2013
Beyond Burst Pressure: Initial Evaluation of the Natural History of the Biaxial Mechanical Properties of Tissue-Engineered Vascular Grafts in the Venous Circulation Using a Murine Model
Naito Y, Lee YU, Yi T, Church SN, Solomon D, Humphrey JD, Shin'oka T, Breuer CK. Beyond Burst Pressure: Initial Evaluation of the Natural History of the Biaxial Mechanical Properties of Tissue-Engineered Vascular Grafts in the Venous Circulation Using a Murine Model. Tissue Engineering Part A 2013, 20: 346-355. PMID: 23957852, PMCID: PMC3875183, DOI: 10.1089/ten.tea.2012.0613.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaBlood CirculationBlood Vessel ProsthesisExtracellular MatrixFibrillin-1FibrillinsImplants, ExperimentalMatrix Metalloproteinase 2Matrix Metalloproteinase 9MiceMice, SCIDMicrofilament ProteinsModels, AnimalPressureTissue EngineeringTissue ScaffoldsVena Cava, InferiorConceptsTissue-engineered vascular graftsMechanical propertiesBiaxial propertiesNeotissue formationBiaxial mechanical propertiesWeeks of implantationVascular graftsBurst pressureBiodegradable scaffoldsVascular neotissue formationMicrostructural compositionMechanobiological principlesPropertiesGreat promiseBenchDeposition
2011
Vascular tissue engineering: Towards the next generation vascular grafts
Naito Y, Shinoka T, Duncan D, Hibino N, Solomon D, Cleary M, Rathore A, Fein C, Church S, Breuer C. Vascular tissue engineering: Towards the next generation vascular grafts. Advanced Drug Delivery Reviews 2011, 63: 312-323. PMID: 21421015, DOI: 10.1016/j.addr.2011.03.001.Peer-Reviewed Original ResearchConceptsBone marrow-derived mononuclear cellsClinical trialsAutologous bone marrow-derived mononuclear cellsNext-generation vascular graftsMarrow-derived mononuclear cellsVascular graftsExcellent safety profileFirst clinical trialRisk of infectionBiodegradable tubular scaffoldsTissue engineering technologyPrimary graftSafety profileMononuclear cellsCardiovascular diseaseTubular scaffoldsCardiovascular surgeryGraftSynthetic vascular graftsVascular neotissue formationNeotissue formationContinued investigationTEVGsEngineering technologyTrials