2018
Cell Autonomous and Non-cell Autonomous Regulation of SMC Progenitors in Pulmonary Hypertension
Sheikh AQ, Saddouk FZ, Ntokou A, Mazurek R, Greif DM. Cell Autonomous and Non-cell Autonomous Regulation of SMC Progenitors in Pulmonary Hypertension. Cell Reports 2018, 23: 1152-1165. PMID: 29694892, PMCID: PMC5959296, DOI: 10.1016/j.celrep.2018.03.043.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionMyeloid cellsPlatelet-derived growth factor receptor βGrowth factor receptor βKruppel-like factor 4Muscle cell markersAttractive therapeutic targetHypoxia-inducible factor-1Vascular muscularizationDistal migrationNormal lungSmall arteriolesMuscle expansionHypertensionTherapeutic targetNon-cell autonomous pathwaysReceptor βCell expressionCell inductionCell markersSMC progenitorsEndothelial cellsFactor 1Factor 4Muscularization
2015
Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension
Sheikh AQ, Misra A, Rosas IO, Adams RH, Greif DM. Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension. Science Translational Medicine 2015, 7: 308ra159. PMID: 26446956, PMCID: PMC4629985, DOI: 10.1126/scitranslmed.aaa9712.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansHypertension, PulmonaryImmunohistochemistryKruppel-Like Factor 4Kruppel-Like Transcription FactorsMiceMice, Inbred C57BLMuscle, Smooth, VascularMyocytes, Smooth MuscleStem CellsConceptsSmooth muscle cellsKruppel-like factor 4Pulmonary hypertensionSmooth muscleHypoxia-induced pulmonary hypertensionPathogenesis of PHPulmonary artery blood pressureSMC progenitorsArteriole smooth muscleArtery blood pressureSmooth muscle cell progenitorsCardiovascular disease pathogenesisPlatelet-derived growth factor receptorHypoxia-induced expressionGrowth factor receptorPH patientsBlood pressurePulmonary arteriolesVascular disordersTherapeutic strategiesDisease pathogenesisKLF4 levelsKLF4 expressionDistal extensionMuscle cells
2004
KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation
SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA, García-Cardeña G, Jain MK. KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation. Journal Of Experimental Medicine 2004, 199: 1305-1315. PMID: 15136591, PMCID: PMC2211816, DOI: 10.1084/jem.20031132.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCells, CulturedDNA PrimersEndothelium, VascularE-SelectinGene Expression RegulationGlutathione TransferaseHumansInflammationIntercellular Adhesion Molecule-1Interleukin-1Kruppel-Like Transcription FactorsNF-kappa BNitric Oxide SynthaseNitric Oxide Synthase Type IIIOligonucleotide Array Sequence AnalysisPolymerase Chain ReactionPromoter Regions, GeneticStress, MechanicalTrans-ActivatorsTranscription, GeneticUmbilical VeinsZinc FingersConceptsUmbilical vein endothelial cellsVein endothelial cellsProinflammatory cytokinesEndothelial nitric oxide synthase expressionVascular cell adhesion molecule-1Nitric oxide synthase expressionInflammatory cytokines interleukin-1betaEndothelial cellsCell adhesion molecule-1Endothelial proinflammatory activationOxide synthase expressionCultured human umbilical vein endothelial cellsCytokine interleukin-1betaVascular disease statesEndothelial adhesion molecules EAdhesion molecule-1Adhesion molecules EOverexpression of KLF2Human umbilical vein endothelial cellsAMP response element binding proteinCyclic AMP response element binding proteinResponse element-binding proteinT cell attachmentEndothelial functionEndothelial activation