2020
Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation
Kang JW, Yan J, Ranjan K, Zhang X, Turner JR, Abraham C. Myeloid Cell Expression of LACC1 Is Required for Bacterial Clearance and Control of Intestinal Inflammation. Gastroenterology 2020, 159: 1051-1067. PMID: 32693188, PMCID: PMC8139320, DOI: 10.1053/j.gastro.2020.07.024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCells, CulturedCoculture TechniquesColitis, UlcerativeCytokinesDextran SulfateDisease Models, AnimalDNA-Binding ProteinsFemaleHost Microbial InteractionsHumansImmunity, MucosalIntestinal MucosaIntracellular Signaling Peptides and ProteinsMaleMiceMice, KnockoutMyeloid CellsPrimary Cell CultureSalmonella InfectionsSalmonella typhimuriumConceptsIntestinal lymphoid organsBurden of bacteriaDextran sodium sulfateWild-type miceLymphoid organsTh17 cytokinesIntestinal inflammationDendritic cellsMyeloid cellsT cellsTh2 cytokinesMesenteric lymph node dendritic cellsLymph node dendritic cellsMyeloid cell-derived cytokinesAdaptive T cell responsesT cell transfer colitisMyeloid-specific disruptionInflammatory bowel diseaseReactive oxygen speciesImmune-mediated diseasesT cell responsesT helper 1Cell-derived cytokinesT cell cytokinesBone marrow-derived macrophages
2015
T Cell–Extrinsic CD18 Attenuates Antigen-Dependent CD4+ T Cell Activation In Vivo
Wu X, Lahiri A, Sarin R, Abraham C. T Cell–Extrinsic CD18 Attenuates Antigen-Dependent CD4+ T Cell Activation In Vivo. The Journal Of Immunology 2015, 194: 4122-4129. PMID: 25801431, PMCID: PMC4404034, DOI: 10.4049/jimmunol.1401328.Peer-Reviewed Original ResearchConceptsT cell activationCell proliferationAg-dependent T cell activationCell activationCell-extrinsic roleHematopoietic cellsEssential roleT cell proliferationCritical roleAdhesion moleculesΒ2 integrinsProliferationT cellsCellsActivationVivoActivation profilesAPCNaive T cellsSecondary lymphoid organsLeukocyte adhesion moleculesTraffickingRoleIntegrinsCD11b blockade
2014
NOD2 Regulates CXCR3-Dependent CD8+ T Cell Accumulation in Intestinal Tissues with Acute Injury
Wu X, Lahiri A, Haines GK, Flavell RA, Abraham C. NOD2 Regulates CXCR3-Dependent CD8+ T Cell Accumulation in Intestinal Tissues with Acute Injury. The Journal Of Immunology 2014, 192: 3409-3418. PMID: 24591373, PMCID: PMC4064676, DOI: 10.4049/jimmunol.1302436.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBone Marrow CellsCD3 ComplexCD8-Positive T-LymphocytesCell MovementCells, CulturedChemokine CXCL10Chemokine CXCL9ColitisDendritic CellsFlow CytometryGene ExpressionInterferon-gammaInterleukin-10Intestinal MucosaIntestinesMacrophagesMiceMice, Inbred C57BLMice, KnockoutModels, ImmunologicalNod2 Signaling Adaptor ProteinReceptors, CXCR3Reverse Transcriptase Polymerase Chain ReactionConceptsT cell accumulationT cell migrationT cell activationT cellsIntestinal injuryIntestinal tissueCell accumulationCell activationSmall intestinal lamina propriaIFN-γ neutralizationIntestinal T cellsT-cell depletionIntestinal immune homeostasisIL-10 productionT cell recruitmentHuman autoimmune diseasesIntestinal lamina propriaTreatment of miceIL-10 expressionIntestinal stromal cellsT cell outcomesCell migrationCXCR3 blockadeMAb administrationDendritic cells
2011
Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses
Sarin R, Wu X, Abraham C. Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 9560-9565. PMID: 21606346, PMCID: PMC3111257, DOI: 10.1073/pnas.1017854108.Peer-Reviewed Original ResearchMeSH KeywordsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell ProliferationCells, CulturedFlow CytometryHEK293 CellsHeLa CellsHumansImmunoblottingInflammatory Bowel DiseasesInterferon-gammaInterleukin-17Interleukin-23InterleukinsLuciferasesPolymorphism, Single NucleotideReceptors, InterleukinSignal TransductionSTAT3 Transcription FactorTh17 CellsConceptsT cellsIL-22 productionIL-23 receptorT cell functional responsesMultiple inflammatory diseasesPrimary human CD4WT CD8Tc17 cellsIL-17Arginine alleleInflammatory diseasesReceptor polymorphismsPrimary CD4Transcription 3 (STAT3) activationCD8Human CD4Function alterationsSignificant protectionHuman genetic polymorphismsGenetic polymorphismsR381QCD4AutoimmunityFunctional consequencesSignal transducer