2021
Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Raffini LJ, Hanson SJ, Cholette JM, Pinto MG, Li S, Kandil SB, Nellis ME, Shabanova V, Silva CT, Tala JA, McPartland T, Spinella PC. Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2021, 49: e369-e380. PMID: 33566465, PMCID: PMC7979442, DOI: 10.1097/ccm.0000000000004848.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisCentral venous cathetersEfficacy of prophylaxisDeep venous thrombosisAge-dependent heterogeneityAnti-Xa levelsVenous cathetersVenous thrombosisFactor VIII activityThrombin generationPlatelet countClinical trialsIll childrenPhase 2bVIII activityLow factor VIII activityCatheter-Associated ThrombosisInternational units/mLMinimum platelet countOlder childrenCritically Ill ChildrenEndogenous thrombin potentialHigher platelet countsPost Hoc Analysis
2020
Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Shabanova V, Raffini LJ, Kandil SB, Li S, Pinto MG, Cholette JM, Hanson SJ, Nellis ME, Silva CT, Chima R, Sharathkumar A, Thomas KA, McPartland T, Tala JA, Spinella PC. Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2020, 49: e235-e246. PMID: 33372745, PMCID: PMC7902342, DOI: 10.1097/ccm.0000000000004784.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisDeep venous thrombosisUsual care armCentral venous cathetersVenous thrombosisClinical trialsEnoxaparin armCare armVenous cathetersEarly prophylaxisIll childrenThrombin generationPhase 2bCatheter-Associated ThrombosisInternational units/mLAnti-Xa levelsCritically Ill ChildrenRandomized clinical trialsEndogenous thrombin potentialRelevant bleedingUsual careTrial armsRisk ratioThrombin potential
2015
Diagnostic accuracy of point-of-care ultrasound for catheter-related thrombosis in children
Li S, Silva CT, Brudnicki AR, Baker KE, Tala JA, Pinto MG, Polikoff LA, Qin L, Faustino EV, Northeast Pediatric Critical Care Research Consortium. Diagnostic accuracy of point-of-care ultrasound for catheter-related thrombosis in children. Pediatric Radiology 2015, 46: 219-228. PMID: 26440129, PMCID: PMC4738063, DOI: 10.1007/s00247-015-3467-9.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionCausalityCentral Venous CathetersChildChild, PreschoolCohort StudiesConnecticutFemaleHumansInfantInfant, NewbornMalePoint-of-Care TestingPrevalenceReproducibility of ResultsRisk FactorsSensitivity and SpecificitySex DistributionUltrasonographyUpper Extremity Deep Vein ThrombosisConceptsCatheter-related thrombosisCare ultrasoundChance-corrected agreementIll childrenCare USCentral venous catheter-related thrombosisPediatric radiologistsDeep venous thrombosisCentral venous cathetersIntensive care unitVenous cathetersVenous thrombosisCare unitSubclavian veinThrombosisAccuracy of pointCatheterSensitivity of pointDiscordant readingsDiagnostic accuracyMulticenterUltrasoundRadiology departmentChildrenPhysiciansFactor VIII May Predict Catheter-Related Thrombosis in Critically Ill Children
Faustino EV, Li S, Silva CT, Pinto MG, Qin L, Tala JA, Rinder HM, Kupfer GM, Shapiro ED. Factor VIII May Predict Catheter-Related Thrombosis in Critically Ill Children. Pediatric Critical Care Medicine 2015, 16: 497-504. PMID: 25828784, PMCID: PMC4497863, DOI: 10.1097/pcc.0000000000000409.Peer-Reviewed Original ResearchConceptsCatheter-related thrombosisFactor VIII activityIncident thrombosisIll childrenVIII activityCentral venous catheter-related thrombosisDays of enrollmentProspective cohort studyCentral venous cathetersImportant clinical predictorsTertiary academic centerIU/dlPharmacologic thromboprophylaxisSurveillance ultrasonographyCohort studyVenous cathetersClinical predictorsThrombotic eventsOdds ratioSD increaseHigh riskThrombosisAcademic centersFactor VIIIYouden index
2014
Blood glucose as a marker of venous thromboembolism in critically ill children
Tala JA, Silva CT, Pemira S, Vidal E, Faustino EV. Blood glucose as a marker of venous thromboembolism in critically ill children. Journal Of Thrombosis And Haemostasis 2014, 12: 891-896. PMID: 24708410, PMCID: PMC4055532, DOI: 10.1111/jth.12583.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsBiomarkersBlood GlucoseChildChild, PreschoolChi-Square DistributionCritical IllnessFemaleHumansHyperglycemiaInfantIntensive Care Units, PediatricLogistic ModelsMaleOdds RatioPredictive Value of TestsPrognosisRetrospective StudiesRisk FactorsTime FactorsVenous ThromboembolismConceptsMaximum blood glucoseVenous thromboembolismBlood glucoseIll childrenOdds ratioPediatric intensive care unitRetrospective cohort studyCentral venous cathetersNon-diabetic childrenSeverity of illnessIntensive care unitLogistic regression modelsCohort studyVenous cathetersAntithrombotic useDiabetes mellitusPrimary outcomeCare unitHyperglycemic subjectsPrior diagnosisThromboembolismHyperglycemiaMechanical ventilatorPotential predictorsSubject characteristics
2012
Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children
Faustino EV, Spinella PC, Li S, Pinto MG, Stoltz P, Tala J, Card ME, Northrup V, Baker KE, Goodman TR, Chen L, Silva CT. Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children. The Journal Of Pediatrics 2012, 162: 387-391. PMID: 22883418, PMCID: PMC3575007, DOI: 10.1016/j.jpeds.2012.06.059.Peer-Reviewed Original ResearchConceptsCVC-related deep venous thrombosisDeep venous thrombosisCentral venous cathetersIntensive care unitAcute complicationsIll childrenVenous cathetersVenous thrombosisCare unitPediatric intensive care unitProspective cohort studyChronic complicationsHospital lengthCohort studyPatient demographicsPulmonary embolismCompression ultrasonographyMechanical ventilationHigher oddsCurrent incidenceColor DopplerComplicationsCVC characteristicsLarger studyThrombosis