2024
Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches
Yang B, Xiang B, Wang T, Ma S, Li C. Neurogenetic underpinnings of nicotine use severity: Integrating the brain transcriptomes and GWAS variants via network approaches. Psychiatry Research 2024, 334: 115815. PMID: 38422867, PMCID: PMC11017751, DOI: 10.1016/j.psychres.2024.115815.Peer-Reviewed Original ResearchConceptsMediodorsal nucleus of the thalamusMedial prefrontal cortexPrefrontal cortexNeurogenetic underpinningsDorsolateral prefrontal cortexBrain transcriptomeDrug memoryOrbitofrontal cortexInhibitory controlSmoking severityAssociated with CPDHuman brain transcriptomeMediodorsal nucleusWhole-brainNeurogenetic mechanismsPrimary motor cortexMechanisms of individual variationCortexHub proteinsGenetic riskAmygdalaStriatumMotor cortexOPFCHippocampus
2021
Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task
Zhornitsky S, Dhingra I, Le TM, Wang W, Li CR, Zhang S. Reward-Related Responses and Tonic Craving in Cocaine Addiction: An Imaging Study of the Monetary Incentive Delay Task. The International Journal Of Neuropsychopharmacology 2021, 24: 634-644. PMID: 33822080, PMCID: PMC8378081, DOI: 10.1093/ijnp/pyab016.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsCocaine Craving QuestionnaireCCQ scoresRecent cocaine useHealthy controlsMonetary incentive delay taskReward-related responsesCocaine useVentral striatumIncentive delay taskMotor cortexReward responsesPrecentral gyrusCocaine addictionPrimary motor cortexSupplementary motor areaDelay taskIntense drug cravingFunctional magnetic resonance imagingMagnetic resonance imagingDrug-seeking behaviorHigher activationReward-related activityMotor areaWhole brain
2019
The effects of age on reward magnitude processing in the monetary incentive delay task
Dhingra I, Zhang S, Zhornitsky S, Le T, Wang W, Chao HH, Levy I, Li CR. The effects of age on reward magnitude processing in the monetary incentive delay task. NeuroImage 2019, 207: 116368. PMID: 31743790, PMCID: PMC7463276, DOI: 10.1016/j.neuroimage.2019.116368.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskIncentive delay taskSupplementary motor areaMagnitude of rewardAge-related differencesDelay taskRT differencesRegional activationAge effectsEffect of ageReaction time differencesRight anterior insulaMiddle frontal gyrusReward-directed behaviorExplicit cuesMagnitude processingBrain activationRight caudate headAnterior insulaFrontal gyrusReward magnitudeLarge rewardPrimary motor cortexCerebral processesParahippocampal gyrus
2017
Functional Connectivity Parcellation of the Human Thalamus by Independent Component Analysis
Zhang S, Li CR. Functional Connectivity Parcellation of the Human Thalamus by Independent Component Analysis. Brain Connectivity 2017, 7: 602-616. PMID: 28954523, PMCID: PMC5695755, DOI: 10.1089/brain.2017.0500.Peer-Reviewed Original ResearchConceptsWhole-brain connectivityThalamic connectivityFunctional connectivityState functional magnetic resonanceTime coursePrimary motor cortexWhole-brain functional connectivitySeed region analysisBrain functional connectivityFunctional magnetic resonanceIndependent component time coursesMotor cortexThalamic subdivisionsHuman thalamusCaudate nucleusThalamic clustersThalamusSubcortical regionsBrain regionsRegional functionPatterns of connectivityAffective functionsFunctional organizationMagnetic resonanceFunctional clusters
2014
The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults
Farr OM, Zhang S, Hu S, Matuskey D, Abdelghany O, Malison RT, Li CS. The effects of methylphenidate on resting-state striatal, thalamic and global functional connectivity in healthy adults. The International Journal Of Neuropsychopharmacology 2014, 17: 1177-1191. PMID: 24825078, PMCID: PMC4506752, DOI: 10.1017/s1461145714000674.Peer-Reviewed Original ResearchConceptsEffects of methylphenidateResting-state connectivityFunctional connectivityResting-state functional connectivityFrontal executive areasRegional brain activationAmygdala/hippocampusPrefrontal cortical connectivityDorsal striatumHealthy adultsCognitive performanceBrain activationExecutive areasGlobal functional connectivityCatecholaminergic signalingMotor cortexBrain regionsBrain functionPrimary motor cortexCortical connectivityCerebral connectivityMemory circuitsCatecholaminergic dysfunctionMethylphenidatePsychiatric disordersThe Effects of Methylphenidate on Cerebral Activations to Salient Stimuli in Healthy Adults
Farr OM, Hu S, Matuskey D, Zhang S, Abdelghany O, Li CS. The Effects of Methylphenidate on Cerebral Activations to Salient Stimuli in Healthy Adults. Experimental And Clinical Psychopharmacology 2014, 22: 154-165. PMID: 24188171, PMCID: PMC4105943, DOI: 10.1037/a0034465.Peer-Reviewed Original ResearchConceptsStop-signal taskSalient stimuliSaliency processingFunctional MRIAttention deficit hyperactivity disorderRight inferior parietal cortexHigh motivational valueDeficit hyperactivity disorderEffects of methylphenidateInferior parietal cortexHealthy adultsNeural basisCognitive functioningMotivational valueAttention disordersHyperactivity disorderBilateral caudate headCatecholaminergic signalingMethylphenidate groupParietal cortexCerebral activationHigher activationCatecholaminergic treatmentPrimary motor cortexCerebral activity
2013
Effects of Androgen Deprivation on Cerebral Morphometry in Prostate Cancer Patients – An Exploratory Study
Chao HH, Hu S, Ide JS, Uchio E, Zhang S, Rose M, Concato J, Li CS. Effects of Androgen Deprivation on Cerebral Morphometry in Prostate Cancer Patients – An Exploratory Study. PLOS ONE 2013, 8: e72032. PMID: 23977199, PMCID: PMC3747074, DOI: 10.1371/journal.pone.0072032.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyProstate cancer patientsGray matter volumeMagnetic resonance imagingPrimary motor cortexCancer patientsVoxel-based morphometryMatter volumeMotor cortexProstate cancerEffects of ADTLow-risk prostate cancerCerebral gray matter volumeStatistical Parametric Mapping 8Utility of brainControl participantsHigh-resolution magnetic resonance imagingPotential side effectsQuality of lifeResolution magnetic resonance imagingSame time pointsFunctional magnetic resonance imagingHigh-resolution T1Prefrontal cortical activationDorsolateral prefrontal cortex
2011
Neural processes of preparatory control for stop signal inhibition
Hu S, Li C. Neural processes of preparatory control for stop signal inhibition. Human Brain Mapping 2011, 33: 2785-2796. PMID: 21976392, PMCID: PMC3293936, DOI: 10.1002/hbm.21399.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeFunctional magnetic resonance imagingMotor inhibitionShorter stop-signal reaction timesPrefrontal cortexRight orbital frontal cortexMotor executionPrimary motor cortexOrbital frontal cortexSignal inhibitionMagnetic resonance imagingPosterior cingulate cortexInferior parietal lobuleRight prefrontal cortexMotor cortexSignal reaction timeBilateral putamenFrontal cortexHealthy adultsVentromedial prefrontal cortexCingulate cortexResonance imagingPreparatory inhibitionParietal lobuleStop-signal trials
2009
Functional Connectivity Delineates Distinct Roles of the Inferior Frontal Cortex and Presupplementary Motor Area in Stop Signal Inhibition
Duann JR, Ide JS, Luo X, Li CS. Functional Connectivity Delineates Distinct Roles of the Inferior Frontal Cortex and Presupplementary Motor Area in Stop Signal Inhibition. Journal Of Neuroscience 2009, 29: 10171-10179. PMID: 19675251, PMCID: PMC2769086, DOI: 10.1523/jneurosci.1300-09.2009.Peer-Reviewed Original ResearchConceptsMotor response inhibitionBasal ganglia circuitryPresupplementary motor areaInferior prefrontal cortexStop-signal inhibitionMotor areaRight inferior prefrontal cortexPrefrontal cortexResponse inhibitionSignal inhibitionRecent imaging literaturePrimary motor cortexMedial prefrontal cortexInferior frontal cortexMotor cortexFrontal cortexCortical areasPrimary siteVentral attention systemPreSMAGreater effective connectivityCortexFunctional interconnectivityPsychophysiological interactionGo trials