2021
EXERT: Impact of COVID‐19 on retention and intervention delivery of a large multisite exercise trial in adults with MCI
Baker L, Cotman C, Morrison R, Katula J, Chmelo E, Hodge H, Johnson C, Kipperman S, Matthews G, Bennett D, Mason J, LaCroix A, van Dyck C, Okonkwo O, Tam S, Fairchild J, Li C, Welsh‐Bohmer K, Feldman H, Group T. EXERT: Impact of COVID‐19 on retention and intervention delivery of a large multisite exercise trial in adults with MCI. Alzheimer's & Dementia 2021, 17: e056518. PMCID: PMC9011773, DOI: 10.1002/alz.056518.Peer-Reviewed Original ResearchIntervention deliveryExercise trialsSelf-reported adherence dataCOVID-19 pandemicCOVID-19 incidence ratesAdherence ratesMajority of participantsAerobic exerciseMonth 13Exercise sessionsIncidence rateAD biomarkersSedentary adultsAdherence dataAerobic groupWeekly callsRecruitment goalsInfection rateAddress barriersCOVID infection ratesOlder adultsGlobal health crisisWeeksMCICOVID-19
2018
Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial
Barcelos NM, Van Ness PH, Wagner AF, MacAvoy MG, Mecca AP, Anderson GM, Trentalange M, Hawkins KA, Sano M, Arnsten AFT, van Dyck CH. Guanfacine treatment for prefrontal cognitive dysfunction in older participants: a randomized clinical trial. Neurobiology Of Aging 2018, 70: 117-124. PMID: 30007160, PMCID: PMC6503670, DOI: 10.1016/j.neurobiolaging.2018.05.033.Peer-Reviewed Original ResearchConceptsDose of guanfacineQuality of lifeZ-scoreCognitive functionPrefrontal cognitive dysfunctionCommon adverse eventsPrimary outcome measureRandomized clinical trialsGlobal functionOlder participantsHealthy older participantsPrefrontal cognitive functionDry mouthAdverse eventsAgonist guanfacineClinical trialsGuanfacine treatmentCognitive dysfunctionMean changeOutcome measuresPlaceboGuanfacineOlder individualsWeeksDose
1992
Peptide T Treatment of Cognitive Impairment in HIV‐Positive Intravenous Drug Users
Rosen M, Bridge T, O'Malley S, Pearsall H, Martini B, O'Connor P, Brett‐Smith H, Thomas H, Van Dyck C, Woods S, Kosten T. Peptide T Treatment of Cognitive Impairment in HIV‐Positive Intravenous Drug Users. American Journal On Addictions 1992, 1: 332-338. DOI: 10.1111/j.1521-0391.1992.tb00359.x.Peer-Reviewed Original ResearchHIV-positive intravenous drug usersDouble-blind crossover studyPeptide T treatmentHIV-positive patientsPeptide TOpen clinical trialIntravenous drug usersVasoactive intestinal peptideAIDS dementiaCrossover studyNeuropsychological improvementAZT treatmentIntestinal peptideClinical trialsDrug usersCognitive impairmentPatientsNeuropsychological functionCognitive functionT treatmentPlaceboThree timesWeeksPotential utilityTreatment