A Vitamin D3 Analog Induces a G1-Phase Arrest in CaCo-2 Cells by Inhibiting Cdk2 and Cdk6: Roles of Cyclin E, p21Waf1, and p27Kip1**This work was supported by National Institutes of Health Grants DK-39573, CA-36745 (to T.A.B. and M.B.) and P30DK42086 (to T.A.B., Digestive Disease Research Core Center).
Scaglione-Sewell B, Bissonnette M, Skarosi S, Abraham C, Brasitus T. A Vitamin D3 Analog Induces a G1-Phase Arrest in CaCo-2 Cells by Inhibiting Cdk2 and Cdk6: Roles of Cyclin E, p21Waf1, and p27Kip1**This work was supported by National Institutes of Health Grants DK-39573, CA-36745 (to T.A.B. and M.B.) and P30DK42086 (to T.A.B., Digestive Disease Research Core Center). Endocrinology 2000, 141: 3931-3939. DOI: 10.1210/en.141.11.3931.Peer-Reviewed Original ResearchF6-D3Caco-2 cellsActivity of cyclin-dependent kinase 2Azoxymethane model of colon cancerCaco-2Colon cancerModel of colon cancerCyclin EChemopreventive actionTransforming growth factor-bCyclin-dependent kinase 2Human colon adenocarcinoma cell lineAntibody neutralization studiesColon adenocarcinoma cell lineDevelopment of colon adenocarcinomaVitamin D3 analogsHuman colonic epitheliumHuman colon cancerCyclin-dependent kinasesGrowth factor BRats treated with azoxymethaneExpression of cyclin EAdenocarcinoma cell lineAzoxymethane modelCell cycle arrest