2021
OpenSAFELY NHS Service Restoration Observatory 1: primary care clinical activity in England during the first wave of COVID-19
Curtis HJ, MacKenna B, Croker R, Inglesby P, Walker AJ, Morley J, Mehrkar A, Morton CE, Bacon S, Hickman G, Bates C, Evans D, Ward T, Cockburn J, Davy S, Bhaskaran K, Schultze A, Rentsch CT, Williamson EJ, Hulme WJ, McDonald HI, Tomlinson L, Mathur R, Drysdale H, Eggo RM, Wing K, Wong AY, Forbes H, Parry J, Hester F, Harper S, Evans SJ, Douglas IJ, Smeeth L, Goldacre B, . OpenSAFELY NHS Service Restoration Observatory 1: primary care clinical activity in England during the first wave of COVID-19. British Journal Of General Practice 2021, 72: bjgp.2021.0380. PMID: 34750105, PMCID: PMC8589464, DOI: 10.3399/bjgp.2021.0380.Peer-Reviewed Original ResearchConceptsClinical activityGeneral practicePre-pandemic levelsNormal levelsPrimary care dataHealthcare activitiesAsthma reviewCohort studyRespiratory symptomsRespiratory infectionsDisease reviewDiseases codesRespiratory diseaseLaboratory testsNHS EnglandPatient recordsCare dataSustained dropCOVD-19 pandemicCOVID-19COVID-19 pandemicMost laboratory testsBroader recoverySmall reductionPandemicSocial determinants of pertussis and influenza vaccine uptake in pregnancy: a national cohort study in England using electronic health records
Walker JL, Rentsch CT, McDonald HI, Bak J, Minassian C, Amirthalingam G, Edelstein M, Thomas S. Social determinants of pertussis and influenza vaccine uptake in pregnancy: a national cohort study in England using electronic health records. BMJ Open 2021, 11: e046545. PMID: 34155074, PMCID: PMC8217954, DOI: 10.1136/bmjopen-2020-046545.Peer-Reviewed Original ResearchConceptsPertussis vaccine uptakeVaccine uptakeNon-white ethnicityPregnant womenEligible pregnanciesSocial determinantsCohort studyNationwide population-based cohort studyClinical Practice Research DatalinkPopulation-based cohort studyGreater deprivationCare dataLow vaccine uptakeInfluenza vaccine uptakeSecondary care dataNational cohort studyPrimary care dataVaccine-preventable diseasesLow uptakeVaccine promotion strategiesElectronic health recordsInfluenza vaccinationMaternal ageSuccessive pregnanciesVaccination promotionFactors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform
Bhaskaran K, Bacon S, Evans SJ, Bates CJ, Rentsch CT, MacKenna B, Tomlinson L, Walker AJ, Schultze A, Morton CE, Grint D, Mehrkar A, Eggo RM, Inglesby P, Douglas IJ, McDonald HI, Cockburn J, Williamson EJ, Evans D, Curtis HJ, Hulme WJ, Parry J, Hester F, Harper S, Spiegelhalter D, Smeeth L, Goldacre B. Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform. The Lancet Regional Health - Europe 2021, 6: 100109. PMID: 33997835, PMCID: PMC8106239, DOI: 10.1016/j.lanepe.2021.100109.Peer-Reviewed Original ResearchNon-COVID deathsCOVID-19 deathsNational death registrationsPrimary care dataOpenSAFELY platformCOVID-19Health Research Oxford Biomedical Research CentrePopulation-based cohort analysisDeath registrationUK primary care dataCare dataPre-existing medical conditionsCOVID-19 mortality riskChronic liver diseaseHistory of cancerUK Medical Research CouncilHealth Data Research UKNational InstituteCOVID-19 mortalityMagnitude of associationMedical Research CouncilNon-white ethnic groupsBiomedical Research CentreCohort studyLiver disease
2020
HIV infection and COVID-19 death: a population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform
Bhaskaran K, Rentsch CT, MacKenna B, Schultze A, Mehrkar A, Bates CJ, Eggo RM, Morton CE, Bacon SCJ, Inglesby P, Douglas IJ, Walker AJ, McDonald HI, Cockburn J, Williamson EJ, Evans D, Forbes HJ, Curtis HJ, Hulme WJ, Parry J, Hester F, Harper S, Evans SJW, Smeeth L, Goldacre B. HIV infection and COVID-19 death: a population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform. The Lancet HIV 2020, 8: e24-e32. PMID: 33316211, PMCID: PMC7773630, DOI: 10.1016/s2352-3018(20)30305-2.Peer-Reviewed Original ResearchConceptsCOVID-19 deathsNational death registrationsPrimary care dataHazard ratioHIV infectionOpenSAFELY platformBlack ethnicityHealth Research Oxford Biomedical Research CentreElectronic primary care dataPopulation-based cohort analysisDeath registrationUK primary care dataCare dataLarge-scale population-based studyRetrospective cohort studyPrimary care recordsUK Medical Research CouncilPopulation-based studyRisk of deathHealth Data Research UKNon-black individualsNational InstituteCOVID-19 mortalityMedical Research CouncilBiomedical Research Centre