2020
Common and gender‐specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group
Rabin RA, Mackey S, Parvaz MA, Cousijn J, Li C, Pearlson G, Schmaal L, Sinha R, Stein E, Veltman D, Thompson PM, Conrod P, Garavan H, Alia‐Klein N, Goldstein RZ. Common and gender‐specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group. Human Brain Mapping 2020, 43: 543-554. PMID: 32857473, PMCID: PMC8675419, DOI: 10.1002/hbm.25141.Peer-Reviewed Original ResearchConceptsGray matter volumeCocaine useCocaine-dependent individualsMatter volumeCD individualsWhole-brain linear regressionAnterior insulaHippocampal gray matter volumeSelect brain areasT1-weighted MRI scansGender-specific associationsTotal intracranial volumeENIGMA Addiction Working GroupCue-induced cravingLeft anterior insulaGender-specific mechanismsAge-matched participantsCD menCD womenVoxel-based morphometry dataControl menLimbic regionsClinical dataMRI scansBrain areas
2018
Hypothalamic response to cocaine cues and cocaine addiction severity
Zhang S, Zhornitsky S, Angarita GA, Li C. Hypothalamic response to cocaine cues and cocaine addiction severity. Addiction Biology 2018, 25: e12682. PMID: 30295396, PMCID: PMC6453736, DOI: 10.1111/adb.12682.Peer-Reviewed Original ResearchConceptsCocaine Craving QuestionnaireCocaine Selective Severity AssessmentFunctional magnetic resonance imagingCocaine-dependent individualsAddiction severityOrbitofrontal cortexHypothalamic responseVentral striatumCocaine addictionCocaine cuesAngular gyrusBilateral orbitofrontal cortexBilateral visual cortexCue-induced cravingMagnetic resonance imagingMiddle frontal gyrusClinical featuresNeutral cuesDopaminergic circuitsHypothalamusVisual cortexResonance imagingDopaminergic midbrainFrontal gyrusAg response
2007
Imaging stress‐ and cue‐induced drug and alcohol craving: association with relapse and clinical implications
SINHA R, LI C. Imaging stress‐ and cue‐induced drug and alcohol craving: association with relapse and clinical implications. Drug And Alcohol Review 2007, 26: 25-31. PMID: 17364833, DOI: 10.1080/09595230601036960.Peer-Reviewed Original ResearchConceptsRelapse outcomesDrug-related cuesPosterior insula regionsCue-induced cravingDrug cue exposureCue-induced drugBrain imaging studiesDrug cuesNeural correlatesCorticostriatal-limbic circuitryCue exposureInsula regionsBrain correlatesRelapse propensityMedial prefrontalBehavioral treatmentAddictive disordersAlcohol cravingPosterior cingulateNeural activityBrain regionsArousal responseLimbic circuitryNeural circuitsCraving
2005
Neuroimaging study of sex differences in the neuropathology of cocaine abuse
Li CS, Kemp K, Milivojevic V, Sinha R. Neuroimaging study of sex differences in the neuropathology of cocaine abuse. Gender Medicine 2005, 2: 174-182. PMID: 16290890, DOI: 10.1016/s1550-8579(05)80046-4.Peer-Reviewed Original ResearchConceptsRegional brain activationBrain activationGreater activationBrain regionsSex differencesScript-guided imagerySubstance abusersCerebral perfusion deficitsBlood oxygenation level-dependent (BOLD) signalSame statistical thresholdCocaine-dependent menCue-induced cravingSuperior frontal gyrusLevel-dependent signalChronic cocaine useMale substance abusersSex-related factorsCocaine use disorderImportant sex differencesLeft uncusStress trialsClinical outcomesPerfusion deficitsRight claustrumPharmacologic challenge