2024
Computational modeling of the physical features that influence breast cancer invasion into adipose tissue
Zheng Y, Wang D, Beeghly G, Fischbach C, Shattuck M, O'Hern C. Computational modeling of the physical features that influence breast cancer invasion into adipose tissue. APL Bioengineering 2024, 8: 036104. PMID: 38966325, PMCID: PMC11223776, DOI: 10.1063/5.0209019.Peer-Reviewed Original ResearchBreast cancer invasionCancer cellsMechanical propertiesCancer invasionDiscrete element method simulationsMechanical properties of cancer cellsProperties of cancer cellsElement method simulationsCancer cell invasionAdipose tissueDegree of invasionCohesive spherical particlesBiochemical signalsMethod simulationsCell invasionMaster curveSpherical particlesExtracellular matrixAdipocytesInfluence disease progressionSystem pressureDeformable polyhedronInvasionDe-mixingCells
2012
Constraints and vibrations in static packings of ellipsoidal particles
Schreck CF, Mailman M, Chakraborty B, O'Hern CS. Constraints and vibrations in static packings of ellipsoidal particles. Physical Review E 2012, 85: 061305. PMID: 23005084, DOI: 10.1103/physreve.85.061305.Peer-Reviewed Original ResearchConceptsStatic packingsEllipsoidal particlesFinite compressionMechanical propertiesStiffness matrixAspect ratioSpherical particlesHarmonic responseNumber of particlesAmorphous packingsParticlesAmplitude δPotential energy scalesMatrixInterparticle separationCompressionVibrationModePackingContact numberContactJamming