populationGreen fluorescent protein expressionTissue expressionCell populationsFluorescent protein expressionEarly somite stagesEpithelial cellsGerm layersLentiviral vectorsOnly epithelial cellsDevelopmental diseasesNeural ectodermGFP expressionSomite stageEfficient gene transferExpression correspondsProtein expressionEctodermGestational time points