2024
The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking
Le T, Oba T, Couch L, McInerney L, Li C. The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking. ENeuro 2024, 11: eneuro.0437-23.2024. PMID: 38365840, PMCID: PMC10901196, DOI: 10.1523/eneuro.0437-23.2024.Peer-Reviewed Original ResearchConceptsSuperior frontal gyrusReward-seekingCingulate cortexNeural correlatesPain avoidanceAction biasDorsal anterior cingulate cortexLeft posterior cingulate cortexAction-outcome associationsGo/No-Go taskAnterior cingulate cortexPosterior cingulate cortexImpact of outcomesHigher learning rateReward trialsFrontal gyrusAvoidance learningMidcingulate cortexNeural substratesAssociative learningAction tendenciesPre-SMAAssociated with activationPrecentral gyrusPostcentral gyrus
2022
Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task
Chen Y, Chaudhary S, Li C. Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task. NeuroImage 2022, 264: 119764. PMID: 36427755, PMCID: PMC9837714, DOI: 10.1016/j.neuroimage.2022.119764.Peer-Reviewed Original ResearchConceptsSupplementary motor areaMonetary incentive delay taskMedial orbitofrontal cortexBilateral anterior insulaLoss outcomesAnterior insulaLoss anticipationIncentive delay taskBilateral striatumPrecentral gyrusCingulate cortexBilateral medial orbitofrontal cortexDorsal anterior cingulate cortexRight occipital cortexDelay taskAnterior cingulate cortexPosterior cingulate cortexNeural correlatesActivation likelihood estimationRight thalamusMotor areaOccipital cortexRegional activityDistinct neural activityStriatum
2021
Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis
Zhornitsky S, Chaudhary S, Le TM, Chen Y, Zhang S, Potvin S, Chao HH, van Dyck CH, Li CR. Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis. Psychiatry Research Neuroimaging 2021, 317: 111380. PMID: 34482052, PMCID: PMC8579376, DOI: 10.1016/j.pscychresns.2021.111380.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlzheimer's diseaseHippocampal formationUse disordersHigher Clinical Dementia Rating Scale-SumVentricular volumeVolumetric deficitsCingulate cortexClinical Dementia Rating Scale SumCoordinating CenterSmaller hippocampal volumesLarger ventricular volumesNational Alzheimer's Coordinating CenterIsthmus cingulate cortexPosterior cingulate cortexMisuse of alcoholSuperior parietal cortexDistinct brain regionsCognitive dysfunctionHippocampal volumeInferior frontal gyrusRegional GMVHigh riskDementia severityDual diagnosis
2020
Sex Differences in Neural Responses to the Perception of Social Interactions
Li G, Chen Y, Wang W, Dhingra I, Zhornitsky S, Tang X, Li CR. Sex Differences in Neural Responses to the Perception of Social Interactions. Frontiers In Human Neuroscience 2020, 14: 565132. PMID: 33061901, PMCID: PMC7518190, DOI: 10.3389/fnhum.2020.565132.Peer-Reviewed Original ResearchMiddle frontal gyrusBilateral anterior insulaAnterior insulaSocial interactionHigher activationNeural responsesRight inferior frontal cortexSex differencesPre-supplementary motor areaSocial cognition tasksParacentral lobuleRight superior temporal gyrusWhole-brain regressionInferior frontal cortexSuperior temporal gyrusLower activationMedial orbitofrontal cortexPosterior cingulate cortexHuman Connectome Project dataCognition tasksFacial emotionsNeural processesFrontal gyrusTemporal gyrusSelf-Report
2019
Concurrent amygdalar and ventromedial prefrontal cortical responses during emotion processing: a meta-analysis of the effects of valence of emotion and passive exposure versus active regulation
Yang M, Tsai SJ, Li CR. Concurrent amygdalar and ventromedial prefrontal cortical responses during emotion processing: a meta-analysis of the effects of valence of emotion and passive exposure versus active regulation. Brain Structure And Function 2019, 225: 345-363. PMID: 31863185, PMCID: PMC6960357, DOI: 10.1007/s00429-019-02007-3.Peer-Reviewed Original ResearchConceptsActivation likelihood estimationPassive exposureAmygdala activityNegative emotionsRight amygdala activityEmotion processingPosterior cingulate cortexWhole-brain analysisPrefrontal cortical responsesCortical responsesLeft amygdalaCingulate cortexVentromedial prefrontal cortexBilateral amygdalaVentral striatumPrefrontal cortexConvergent activityAmygdalaVentral precuneusEffects of valenceCortexExposureVmPFCPositive emotionsVmPFC responsesPosterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking
Le TM, Zhornitsky S, Wang W, Ide J, Zhang S, Li CR. Posterior Cingulate Cortical Response to Active Avoidance Mediates the Relationship between Punishment Sensitivity and Problem Drinking. Journal Of Neuroscience 2019, 39: 6354-6364. PMID: 31189577, PMCID: PMC6687909, DOI: 10.1523/jneurosci.0508-19.2019.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMaladaptive coping mechanismPunishment sensitivityNeural substratesBehavioral avoidanceResponse inhibitionNegative affectAlcohol usePosterior cingulate cortex activationCoping mechanismsProblem drinkingAlcohol misusePCC responseSensation-seeking traitsAvoidance strategiesAlcohol Use Disorders Identification TestHazardous alcohol useAvoidance tendenciesAlcohol Use Disorders Identification Test (AUDIT) scoresGo taskNeural processesReward QuestionnaireAction inhibitionBrain activationCerebral correlates
2018
Exploring Age-Related Changes in Resting State Functional Connectivity of the Amygdala: From Young to Middle Adulthood
Xiao T, Zhang S, Lee LE, Chao HH, van Dyck C, Li CR. Exploring Age-Related Changes in Resting State Functional Connectivity of the Amygdala: From Young to Middle Adulthood. Frontiers In Aging Neuroscience 2018, 10: 209. PMID: 30061823, PMCID: PMC6055042, DOI: 10.3389/fnagi.2018.00209.Peer-Reviewed Original ResearchResting-state functional connectivityAmygdala resting-state functional connectivityDorsal medial prefrontal cortexAnterior cingulate cortexAge-related differencesFunctional connectivityEmotion regulationAge-related changesPrefrontal cortexPositive resting-state functional connectivityNegative rsFCCingulate cortexEmotion regulatory mechanismsMiddle adulthoodVentromedial prefrontal cortexLife-span developmentState functional connectivityPosterior cingulate cortexMedial prefrontal cortexCognitive processingMaladaptive developmentAmygdala interactionsEmotional disordersIntrinsic connectivityAmygdala circuits
2017
Hemispheric lateralization of resting-state functional connectivity of the ventral striatum: an exploratory study
Zhang S, Hu S, Chao HH, Li CR. Hemispheric lateralization of resting-state functional connectivity of the ventral striatum: an exploratory study. Brain Structure And Function 2017, 222: 2573-2583. PMID: 28110447, PMCID: PMC5540792, DOI: 10.1007/s00429-016-1358-y.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPosterior cingulate cortexIntraparietal sulcusVentral striatumSupramarginal gyrusVS connectivityFunctional connectivityDorsomedial prefrontal cortexAutomated Anatomic Labeling (AAL) atlasFunctional hemispheric asymmetriesCerebral functional organizationGender differencesHuman Connectome ProjectRight lateralizationSelf-ControlHemispheric lateralizationPrefrontal cortexSaliency responsesBehavioral contingenciesFunctional lateralizationMotivated behaviorHemispheric asymmetryCingulate cortexConnectome ProjectLaterality index
2016
The Right Superior Frontal Gyrus and Individual Variation in Proactive Control of Impulsive Response
Hu S, Ide JS, Zhang S, Li CR. The Right Superior Frontal Gyrus and Individual Variation in Proactive Control of Impulsive Response. Journal Of Neuroscience 2016, 36: 12688-12696. PMID: 27974616, PMCID: PMC5157110, DOI: 10.1523/jneurosci.1175-16.2016.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeRight superior frontal gyrusSuperior frontal gyrusConflict anticipationProactive controlFrontal gyrusImpulsive responsesCognitive controlSignal taskInhibitory controlImpulse controlRegional activationEfficient response inhibitionReaction time differencesMotor urgencyVentromedial prefrontal cortexStop-signal taskYoung adultsSignal reaction timePosterior cingulate cortexIndividual variationError RTAction restraintNeural basisResponse inhibitionResting-State Functional Connectivity of the Basal Nucleus of Meynert in Cigarette Smokers: Dependence Level and Gender Differences
Zhang S, Hu S, Fucito LM, Luo X, Mazure CM, Zaborszky L, Li CR. Resting-State Functional Connectivity of the Basal Nucleus of Meynert in Cigarette Smokers: Dependence Level and Gender Differences. Nicotine & Tobacco Research 2016, 19: 452-459. PMID: 27613921, PMCID: PMC6074817, DOI: 10.1093/ntr/ntw209.Peer-Reviewed Original ResearchConceptsSupplementary motor areaCigarette smokersCholinergic systemCigarette smokingFemale smokersMotor areaBasal nucleusFunctional connectivityResting-state functional connectivityGender-matched nonsmokersWhole-brain functional connectivityNicotine dependence scoresBilateral anterior insulaNicotinic acetylcholine receptorsPosterior cingulate cortexCurrent smokersMale smokersCerebral cortexCholinergic projectionsMultiple imaging modalitiesBasal forebrainGreater negative connectivitySex-specific differencesSmokersFagerström TestChapter 24 Cerebral Gray Matter Volumes in Cocaine Dependence Clinical and Functional Implications
Li C. Chapter 24 Cerebral Gray Matter Volumes in Cocaine Dependence Clinical and Functional Implications. 2016, 245-256. DOI: 10.1016/b978-0-12-800212-4.00024-8.Peer-Reviewed Original ResearchGray matter volumeCerebral gray matter volumeSuperior frontal gyrusHealthy controlsMatter volumeCingulate cortexCD individualsMiddle/posterior cingulate cortexRight superior frontal gyrusBilateral superior frontal gyrusLoss of neuronsDuration of useVoxel-based morphometryRight ventral putamenMagnetic resonance imagingMultiple brain regionsPosterior cingulate cortexAffective functionsCerebral morphometryVasoactive effectsGMV lossVentral putamenCocaine-dependent individualsTemporal cortexCocaine abuse
2014
The effects of age on resting state functional connectivity of the basal ganglia from young to middle adulthood
Manza P, Zhang S, Hu S, Chao HH, Leung HC, Li CS. The effects of age on resting state functional connectivity of the basal ganglia from young to middle adulthood. NeuroImage 2014, 107: 311-322. PMID: 25514518, PMCID: PMC4300261, DOI: 10.1016/j.neuroimage.2014.12.016.Peer-Reviewed Original ResearchConceptsBasal gangliaNegative connectivityFunctional connectivityState functional magnetic resonanceBasal ganglia nucleiCerebral functional connectivityVentral tegmental area/substantia nigraState functional connectivityAge-related structural changesYears of agePosterior cingulate cortexMedial orbitofrontal cortexDefault mode network regionsFunctional magnetic resonanceCerebellum changesEffect of ageCerebral cortexDopaminergic dysfunctionSubstantia nigraPosterior putamenSomatomotor cortexAdults 18Motor functionVTA/SNMiddle adulthood
2013
Cerebral gray matter volumes and low-frequency fluctuation of BOLD signals in cocaine dependence: Duration of use and gender difference
Ide JS, Zhang S, Hu S, Sinha R, Mazure CM, Li CS. Cerebral gray matter volumes and low-frequency fluctuation of BOLD signals in cocaine dependence: Duration of use and gender difference. Drug And Alcohol Dependence 2013, 134: 51-62. PMID: 24090712, PMCID: PMC3865077, DOI: 10.1016/j.drugalcdep.2013.09.004.Peer-Reviewed Original ResearchConceptsGray matter volumeSuperior frontal gyrusDuration of useGM volumeMatter volumeLow-frequency fluctuationsBOLD signalCingulate cortexCD individualsCocaine useCerebral gray matter volumeAlcohol useMiddle/posterior cingulate cortexRight superior frontal gyrusGM volume lossBilateral superior frontal gyrusHealthy control subjectsRight ventral putamenMagnetic resonance imagingChronic cocaine usePosterior cingulate cortexInfluence of ageEffect of ageControl subjectsVentral putamenMethylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals
Matuskey D, Luo X, Zhang S, Morgan PT, Abdelghany O, Malison RT, Li CS. Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals. Psychiatry Research 2013, 214: 116-121. PMID: 23973363, PMCID: PMC3811038, DOI: 10.1016/j.pscychresns.2013.06.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultCentral Nervous System StimulantsCerebral CortexCocaine-Related DisordersCognition DisordersFemaleHumansImage Processing, Computer-AssistedInhibition, PsychologicalMagnetic Resonance ImagingMaleMethylphenidateMiddle AgedModels, NeurologicalNeural PathwaysNeuropsychological TestsOxygenPhotic StimulationReaction TimeConceptsFunctional magnetic resonance imagingStop-signal taskCD individualsCerebral activationPrecuneus/posterior cingulate cortexSystolic blood pressureInfluence of methylphenidateEffects of methylphenidateMagnetic resonance imagingPosterior cingulate cortexBrain imaging studiesCocaine-addicted individualsDefault mode networkAgonist therapyBlood pressureIntravenous methylphenidateCortico-striatoHealthy controlsCocaine-dependent individualsThalamic activationCingulate cortexResonance imagingBrain regionsMethylphenidateCocaine dependenceNeural Bases of Pharmacological Treatment of Nicotine Dependence - Insights from Functional Brain Imaging: A Systematic Review
Menossi HS, Goudriaan AE, de Azevedo-Marques Périco C, Nicastri S, de Andrade AG, D’Elia G, Li CS, Castaldelli-Maia JM. Neural Bases of Pharmacological Treatment of Nicotine Dependence - Insights from Functional Brain Imaging: A Systematic Review. CNS Drugs 2013, 27: 921-941. PMID: 23853032, DOI: 10.1007/s40263-013-0092-8.Peer-Reviewed Original ResearchConceptsPharmacological treatmentNicotine dependenceContinuous arterial spin labelingCingulate cortexPharmacological smoking cessation treatmentsBlood oxygen level-dependent imagingNicotine replacement therapyPositron emission tomography studySmoking cessation treatmentEffects of vareniclineMaintenance of smokingLevel-dependent imagingNicotine-dependent individualsEmission tomography studiesMore effective treatmentsFunctional magnetic resonance imagingMagnetic resonance imagingPosterior cingulate cortexArterial spin labelingWeb of ScienceLateral orbitofrontal cortexSynthesis MethodsTwoClinical characteristicsData sourcesWeNicotine replacementChanges in cerebral morphometry and amplitude of low-frequency fluctuations of BOLD signals during healthy aging: correlation with inhibitory control
Hu S, Chao H, Zhang S, Ide JS, Li CS. Changes in cerebral morphometry and amplitude of low-frequency fluctuations of BOLD signals during healthy aging: correlation with inhibitory control. Brain Structure And Function 2013, 219: 983-994. PMID: 23553547, PMCID: PMC3760988, DOI: 10.1007/s00429-013-0548-0.Peer-Reviewed Original ResearchConceptsDorsal lateral prefrontal cortexInferior parietal lobuleSupplementary motor areaFrontal regionsInhibitory controlCingulate cortexStop-signal reaction timeBilateral dorsal lateral prefrontal cortexGM volumeCognitive performance decreasesRight inferior parietal lobuleLow-frequency fluctuationsLateral prefrontal cortexSignal reaction timePosterior cingulate cortexAnterior cingulate cortexBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalFamily-wise errorGray matter volumeRecent alcohol useCognitive challengesParietal lobuleSpontaneous neural activityVoxel-based morphometry
2012
Task-Related, Low-Frequency Task-Residual, and Resting State Activity in the Default Mode Network Brain Regions
Zhang S, Li CS. Task-Related, Low-Frequency Task-Residual, and Resting State Activity in the Default Mode Network Brain Regions. Frontiers In Psychology 2012, 3: 172. PMID: 22661964, PMCID: PMC3362743, DOI: 10.3389/fpsyg.2012.00172.Peer-Reviewed Original ResearchDefault mode networkPosterior cingulate cortexBlood oxygen level-dependent (BOLD) signalLow-frequency fluctuation (fALFF) signalsLevel-dependent signalStop-signal taskCingulate cortexBrain regionsBrain functionTask-related eventsFractional amplitudePrecuneusMode networkDMN regionsSignal taskDMN activityBrain activityCognitive performanceUseful indexLatter findingRestingDMN responseTask eventsTask conditionsFALFF
2011
Neural processes of preparatory control for stop signal inhibition
Hu S, Li C. Neural processes of preparatory control for stop signal inhibition. Human Brain Mapping 2011, 33: 2785-2796. PMID: 21976392, PMCID: PMC3293936, DOI: 10.1002/hbm.21399.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeFunctional magnetic resonance imagingMotor inhibitionShorter stop-signal reaction timesPrefrontal cortexRight orbital frontal cortexMotor executionPrimary motor cortexOrbital frontal cortexSignal inhibitionMagnetic resonance imagingPosterior cingulate cortexInferior parietal lobuleRight prefrontal cortexMotor cortexSignal reaction timeBilateral putamenFrontal cortexHealthy adultsVentromedial prefrontal cortexCingulate cortexResonance imagingPreparatory inhibitionParietal lobuleStop-signal trialsDeficits in default mode network activity preceding error in cocaine dependent individuals
Bednarski SR, Zhang S, Hong KI, Sinha R, Rounsaville BJ, Li CS. Deficits in default mode network activity preceding error in cocaine dependent individuals. Drug And Alcohol Dependence 2011, 119: e51-e57. PMID: 21703783, PMCID: PMC3188675, DOI: 10.1016/j.drugalcdep.2011.05.026.Peer-Reviewed Original ResearchConceptsDefault mode networkCocaine dependenceCocaine useHealthy controlsTask-related cerebral activationBlood oxygenation level-dependent (BOLD) signalDemographics-matched healthy controlsGray matter volumeDefault mode network activityLevel-dependent signalChronic cocaine useRegional brain activationPosterior cingulate cortexStatistical parametric mappingCerebral functionBilateral precuneusCocaine-dependent individualsCerebral activationHealthy peopleMatter volumeCingulate cortexVentromedial prefrontal cortexBrain regionsCognitive deficitsCocaine misuse
2009
A neural measure of behavioral engagement: Task-residual low-frequency blood oxygenation level-dependent activity in the precuneus
Zhang S, Li CS. A neural measure of behavioral engagement: Task-residual low-frequency blood oxygenation level-dependent activity in the precuneus. NeuroImage 2009, 49: 1911-1918. PMID: 19761851, PMCID: PMC2791356, DOI: 10.1016/j.neuroimage.2009.09.004.Peer-Reviewed Original ResearchConceptsBlood oxygenation level-dependent activityRegional brain activationLevel-dependent activityTask engagementNeural measuresNeural processesBrain activationPosterior cingulate cortexAttentional monitoringResponse inhibitionHuman cognitionPrefrontal activationSignal taskGreater activationBOLD activityBehavioral engagementCingulate cortexPrecuneusBrain regionsLow-frequency fluctuationsFractional amplitudeBrain imagingSeed regionIndependent component analysisEngagement