2005
Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines
Dwyer-Nield L, Srebernak M, Barrett B, Ahn J, Cosper P, Meyer A, Kisley L, Bauer A, Thompson D, Malkinson A. Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines. Carcinogenesis 2005, 26: 1196-1206. PMID: 15746162, DOI: 10.1093/carcin/bgi061.Peer-Reviewed Original ResearchConceptsMouse lung epithelial cell lineLung epithelial cell lineInducible NO synthaseBiosynthetic enzymesEpithelial cell lineCell linesProstaglandin E2Lung tumor-derived cell linesTumor-derived cell linesNon-tumorigenic linesNitric oxidePG biosynthetic enzymesCytokine exposureInhibition of iNOSNormal lung cellsCyclooxygenase-2 activityPhysiological relevanceLung tumor formationLung tumor growthMouse lung tumorsSpontaneous transformantsTumor formationCritical mediatorControl lungsEpithelial cells
2002
Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice
Kisley L, Barrett B, Dwyer-Nield L, Bauer A, Thompson D, Malkinson A. Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice. Carcinogenesis 2002, 23: 1653-1660. PMID: 12376474, DOI: 10.1093/carcin/23.10.1653.Peer-Reviewed Original ResearchConceptsNon-steroidal anti-inflammatory drugsLung tumor formationPulmonary inflammationLung tumorigenesisLung tumorsMacrophage infiltrationPGE2 productionTumor formationMice fed control dietCOX-2-specific inhibitorsTwo-stage carcinogenesis protocolCelecoxib-treated miceLung cancer developmentAnti-inflammatory drugsProduction of eicosanoidsFed control dietCyclooxygenase-enzyme expressionDifferent organ systemsChronic administrationPGE2 levelsVascular leakageClinical trialsCarcinogenesis protocolMurine modelHigh risk