2000
Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values?
Trout S, Seifer D. Do women with unexplained recurrent pregnancy loss have higher day 3 serum FSH and estradiol values? Fertility And Sterility 2000, 74: 335-337. PMID: 10927054, DOI: 10.1016/s0015-0282(00)00625-7.Peer-Reviewed Original ResearchConceptsDay 3 serum FSHRecurrent pregnancy lossUnexplained recurrent pregnancy lossCauses of RPLSerum FSHPregnancy lossControl groupOvarian reserveDay 3 FSHUnexplained habitual abortionDiminished ovarian reservePresence of infertilityHistory of infertilityRetrospective comparative analysisUnexplained groupRPL groupHabitual abortionMean ageMAIN OUTCOMEFSHGreater incidenceTest groupWomenPotential roleInfertility
1997
Day 3 serum inhibin-B is predictive of assisted reproductive technologies outcome
Seifer D, Lambert-Messerlian G, Hogan J, Gárdiner A, Blazar A, Berk C. Day 3 serum inhibin-B is predictive of assisted reproductive technologies outcome. Fertility And Sterility 1997, 67: 110-114. PMID: 8986693, DOI: 10.1016/s0015-0282(97)81865-1.Peer-Reviewed Original ResearchConceptsClinical pregnancy rateNumber of oocytesSerum inhibin B concentrationPg/mLInhibin B concentrationsSerum inhibinPregnancy ratePg/Clinical pregnancyOvulation inductionSerum E2Poor responseCancellation rateDay 3 serum FSHAssisted reproductive technology cyclesGnRH agonist suppressionInhibin B valuesReproductive technology cyclesDay of hCGSpontaneous abortion rateAcademic clinical practiceReproductive technologiesSerum FSHOdds ratioE2 response
1996
Apoptosis as a function of ovarian reserve in women undergoing in vitro fertilization*†
Seifer D, Gardiner A, Ferreira K, Peluso J. Apoptosis as a function of ovarian reserve in women undergoing in vitro fertilization*†. Fertility And Sterility 1996, 66: 593-598. PMID: 8816622, DOI: 10.1016/s0015-0282(16)58573-2.Peer-Reviewed Original ResearchConceptsDay 3 serum FSHFSH levelsOvarian reserveSerum FSHMIU/Granulosa cellsCell countDiminished ovarian reserveMIU/mLAcademic clinical practiceLuteinized granulosa cellsApoptotic granulosa cellsIVF-ETFollicular aspiratesPreovulatory folliclesClinical practiceFlow cytometryWomenMean numberApoptotic cellsFSHGreater percentageFolliclesCellsViable cellsDifferential secretion of dimeric inhibin in cultured luteinized granulosa cells as a function of ovarian reserve
Seifer DB, Gardiner AC, Lambert-Messerlian G, Schneyer AL. Differential secretion of dimeric inhibin in cultured luteinized granulosa cells as a function of ovarian reserve. The Journal Of Clinical Endocrinology & Metabolism 1996, 81: 736-739. PMID: 8636296, DOI: 10.1210/jcem.81.2.8636296.Peer-Reviewed Original ResearchConceptsDay 3 serum FSHLuteinized granulosa cellsHigh FSH groupDimeric inhibinSerum FSHFSH groupPg/Granulosa cellsFSH levelsOvarian reserveOvulation inductionProgesterone concentrationsDay 3 serum FSH levelsCultured luteinized granulosa cellsDimeric inhibin productionLow FSH groupSerum FSH levelsFertilization-embryo transferHigher FSH levelsReproductive technology programGranulosa cell levelTotal inhibinInhibin concentrationsInhibin productionProspective study
1992
Flow cytometric analysis of deoxyribonucleic acid in human granulosa cells as a function of chronological age and ovulation induction regimen
Seifer DB, Honig J, Penzias AS, Lavy G, Nadkarni PM, Jones EE, DeCherney AH, Flynn SD. Flow cytometric analysis of deoxyribonucleic acid in human granulosa cells as a function of chronological age and ovulation induction regimen. The Journal Of Clinical Endocrinology & Metabolism 1992, 75: 636-640. PMID: 1639962, DOI: 10.1210/jcem.75.2.1639962.Peer-Reviewed Original ResearchConceptsHuman menopausal gonadotropinOvulation induction regimenGreater proliferative indexInduction regimenLeuprolide acetateProliferative indexGranulosa cellsGroup IGroup IIGroup IIIAmpules of hMGFunction of ageFlow cytometryDay of hCGProspective cohort studyGroup of patientsHuman granulosa cellsChronological ageMenopausal gonadotropinCohort studyOvulation inductionSerum FSHSignificant independent influenceOutcome measuresWomen's age