2022
Overnight Abstinence Is Associated With Smaller Secondary Somatosensory Cortical Volumes and Higher Somatosensory-Motor Cortical Functional Connectivity in Cigarette Smokers
Chen Y, Dhingra I, Chaudhary S, Fucito L, Li CR. Overnight Abstinence Is Associated With Smaller Secondary Somatosensory Cortical Volumes and Higher Somatosensory-Motor Cortical Functional Connectivity in Cigarette Smokers. Nicotine & Tobacco Research 2022, 24: 1889-1897. PMID: 35796689, PMCID: PMC9653081, DOI: 10.1093/ntr/ntac168.Peer-Reviewed Original ResearchMeSH KeywordsHumansMagnetic Resonance ImagingNicotineSmokersSomatosensory CortexSubstance Withdrawal SyndromeTobacco ProductsConceptsResting-state functional connectivityGray matter volumeWithdrawal symptom severityOvernight abstinenceFunctional connectivityRight SIISymptom severityCigarette smokersSomatosensory cortexMatter volumeRight secondary somatosensory cortexSmaller gray matter volumeSubcortical gray matter volumesSecond somatosensory cortexSecondary somatosensory cortexCortical functional connectivityMotor impulsivityVoxel-wise morphometryRegional gray matter volumeLeft ventral hippocampusGMV alterationsCigarette smokingSatiety stateAbstinence symptomsHigher-order sensory cortices
2020
Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction
Zhang S, Zhornitsky S, Wang W, Le TM, Dhingra I, Chen Y, Li C. Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction. Addiction Biology 2020, 26: e12989. PMID: 33300238, PMCID: PMC8614224, DOI: 10.1111/adb.12989.Peer-Reviewed Original ResearchConceptsPeriaqueductal grayPain circuitsDrug useCocaine addictionFunctional connectivityPrefrontal cortical connectivityState functional connectivityReward circuit dysfunctionRecent cocaine useHealthy control participantsInferior parietal cortexCompulsive drug useHabitual drug useCircuit dysfunctionCocaine withdrawalCocaine-dependent individualsCocaine cravingCortical connectivitySignificant anxietyDorsomedial prefrontalParietal cortexCocaine useIntrinsic connectivitySubcortical hubsDrug seekingCue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving
Zhang S, Zhornitsky S, Wang W, Dhingra I, Le TM, Li CR. Cue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving. Drug And Alcohol Dependence 2020, 216: 108240. PMID: 32853997, PMCID: PMC7606798, DOI: 10.1016/j.drugalcdep.2020.108240.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyCocaineCocaine-Related DisordersCravingCuesFemaleHumansMagnetic Resonance ImagingMalePeriaqueductal GrayPrefrontal CortexRewardSubstance Withdrawal SyndromeYoung AdultConceptsPeriaqueductal grayPain circuitsHabitual drug useCocaine withdrawalCocaine cravingDrug useCue exposureNeutral cue exposureReward circuit dysfunctionCocaine Craving QuestionnaireCocaine cue exposureChronic cocaine useSex differencesCocaine-dependent participantsCircuit dysfunctionFemale CDVentromedial prefrontal cortexCocaine useCocaine addictionFunctional connectivityPrefrontal cortexDependent participantsWithdrawalHigher activationCocaine
2013
Neural Bases of Pharmacological Treatment of Nicotine Dependence - Insights from Functional Brain Imaging: A Systematic Review
Menossi HS, Goudriaan AE, de Azevedo-Marques Périco C, Nicastri S, de Andrade AG, D’Elia G, Li CS, Castaldelli-Maia JM. Neural Bases of Pharmacological Treatment of Nicotine Dependence - Insights from Functional Brain Imaging: A Systematic Review. CNS Drugs 2013, 27: 921-941. PMID: 23853032, DOI: 10.1007/s40263-013-0092-8.Peer-Reviewed Original ResearchMeSH KeywordsBrainDrug DiscoveryHumansMagnetic Resonance ImagingRandomized Controlled Trials as TopicSmoking CessationSubstance Withdrawal SyndromeTobacco Use DisorderConceptsPharmacological treatmentNicotine dependenceContinuous arterial spin labelingCingulate cortexPharmacological smoking cessation treatmentsBlood oxygen level-dependent imagingNicotine replacement therapyPositron emission tomography studySmoking cessation treatmentEffects of vareniclineMaintenance of smokingLevel-dependent imagingNicotine-dependent individualsEmission tomography studiesMore effective treatmentsFunctional magnetic resonance imagingMagnetic resonance imagingPosterior cingulate cortexArterial spin labelingWeb of ScienceLateral orbitofrontal cortexSynthesis MethodsTwoClinical characteristicsData sourcesWeNicotine replacement
2010
Increased error-related thalamic activity during early compared to late cocaine abstinence
Li CS, Luo X, Sinha R, Rounsaville BJ, Carroll KM, Malison RT, Ding YS, Zhang S, Ide JS. Increased error-related thalamic activity during early compared to late cocaine abstinence. Drug And Alcohol Dependence 2010, 109: 181-189. PMID: 20163923, PMCID: PMC2875333, DOI: 10.1016/j.drugalcdep.2010.01.008.Peer-Reviewed Original Research
2007
Imaging stress‐ and cue‐induced drug and alcohol craving: association with relapse and clinical implications
SINHA R, LI C. Imaging stress‐ and cue‐induced drug and alcohol craving: association with relapse and clinical implications. Drug And Alcohol Review 2007, 26: 25-31. PMID: 17364833, DOI: 10.1080/09595230601036960.Peer-Reviewed Original ResearchConceptsRelapse outcomesDrug-related cuesPosterior insula regionsCue-induced cravingDrug cue exposureCue-induced drugBrain imaging studiesDrug cuesNeural correlatesCorticostriatal-limbic circuitryCue exposureInsula regionsBrain correlatesRelapse propensityMedial prefrontalBehavioral treatmentAddictive disordersAlcohol cravingPosterior cingulateNeural activityBrain regionsArousal responseLimbic circuitryNeural circuitsCraving