Da Li
Associate Professor AdjunctCards
About
Research
Publications
2024
Epigenetics-targeted drugs: current paradigms and future challenges
Dai W, Qiao X, Fang Y, Guo R, Bai P, Liu S, Li T, Jiang Y, Wei S, Na Z, Xiao X, Li D. Epigenetics-targeted drugs: current paradigms and future challenges. Signal Transduction And Targeted Therapy 2024, 9: 332. PMID: 39592582, PMCID: PMC11627502, DOI: 10.1038/s41392-024-02039-0.Peer-Reviewed Original ResearchConceptsNon-coding RNA regulationDNA base sequenceRNA modificationsRNA regulationChromatin remodelingHistone modificationsEnhancer of zeste homolog 2Epigenetic landscapeGenetic informationOrganismal developmentDNA methyltransferasesEpigenetic enzymesDNA modificationsBase sequenceHomolog 2Zeste homolog 2Histone deacetylasesHuman diseasesIsocitrate dehydrogenaseDNAPathological contextsRegulatory systemChromatinEnzymeHistoneTET3-overexpressing macrophages promote endometriosis
Lv H, Liu B, Dai Y, Li F, Bellone S, Zhou Y, Mamillapalli R, Zhao D, Venkatachalapathy M, Hu Y, Carmichael G, Li D, Taylor H, Huang Y. TET3-overexpressing macrophages promote endometriosis. Journal Of Clinical Investigation 2024, 134: e181839. PMID: 39141428, PMCID: PMC11527447, DOI: 10.1172/jci181839.Peer-Reviewed Original ResearchDisease-associated macrophagesTET3 overexpressionHuman endometriosis lesionsPathophysiology of endometriosisPro-inflammatory cytokine productionChronic inflammatory diseaseReproductive age womenEndometriosis lesionsE3 ubiquitin ligasePathogenic macrophagesCytokine productionEndometriosisInflammatory diseasesTET3 knockdownEndometriosis progressionPathogenic contributorsLet-7 miRNA expressionAge womenMacrophagesMouse macrophagesTherapeutic targetUbiquitin ligaseTET3MiceDiseaseAssociation of uric acid and fructose levels in polycystic ovary syndrome
Feng D, Wang X, Song J, Yang H, Peng Y, Wang X, Chen W, Li P, Fang Y, Shi B, Li D. Association of uric acid and fructose levels in polycystic ovary syndrome. Human Reproduction 2024, 39: 2575-2586. PMID: 39380170, DOI: 10.1093/humrep/deae219.Peer-Reviewed Original ResearchPolycystic ovary syndromeSerum uric acidUric acid levelsSerum fructose levelsSerum uric acid levelsIndependent risk factorDiagnosis of polycystic ovary syndromeClinical diagnosis of polycystic ovary syndromeMetabolic disordersGranulosa cellsReal-time PCRControl womenShengjing HospitalMetabolic syndromeUric acidElevated serum uric acid levelsQuantitative real-time PCRRisk factorsAssociation of uric acidShengjing Hospital of China Medical UniversityAcid levelsInsulin resistanceIncreased risk of anovulationFructose metabolismHospital of China Medical UniversityBioengineering approaches for the endometrial research and application
Dai W, Liang J, Guo R, Zhao Z, Na Z, Xu D, Li D. Bioengineering approaches for the endometrial research and application. Materials Today Bio 2024, 26: 101045. PMID: 38600921, PMCID: PMC11004221, DOI: 10.1016/j.mtbio.2024.101045.Peer-Reviewed Original ResearchInvestigation of regulatory factorsDefect in vitroHuman endometriumEndometrial injuryGynecological complicationsOvarian hormonesEndometrial regenerationEndometriumTherapeutic methodsEndometrial researchConstitutive cellsTissue bioengineeringWound healingRegulatory factorsBiomechanical propertiesBioengineering approachesFemale reproductive potentialExtracellular matrixLow-input lipidomics reveals lipid metabolism remodelling during early mammalian embryo development
Zhang L, Zhao J, Lam S, Chen L, Gao Y, Wang W, Xu Y, Tan T, Yu H, Zhang M, Liao X, Wu M, Zhang T, Huang J, Li B, Zhou Q, Shen N, Lee H, Ye C, Li D, Shui G, Zhang J. Low-input lipidomics reveals lipid metabolism remodelling during early mammalian embryo development. Nature Cell Biology 2024, 26: 278-293. PMID: 38302721, DOI: 10.1038/s41556-023-01341-3.Peer-Reviewed Original ResearchConceptsMammalian preimplantation embryo developmentEmbryo developmentIn vitro blastocyst developmentPreimplantation embryo developmentEight-cell embryosMammalian early embryonic developmentMammalian embryo developmentDegree of phospholipid unsaturationEarly embryo developmentApical-basal polarityBlastocyst developmentBlastocyst stageLipid metabolism remodelingHuman early embryo developmentBlastocyst implantationRegulation of embryogenesisEarly embryonic developmentBlastocystLipid landscapeApical proteinsLipid desaturasesMetabolic remodelingCell signalingPlasma membraneLipid signaturesSkeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α
Liu B, Xie D, Huang X, Jin S, Dai Y, Sun X, Li D, Bennett A, Diano S, Huang Y. Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α. Diabetologia 2024, 67: 724-737. PMID: 38216792, PMCID: PMC10904493, DOI: 10.1007/s00125-023-06073-5.Peer-Reviewed Original ResearchConceptsTen-eleven translocationMuscle insulin sensitivityRNA-seqPGC-1aRegulation of muscle insulin sensitivityType 2 diabetesAnalysis of RNA-seqResponse to environmental cuesGenome-wide expression profilingWild-typeHFD-fedHFD-induced insulin resistanceHigh-fat diet (HFD)-inducedExpression levelsMaintenance of glucoseSkeletal muscle insulin sensitivityAccession numbersSkeletal muscleEnhanced glucose toleranceFamily dioxygenasesMitochondrial respirationSkeletal muscle of humansEnvironmental cuesMitochondrial functionBiological processes
2023
Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production
Song J, Lv H, Liu B, Hao M, Taylor H, Zhang X, Li D, Huang Y. Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production. Molecular Metabolism 2023, 78: 101828. PMID: 37898449, PMCID: PMC10641683, DOI: 10.1016/j.molmet.2023.101828.Peer-Reviewed Original ResearchConceptsFas-mediated apoptosisLet-7Hepatocyte apoptosisNegative feedback loopMouse primary hepatocytesLet-7 miRNAsTGF-b signalingSignaling networksApoptosis of hepatocytesTransient transfectionFas expressionInhibiting hepatocyte apoptosisSiRNA knockdownLet-7 expressionLet-7 overexpressionMouse modelApoptosisPrimary hepatocytesSuppressed hepatocyte apoptosisTET3Liver fibrosisFeedback loopExpressionDriver of liver fibrosisAdeno-associated viral vectorsExpert consensus on the vitrification of human oocytes and embryos
Li D, Gao Y, Li R, Medicine C. Expert consensus on the vitrification of human oocytes and embryos. Chinese Medical Journal 2023, 136: 2773-2775. PMID: 37847199, PMCID: PMC10686607, DOI: 10.1097/cm9.0000000000002895.Peer-Reviewed Original ResearchAtorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A
Yin Z, You S, Zhang S, Zhang L, Wu B, Huang X, Lu S, Cao L, Zhang Y, Li D, Zhang X, Liu J, Sun Y, Zhang N. Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A. Biomedicine & Pharmacotherapy 2023, 166: 115228. PMID: 37557013, DOI: 10.1016/j.biopha.2023.115228.Peer-Reviewed Original ResearchConceptsMitochondrial pathway of apoptosisRegulate protein ubiquitinationPathway of apoptosisE3 ubiquitin ligaseVascular endothelial injuryDeath of vascular endothelial cellsEndothelial injuryMitochondrial pathwayUbiquitin ligaseWWP2 overexpressionProteasome pathwayProtein ubiquitinationBcl-2/BaxBiological processesWWP2Vascular endotheliumATP5ALipid-lowering drugsUbiquitinEffect of atorvastatinImproving vascular endothelial functionVascular endothelial functionDamaged vascular endotheliumVascular endothelial cellsMechanism of atorvastatinLive birth following an innovative artificial oocyte activation protocol using double calcium stimulators
Gao Y, Yang D, Fang Y, Wang X, Li D. Live birth following an innovative artificial oocyte activation protocol using double calcium stimulators. Chinese Medical Journal 2023, 136: 2101-2103. PMID: 36914951, PMCID: PMC10476707, DOI: 10.1097/cm9.0000000000002407.Peer-Reviewed Original Research