2024
Ligand‐gated ion channels as potential biomarkers for ADT‐mediated cognitive decline in prostate cancer patients
Verma S, Singh V, Nagampalli V, Ponsky L, Li C, Chao H, Gupta S. Ligand‐gated ion channels as potential biomarkers for ADT‐mediated cognitive decline in prostate cancer patients. Molecular Carcinogenesis 2024, 63: 1051-1063. PMID: 38482990, PMCID: PMC11096008, DOI: 10.1002/mc.23708.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyN-methyl-D-aspartate receptorsGamma-aminobutyric acidLigand-gated ion channelsType 1 angiotensin II receptorGlial cellsAndrogen signaling inhibitorsProstate cancer cell culture modelHigher risk of cognitive dysfunctionProstate cancer patientsPotential biomarkersBrain-derived neurotrophic factorCognitive dysfunctionIon channelsProtein-protein interaction network analysisAngiotensin II receptorsNuclear receptor subfamily 3 group C member 1Real-time polymerase chain reaction assayBrain glial cellsCytokine-cytokine receptor interactionCancer cell culture modelsAnalysis of genesGene-disease associationsInteraction network analysisPolymerase chain reaction assay
2020
Predicting alcohol dependence from multi‐site brain structural measures
Hahn S, Mackey S, Cousijn J, Foxe JJ, Heinz A, Hester R, Hutchinson K, Kiefer F, Korucuoglu O, Lett T, Li C, London E, Lorenzetti V, Maartje L, Momenan R, Orr C, Paulus M, Schmaal L, Sinha R, Sjoerds Z, Stein DJ, Stein E, van Holst R, Veltman D, Walter H, Wiers RW, Yucel M, Thompson PM, Conrod P, Allgaier N, Garavan H. Predicting alcohol dependence from multi‐site brain structural measures. Human Brain Mapping 2020, 43: 555-565. PMID: 33064342, PMCID: PMC8675424, DOI: 10.1002/hbm.25248.Peer-Reviewed Original ResearchConceptsAlcohol dependenceRight lateral orbitofrontal cortexLeft superior frontal gyrusCurrent alcohol dependenceTransverse temporal gyrusENIGMA Addiction Working GroupInclusion of casesSuperior frontal gyrusStructural magnetic resonanceCortical surface areaRight transverse temporal gyrusLateral orbitofrontal cortexBrain structural measuresCortical thicknessPutamen volumePotential biomarkers
2016
Craving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum
Zhang J, Ma S, Li C, Liu L, Xia C, Lan J, Wang L, Liu B, Yao Y, Fang X. Craving behavioral intervention for internet gaming disorder: remediation of functional connectivity of the ventral striatum. Addiction Biology 2016, 23: 337-346. PMID: 27894158, PMCID: PMC5446940, DOI: 10.1111/adb.12474.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPsychobehavioral interventionsIGD subjectsFunctional connectivityHealthy controlsInternet gaming disorderGreater resting-state functional connectivityFrontal gyrusEffects of CBICross-sectional studyBehavioral intervention studyDirect current stimulationInferior parietal lobuleMiddle frontal gyrusGaming disorderSeverity of IGDInferior frontal gyrusSimilar time intervalsEffective treatmentIntervention studiesNon-invasive techniquePotential biomarkersVentral striatumParietal lobuleCurrent stimulation