2020
Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus
Jin SC, Dong W, Kundishora AJ, Panchagnula S, Moreno-De-Luca A, Furey CG, Allocco AA, Walker RL, Nelson-Williams C, Smith H, Dunbar A, Conine S, Lu Q, Zeng X, Sierant MC, Knight JR, Sullivan W, Duy PQ, DeSpenza T, Reeves BC, Karimy JK, Marlier A, Castaldi C, Tikhonova IR, Li B, Peña HP, Broach JR, Kabachelor EM, Ssenyonga P, Hehnly C, Ge L, Keren B, Timberlake AT, Goto J, Mangano FT, Johnston JM, Butler WE, Warf BC, Smith ER, Schiff SJ, Limbrick DD, Heuer G, Jackson EM, Iskandar BJ, Mane S, Haider S, Guclu B, Bayri Y, Sahin Y, Duncan CC, Apuzzo MLJ, DiLuna ML, Hoffman EJ, Sestan N, Ment LR, Alper SL, Bilguvar K, Geschwind DH, Günel M, Lifton RP, Kahle KT. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nature Medicine 2020, 26: 1754-1765. PMID: 33077954, PMCID: PMC7871900, DOI: 10.1038/s41591-020-1090-2.Peer-Reviewed Original ResearchConceptsCongenital hydrocephalusPoor neurodevelopmental outcomesPost-surgical patientsCerebrospinal fluid accumulationNeural stem cell biologyGenetic disruptionWhole-exome sequencingPrimary pathomechanismEarly brain developmentNeurodevelopmental outcomesHigh morbidityCSF diversionMutation burdenFluid accumulationBrain ventriclesCH casesBrain developmentDe novo mutationsPatientsExome sequencingCSF dynamicsDisease mechanismsHydrocephalusNovo mutationsCell types
1984
Perinatal management of meningomyelocele.
Chervenak F, Duncan C, Ment L, Tortora M, McClure M, Hobbins J. Perinatal management of meningomyelocele. Obstetrics And Gynecology 1984, 63: 376-80. PMID: 6700861.Peer-Reviewed Original ResearchConceptsPerinatal managementLow transverse cesarean sectionFetal pulmonic maturityAbdominal deliveryCesarean sectionSerial sonographyNeonatal managementObstetric managementThird trimesterSonographic diagnosisFetal spineTeam approachMeningomyeloceleEarly closureSpinal defectsOptimal outcomesTrimesterManagementHydrocephalusNeonatesSonographyShuntingDiagnosisSpinePosthemorrhagic hydrocephalus. Low incidence in very low birth weight neonates with intraventricular hemorrhage.
Ment L, Duncan C, Scott D, Ehrenkranz R. Posthemorrhagic hydrocephalus. Low incidence in very low birth weight neonates with intraventricular hemorrhage. Journal Of Neurosurgery 1984, 60: 343-7. PMID: 6693962, DOI: 10.3171/jns.1984.60.2.0343.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageCerebral VentriclesHumansHydrocephalusInfant, Low Birth WeightInfant, NewbornInfant, PrematureConceptsIntraventricular hemorrhagePosthemorrhagic hydrocephalusLong-term neurodevelopmental handicapsNewborn Special Care UnitLow birth weight neonatesCranial ultrasound scanningCranial ultrasound studiesBirth weight neonatesBirth weight rangeCongenital aqueductal stenosisElevated intracranial pressureSpecial care unitsOccipitofrontal head circumferenceNon-hemorrhage groupNeurodevelopmental handicapPreterm infantsWeight neonatesCare unitPostnatal hoursAqueductal stenosisBirth weightEqual incidenceIntracranial pressureHead circumferenceGerminal matrix
1983
The diagnosis of fetal hydrocephalus
Chervenak F, Berkowitz R, Romero R, Tortora M, Mayden K, Duncan C, Mahoney M, Hobbins J. The diagnosis of fetal hydrocephalus. American Journal Of Obstetrics And Gynecology 1983, 147: 703-716. PMID: 6685439, DOI: 10.1016/0002-9378(83)90456-8.Peer-Reviewed Original ResearchMeSH KeywordsFemaleFetal DiseasesGestational AgeHumansHydrocephalusInfant, NewbornPregnancyRadiographyUltrasonography
1982
Neonates of less than or equal to 1,250 grams birth weight: prospective neurodevelopmental evaluation during the first year post-term.
Ment L, Scott D, Ehrenkranz R, Rothman S, Duncan C, Warshaw J. Neonates of less than or equal to 1,250 grams birth weight: prospective neurodevelopmental evaluation during the first year post-term. Pediatrics 1982, 70: 292-6. PMID: 7099799, DOI: 10.1542/peds.70.2.292.Peer-Reviewed Original ResearchConceptsNeonatal intensive careIntraventricular hemorrhagePreterm neonatesIntensive careBirth weightIncidence of IVHNewborn Special Care UnitSophisticated neonatal intensive careGm birth weightGrams birth weightIll preterm neonatesSpecial care unitsConsecutive preterm neonatesYears of lifeNeurodevelopmental handicapCare unitPostnatal hoursProspective studyNeurodevelopmental evaluationMotor handicapEarly identificationGreater riskNeonatesDelayed acquisitionDevelopmental problems
1981
Benign enlargement of the subarachnoid spaces in the infant.
Ment L, Duncan C, Geehr R. Benign enlargement of the subarachnoid spaces in the infant. Journal Of Neurosurgery 1981, 54: 504-8. PMID: 7205351, DOI: 10.3171/jns.1981.54.4.0504.Peer-Reviewed Original ResearchMeSH KeywordsHeadHematoma, SubduralHumansHydrocephalusInfant, NewbornSubarachnoid SpaceTomography, X-Ray Computed