2020
KTN1 Variants Underlying Putamen Gray Matter Volumes and Parkinson’s Disease
Mao Q, Wang X, Chen B, Fan L, Wang S, Zhang Y, Lin X, Cao Y, Wu YC, Ji J, Xu J, Zheng J, Zhang H, Zheng C, Chen W, Cheng W, Luo X, Wang K, Zuo L, Kang L, Li CR, Luo X. KTN1 Variants Underlying Putamen Gray Matter Volumes and Parkinson’s Disease. Frontiers In Neuroscience 2020, 14: 651. PMID: 32655362, PMCID: PMC7324786, DOI: 10.3389/fnins.2020.00651.Peer-Reviewed Original ResearchPutamen gray matter volumesSubstantia nigra pars compactaGray matter volumeParkinson's diseaseMRNA expressionSingle nucleotide polymorphismsPD riskIndependent cohortMatter volumeDevelopment of PDPars compactaDopaminergic neuronsPutamenPutamen volumeSignificant associationPD associationsRisk allelesDiseaseSelective lossCohortGene variants
2018
Noradrenergic Dysfunction in Alzheimer's and Parkinson's Diseases—An Overview of Imaging Studies
Peterson AC, Li CR. Noradrenergic Dysfunction in Alzheimer's and Parkinson's Diseases—An Overview of Imaging Studies. Frontiers In Aging Neuroscience 2018, 10: 127. PMID: 29765316, PMCID: PMC5938376, DOI: 10.3389/fnagi.2018.00127.Peer-Reviewed Original ResearchNoradrenergic dysfunctionParkinson's diseaseAlzheimer's diseaseDefault mode networkMRI studiesImaging studiesPathogenesis of ADPostmortem anatomical studiesConventional therapeutic strategiesControl network activityStructural MRI studiesMagnetic resonance imagingFunctional MRI studyHuman imaging studiesLC degenerationCerebral cortexNoradrenergic projectionsDopaminergic neurotransmissionNoradrenergic systemTherapeutic strategiesMedication developmentFunctional alterationsCognitive declineCognitive impairmentDysfunctionLevodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease
Manza P, Schwartz G, Masson M, Kann S, Volkow ND, Li CR, Leung HC. Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease. Neurobiology Of Aging 2018, 66: 12-22. PMID: 29501966, PMCID: PMC6436810, DOI: 10.1016/j.neurobiolaging.2018.02.003.Peer-Reviewed Original ResearchConceptsEarly-stage Parkinson's diseaseParkinson's diseaseDopaminergic medicationAdvanced Parkinson's diseaseStriatal activationResponse inhibitionRole of dopaminergicAge-matched controlsFunctional magnetic resonance imagingMagnetic resonance imagingExecutive functionLevodopa monotherapyMultiple medicationsMotor symptomsSignificant group differencesPD groupStop-signal taskAdvanced stageLevodopaResonance imagingMedicationsFunctional connectivityCritical executive functionMotor inhibitionPatients
2017
Response inhibition in Parkinson’s disease: a meta-analysis of dopaminergic medication and disease duration effects
Manza P, Amandola M, Tatineni V, Li CR, Leung HC. Response inhibition in Parkinson’s disease: a meta-analysis of dopaminergic medication and disease duration effects. Npj Parkinson's Disease 2017, 3: 23. PMID: 28702504, PMCID: PMC5501877, DOI: 10.1038/s41531-017-0024-2.Peer-Reviewed Original ResearchDopamine replacement therapyEarly-stage Parkinson's diseaseDisease durationParkinson's diseaseDopaminergic medicationDopaminergic drugsDisease patientsResponse inhibitionCognitive functionDisease duration effectHallmark motor symptomsParkinson's disease durationShorter disease durationAdvanced Parkinson's diseaseParkinson's disease patientsRole of dopamineResponse inhibition deficitsMotor symptomsBasal gangliaHealthy controlsMedication statusMedicationsPatientsCognitive deficitsNeurodegenerative disordersThe Effects of Age, from Young to Middle Adulthood, and Gender on Resting State Functional Connectivity of the Dopaminergic Midbrain
Peterson AC, Zhang S, Hu S, Chao HH, Li CR. The Effects of Age, from Young to Middle Adulthood, and Gender on Resting State Functional Connectivity of the Dopaminergic Midbrain. Frontiers In Human Neuroscience 2017, 11: 52. PMID: 28223929, PMCID: PMC5293810, DOI: 10.3389/fnhum.2017.00052.Peer-Reviewed Original ResearchSubstantia nigra pars compactaVentral tegmental areaAttention-deficit/ hyperactivity disorderState functional connectivityAge-related changesEffect of ageFunctional connectivityParahippocampal gyrusParkinson's diseaseMiddle adulthoodDopaminergic ventral tegmental areaBilateral angular gyrusOrbital frontal regionsBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalPosterior orbital gyrusTime courseNeural basisDopaminergic midbrainHyperactivity disorderNeural mechanismsAngular gyrusPars compactaFrontal regionsDopaminergic structures
2015
Resting‐state functional connectivity of the striatum in early‐stage Parkinson's disease: Cognitive decline and motor symptomatology
Manza P, Zhang S, Li C, Leung H. Resting‐state functional connectivity of the striatum in early‐stage Parkinson's disease: Cognitive decline and motor symptomatology. Human Brain Mapping 2015, 37: 648-662. PMID: 26566885, PMCID: PMC4843498, DOI: 10.1002/hbm.23056.Peer-Reviewed Original ResearchConceptsParkinson's diseaseFunctional connectivity patternsMotor deficitsFunctional connectivityRostral anterior cingulate cortexState functional connectivity patternsAnterior cingulate cortexConnectivity patternsAnterior putamenMotor symptomsSubstantia nigraDopaminergic functionHealthy controlsMotor functionDorsal caudateStriatal connectivityStriatal subregionsSymptomatic individualsMotor impairmentCingulate cortexCognitive declineNeurodegenerative disordersCognitive functionDiseaseEarly stage individuals