2006
Alexithymia and stress-induced brain activation in cocaine-dependent men and women.
Li CS, Sinha R. Alexithymia and stress-induced brain activation in cocaine-dependent men and women. Journal Of Psychiatry And Neuroscience 2006, 31: 115-21. PMID: 16575427, PMCID: PMC1413961.Peer-Reviewed Original ResearchConceptsToronto Alexithymia ScaleFrontal cortexTAS scoresScript-guided imageryAbstinent cocaine-dependent subjectsBilateral temporal cortexFunctional magnetic resonanceStress-induced brain activationProcessing of stressMiddle frontal cortexCocaine-dependent individualsRight frontal cortexCocaine-dependent menCocaine-dependent patientsNeutral imageryNeural processingBrain activationMale cocaine usersStressful situationsCocaine-dependent subjectsRight amygdalaAlexithymic featuresAlexithymia ScaleTemporal cortexSubcortical activation
2005
Neuroimaging study of sex differences in the neuropathology of cocaine abuse
Li CS, Kemp K, Milivojevic V, Sinha R. Neuroimaging study of sex differences in the neuropathology of cocaine abuse. Gender Medicine 2005, 2: 174-182. PMID: 16290890, DOI: 10.1016/s1550-8579(05)80046-4.Peer-Reviewed Original ResearchConceptsRegional brain activationBrain activationGreater activationBrain regionsSex differencesScript-guided imagerySubstance abusersCerebral perfusion deficitsBlood oxygenation level-dependent (BOLD) signalSame statistical thresholdCocaine-dependent menCue-induced cravingSuperior frontal gyrusLevel-dependent signalChronic cocaine useMale substance abusersSex-related factorsCocaine use disorderImportant sex differencesLeft uncusStress trialsClinical outcomesPerfusion deficitsRight claustrumPharmacologic challengeSex differences in brain activation during stress imagery in abstinent cocaine users: A functional magnetic resonance imaging study
Li CS, Kosten TR, Sinha R. Sex differences in brain activation during stress imagery in abstinent cocaine users: A functional magnetic resonance imaging study. Biological Psychiatry 2005, 57: 487-494. PMID: 15737663, DOI: 10.1016/j.biopsych.2004.11.048.Peer-Reviewed Original ResearchConceptsAbstinent cocaine usersStress imageryBrain activationAnterior cingulateCingulate cortexFunctional magnetic resonance imaging sessionFunctional magnetic resonance imaging studyMagnetic resonance imaging sessionScript-guided imageryInferior frontal cortexStress-induced cocaineCocaine usersPosterior cingulate cortexRight posterior cingulate cortexSex differencesMagnetic resonance imaging studyImagery vividnessResonance imaging studyFrontolimbic activityImagery periodMore activationDrug seekingFunctional neuroimagingCoping strategiesCocaine-dependent subjects