2024
Computational modeling of the physical features that influence breast cancer invasion into adipose tissue
Zheng Y, Wang D, Beeghly G, Fischbach C, Shattuck M, O'Hern C. Computational modeling of the physical features that influence breast cancer invasion into adipose tissue. APL Bioengineering 2024, 8: 036104. PMID: 38966325, PMCID: PMC11223776, DOI: 10.1063/5.0209019.Peer-Reviewed Original ResearchBreast cancer invasionCancer cellsMechanical propertiesCancer invasionDiscrete element method simulationsMechanical properties of cancer cellsProperties of cancer cellsElement method simulationsCancer cell invasionAdipose tissueDegree of invasionCohesive spherical particlesBiochemical signalsMethod simulationsCell invasionMaster curveSpherical particlesExtracellular matrixAdipocytesInfluence disease progressionSystem pressureDeformable polyhedronInvasionDe-mixingCellsMechanical plasticity of cell membranes enhances epithelial wound closure
Ton A, MacKeith A, Shattuck M, O'Hern C. Mechanical plasticity of cell membranes enhances epithelial wound closure. Physical Review Research 2024, 6: l012036. DOI: 10.1103/physrevresearch.6.l012036.Peer-Reviewed Original ResearchLarval wing discsWing discEmbryonic ectodermWing disc epitheliumCell membraneDeformable particlesDisc epitheliumElasto-plastic responseCell mechanicsPlastic deformationClosure behaviorDrosophilaCell morphologyDevelopmental stagesDP simulationsMechanical responseElastic responseEctodermLarvalMechanical plasticityCellsMembraneEpithelial wound closureEpithelial wound healingWound closure
2019
Organization of Embryonic Morphogenesis via Mechanical Information
Das D, Jülich D, Schwendinger-Schreck J, Guillon E, Lawton AK, Dray N, Emonet T, O'Hern CS, Shattuck MD, Holley SA. Organization of Embryonic Morphogenesis via Mechanical Information. Developmental Cell 2019, 49: 829-839.e5. PMID: 31178400, PMCID: PMC6590525, DOI: 10.1016/j.devcel.2019.05.014.Peer-Reviewed Original ResearchConceptsEmbryonic organizerCell motionCell polarityTransgenic perturbationsEmbryonic morphogenesisMorphogen signalingTail organizerZebrafish embryosCell movementMechanical informationCell adhesionCell contractilityNeighboring cellsLocal biochemicalEmbryosMorphogenesisSecondary consequenceAdditional mechanismCellsMorphogensTranscriptionSignalingSystematic analysisOrganizersComputational modeling