2020
Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus
Jin SC, Dong W, Kundishora AJ, Panchagnula S, Moreno-De-Luca A, Furey CG, Allocco AA, Walker RL, Nelson-Williams C, Smith H, Dunbar A, Conine S, Lu Q, Zeng X, Sierant MC, Knight JR, Sullivan W, Duy PQ, DeSpenza T, Reeves BC, Karimy JK, Marlier A, Castaldi C, Tikhonova IR, Li B, Peña HP, Broach JR, Kabachelor EM, Ssenyonga P, Hehnly C, Ge L, Keren B, Timberlake AT, Goto J, Mangano FT, Johnston JM, Butler WE, Warf BC, Smith ER, Schiff SJ, Limbrick DD, Heuer G, Jackson EM, Iskandar BJ, Mane S, Haider S, Guclu B, Bayri Y, Sahin Y, Duncan CC, Apuzzo MLJ, DiLuna ML, Hoffman EJ, Sestan N, Ment LR, Alper SL, Bilguvar K, Geschwind DH, Günel M, Lifton RP, Kahle KT. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nature Medicine 2020, 26: 1754-1765. PMID: 33077954, PMCID: PMC7871900, DOI: 10.1038/s41591-020-1090-2.Peer-Reviewed Original ResearchConceptsCongenital hydrocephalusPoor neurodevelopmental outcomesPost-surgical patientsCerebrospinal fluid accumulationNeural stem cell biologyGenetic disruptionWhole-exome sequencingPrimary pathomechanismEarly brain developmentNeurodevelopmental outcomesHigh morbidityCSF diversionMutation burdenFluid accumulationBrain ventriclesCH casesBrain developmentDe novo mutationsPatientsExome sequencingCSF dynamicsDisease mechanismsHydrocephalusNovo mutationsCell types
2001
Neonatal auditory activation detected by functional magnetic resonance imaging
Anderson A, Marois R, Colson E, Peterson B, Duncan C, Ehrenkranz R, Schneider K, Gore J, Ment L. Neonatal auditory activation detected by functional magnetic resonance imaging. Magnetic Resonance Imaging 2001, 19: 1-5. PMID: 11295339, DOI: 10.1016/s0730-725x(00)00231-9.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingAuditory stimulationSuperior temporal regionsSuperior temporal gyrusAuditory cortical activationMagnetic resonance imagingFunctional brain imagingBlood oxygen level-dependent (BOLD) signalLevel-dependent signalBOLD signal responseAuditory stimuliBrain activationFMRI studyAuditory activationTemporal gyrusResonance imagingBOLD responseCortical activationHuman infantsTemporal regionsAdult control subjectsBrain imagingHealthy neonatesPure tonesControl subjects
2000
Regional Brain Volume Abnormalities and Long-term Cognitive Outcome in Preterm Infants
Peterson B, Vohr B, Staib L, Cannistraci C, Dolberg A, Schneider K, Katz K, Westerveld M, Sparrow S, Anderson A, Duncan C, Makuch R, Gore J, Ment L. Regional Brain Volume Abnormalities and Long-term Cognitive Outcome in Preterm Infants. JAMA 2000, 284: 1939-1947. PMID: 11035890, DOI: 10.1001/jama.284.15.1939.Peer-Reviewed Original ResearchConceptsRegional brain volumesLong-term cognitive outcomesPreterm childrenPreterm infantsBrain volumeBasal gangliaCorpus callosumCognitive outcomesRegional brain volume abnormalitiesTerm control childrenCase-control studyBrain volume abnormalitiesPoor cognitive outcomesRegional cortical volumesStructural magnetic resonanceMidtemporal cortexPreterm birthPremature birthTemporal hornPerinatal variablesSubgenual cortexUniversity Medical SchoolCortical volumeHigh prevalenceLongitudinal followSpontaneously Infected Cephalohematoma: Case Report and Review of the Literature
Goodwin M, Persing J, Duncan C, Shin J. Spontaneously Infected Cephalohematoma: Case Report and Review of the Literature. Journal Of Craniofacial Surgery 2000, 11: 371-375. PMID: 11314386, DOI: 10.1097/00001665-200011040-00017.Peer-Reviewed Original ResearchOutcome of Children in the Indomethacin Intraventricular Hemorrhage Prevention Trial
Ment L, Vohr B, Allan W, Westerveld M, Sparrow S, Schneider K, Katz K, Duncan C, Makuch R. Outcome of Children in the Indomethacin Intraventricular Hemorrhage Prevention Trial. Pediatrics 2000, 105: 485-491. PMID: 10699097, DOI: 10.1542/peds.105.3.485.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Inflammatory Agents, Non-SteroidalBrain Damage, ChronicCerebral HemorrhageCerebral VentriclesChild, PreschoolDose-Response Relationship, DrugFemaleFollow-Up StudiesHumansIndomethacinInfantInfant, NewbornInfant, Premature, DiseasesMaleNeurologic ExaminationNeuropsychological TestsPregnancyConceptsLow-dose indomethacinIntraventricular hemorrhagePlacebo childrenIndomethacin therapyPreterm infantsEarly administrationNeurologic examinationPrevention trialsLow birth weight preterm infantsStudy childrenBirth weight preterm infantsSeverity of IVHLow birth weight survivorsMean gestational ageWeight preterm infantsAdverse neurodevelopmental outcomesOutcome of childrenStandard neurologic examinationYears of ageNeurodevelopmental handicapPreterm neonatesNeurodevelopmental examinationNeurodevelopmental outcomesCerebral palsyGestational age
1996
Three cases of symptom change in Tourette's syndrome and obsessive-compulsive disorder associated with paediatric cerebral malignancies.
Peterson B, Bronen R, Duncan C. Three cases of symptom change in Tourette's syndrome and obsessive-compulsive disorder associated with paediatric cerebral malignancies. Journal Of Neurology Neurosurgery & Psychiatry 1996, 61: 497. PMID: 8937345, PMCID: PMC1074048, DOI: 10.1136/jnnp.61.5.497.Peer-Reviewed Case Reports and Technical NotesConceptsGilles de la Tourette's syndromeObsessive-compulsive disorderCerebral malignanciesTourette syndromeTumor progressionNeurobiology of OCDLa Tourette's syndromeImportant neural substrateChart reviewNeuropsychiatric symptomsTic symptomsTumor locationSpecialty clinicCorpus callosumRadiographic documentationSymptom generationLimbic systemCaudate nucleusIntracranial lesionsSymptom changeBrain regionsSymptom severitySyndromeVentral striatumMalignancy
1995
Antenatal steroids, delivery mode, and intraventricular hemorrhage in preterm infants
Ment L, Oh W, Ehrenkranz R, Philip A, Duncan C, Makuch R. Antenatal steroids, delivery mode, and intraventricular hemorrhage in preterm infants. American Journal Of Obstetrics And Gynecology 1995, 172: 795-800. PMID: 7892866, DOI: 10.1016/0002-9378(95)90001-2.Peer-Reviewed Original ResearchConceptsEarly intraventricular hemorrhageAntenatal steroidsIntraventricular hemorrhageCesarean sectionPreterm infantsAntenatal steroid treatmentCesarean section deliveryHours of lifeMore vaginal deliveriesDelivery modePostnatal indomethacinSection deliveryWeight infantsSteroid treatmentVaginal deliveryHemorrhageInfantsSteroidsIndependent roleHoursDeliveryMulticenterIndomethacinTrialsEchoencephalography
1994
Low-dose indomethacin therapy and extension of intraventricular hemorrhage: A multicenter randomized trial
Ment L, Oh W, Ehrenkranz R, Phillip A, Vohr B, Allan W, Makuch R, Taylor K, Schneider K, Katz K, Scott D, Duncan C. Low-dose indomethacin therapy and extension of intraventricular hemorrhage: A multicenter randomized trial. The Journal Of Pediatrics 1994, 124: 951-955. PMID: 8201485, DOI: 10.1016/s0022-3476(05)83191-9.Peer-Reviewed Original ResearchConceptsLow-grade intraventricular hemorrhageIntraventricular hemorrhageAdverse eventsBirth weightLow birth weight infantsDistribution of hemorrhageGrade intraventricular hemorrhageBirth weight infantsPlacebo-controlled trialPercentage of infantsPatent ductus arteriosusGm birth weightHours of ageIndomethacin therapyWeight infantsApgar scoreParenchymal involvementSaline placeboDuctus arteriosusGestational ageIntracranial hemorrhagePostnatal hoursCascade of eventsPatent ductusCranial sonogramsLow-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial.
Ment L, Ehrenkranz R, Duncan C, Scott D, Taylor K, Katz K, Schneider K, Makuch R, Oh W, Vohr B, Philip A, Allan W. Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial. Pediatrics 1994, 93: 543-50. PMID: 8134206, DOI: 10.1542/peds.93.4.543.Peer-Reviewed Original ResearchConceptsLow birth weight neonatesSeverity of IVHBirth weight neonatesIntraventricular hemorrhageWeight neonatesDose indomethacinBirth weightGrade 4 intraventricular hemorrhageSerial cranial ultrasound examinationsSignificant adverse drug eventsPercent of neonatesPlacebo-controlled trialPatent ductus arteriosusCranial ultrasound examinationMajor risk factorAdverse drug eventsHours of ageFirst postnatal dayDuctal closureProphylactic indomethacinApgar scoreNeurodevelopmental handicapParenchymal involvementPlacebo groupAdverse events
1992
Risk factors for early intraventricular hemorrhage in low birth weight infants
Ment L, Oh W, Philip A, Ehrenkranz R, Duncan C, Allan W, Taylor K, Schneider K, Katz K, Makuch R. Risk factors for early intraventricular hemorrhage in low birth weight infants. The Journal Of Pediatrics 1992, 121: 776-783. PMID: 1432433, DOI: 10.1016/s0022-3476(05)81915-8.Peer-Reviewed Original ResearchConceptsGMH/IVHBirth weightRisk factorsIntraventricular hemorrhageLow birth weight infantsBirth weight infantsMaternal risk factorsGm birth weightMore vaginal deliveriesIndependent prognostic indicatorGerminal matrix hemorrhageHigh-grade hemorrhageRisk factor dataGroups of infantsMode of deliveryEarly intraventricular hemorrhagePrimary hospitalizationSevere IVHTocolytic useWeight infantsPreterm infantsVaginal deliveryVertex presentationGestational ageIVH group
1988
Randomized low-dose indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates
Ment L, Duncan C, Ehrenkranz R, Kleinman C, Taylor K, Scott D, Gettner P, Sherwonit E, Williams J. Randomized low-dose indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates. The Journal Of Pediatrics 1988, 112: 948-955. PMID: 3373405, DOI: 10.1016/s0022-3476(88)80225-7.Peer-Reviewed Original ResearchConceptsIntraventricular hemorrhageGerminal matrixPostnatal hoursUrinary outputDay 5Placebo-controlled prospective trialLow birth weight neonatesDuctus arteriosus shuntIndomethacin-treated infantsSerum indomethacin levelsBirth weight neonatesCardiac ultrasound studiesAdequate urinary outputGroups of infantsIndomethacin trialStudy medicationApgar scorePreterm neonatesProspective trialWeight neonatesDuctus arteriosusGestational ageSerum electrolytesBirth weightPatent ductus
1986
Beagle puppy model of perinatal cerebral insults. Cerebral blood flow changes and intraventricular hemorrhage evoked by hypoxemia.
Ment L, Stewart W, Duncan C, Pitt B. Beagle puppy model of perinatal cerebral insults. Cerebral blood flow changes and intraventricular hemorrhage evoked by hypoxemia. Journal Of Neurosurgery 1986, 65: 847-50. PMID: 3772483, DOI: 10.3171/jns.1986.65.6.0847.Peer-Reviewed Original ResearchConceptsCerebral blood flowWhite matterIntraventricular hemorrhageRegional cerebral blood flowCerebral blood flow changesNeonatal cerebral infarctionPerinatal cerebral insultsParieto-occipital white matterEffects of hypoxemiaBeagle puppy modelNewborn beagle pupsBlood flow changesTemporal white matterParietal white matterCentral gray regionNeuropathological injuryCerebral infarctionPerinatal asphyxiaCerebral insultNeuropathological changesPuppy modelCommon causeGerminal matrixBeagle pupsBlood flowBeagle puppy model of perinatal cerebral infarction. Regional cerebral prostaglandin changes during acute hypoxemia.
Ment L, Stewart W, Duncan C, Pitt B, Cole J. Beagle puppy model of perinatal cerebral infarction. Regional cerebral prostaglandin changes during acute hypoxemia. Journal Of Neurosurgery 1986, 65: 851-5. PMID: 3772484, DOI: 10.3171/jns.1986.65.6.0851.Peer-Reviewed Original ResearchConceptsCerebral blood flowPerinatal cerebral infarctionPeriventricular white matterCerebral infarctionHypoxemic insultWhite matterStable metaboliteGray matterLocal cerebral blood flowArterial blood pressureEffects of hypoxemiaBeagle puppy modelNewborn beagle pupsSignificant differencesAcute hypoxemiaProstaglandin changesNeuropathological alterationsBlood pressureIndwelling catheterNeuropathological changesIntensive carePuppy modelUncommon findingProstaglandin levelsCommon cause
1985
Intraventricular hemorrhage in a term neonate secondary to a third ventricular AVM. Case report.
Heafner M, Duncan C, Kier E, Ment L, Scott D, Kolaski R, Sorgen C. Intraventricular hemorrhage in a term neonate secondary to a third ventricular AVM. Case report. Journal Of Neurosurgery 1985, 63: 640-3. PMID: 3875699, DOI: 10.3171/jns.1985.63.4.0640.Peer-Reviewed Original ResearchConceptsIntraventricular hemorrhageUncomplicated full-term gestationsFull-term neonatesFull-term gestationDays of lifeMonths of ageDigital subtraction arteriographyDays of ageAcute onsetPostoperative courseTerm neonatesHealthy infantsSeizure disorderArteriovenous malformationsDifferential diagnosisThird ventricleComputerized tomographyYoung infantsHemorrhageArteriographyAngiomaNeonatesInfantsDiagnosisAgeAdjuvant chemotherapy for medulloblastoma
McIntosh S, Chen M, Sartain P, Duncan C, Fishburn R, Klatskin E, Schwartz A, Venes J. Adjuvant chemotherapy for medulloblastoma. Cancer 1985, 56: 1316-1319. PMID: 4027871, DOI: 10.1002/1097-0142(19850915)56:6<1316::aid-cncr2820560616>3.0.co;2-d.Peer-Reviewed Original ResearchHuman Eastern Equine Encephalitis: Electron Microscopic Study of a Brain Biopsy
Kim J, Booss J, Manuelidis E, Duncan C. Human Eastern Equine Encephalitis: Electron Microscopic Study of a Brain Biopsy. American Journal Of Clinical Pathology 1985, 84: 223-227. PMID: 4025229, DOI: 10.1093/ajcp/84.2.223.Peer-Reviewed Original ResearchEarly Childhood Developmental Follow-Up of Infants with GMH/IVH: Effect of Methylxanthine Therapy
Ment L, Scott D, Ehrenkranz R, Duncan C. Early Childhood Developmental Follow-Up of Infants with GMH/IVH: Effect of Methylxanthine Therapy. American Journal Of Perinatology 1985, 2: 223-227. PMID: 4015773, DOI: 10.1055/s-2007-999955.Peer-Reviewed Original ResearchConceptsGMH/IVHMethylxanthine therapyCerebral blood flowBlood flowSmall preterm neonatesBayley mental scoresIdiopathic apneaBirthweight neonatesPreterm neonatesIntraventricular hemorrhageNeurodevelopmental outcomesNeonatal periodMental scoresGerminal matrixTherapyIVHUnderlying disturbanceInfantsAdverse effectsFurther studiesNeonatesCognitive functioningHarmful effectsMetabolismApneaCranial Asymmetry and Lambdoid Synostosis in a Sibship
Lohse D, Duncan C, Ment L. Cranial Asymmetry and Lambdoid Synostosis in a Sibship. Neurosurgery 1985, 16: 836-838. PMID: 4010909, DOI: 10.1227/00006123-198506000-00020.Peer-Reviewed Original ResearchConceptsSevere cyanotic congenital heart diseaseCyanotic congenital heart diseaseHypoxic cerebral injuryCongenital heart diseaseCranial asymmetryAutosomal dominant hereditary conditionPosterior sagittal sutureCerebral injurySystemic diseaseHeart diseaseCerebral growthRare caseHereditary conditionCongenital diseaseTrue synostosisLambdoid synostosisOlder childrenDiseaseSynostosisSagittal sutureOlder siblingsRight portionSiblingsCraniosynostosisChildrenNeurodevelopmental assessment of very low birth weight neonates: Effect of germinal matrix and intraventricular hemorrhage
Ment L, Scott D, Ehrenkranz R, Duncan C. Neurodevelopmental assessment of very low birth weight neonates: Effect of germinal matrix and intraventricular hemorrhage. Pediatric Neurology 1985, 1: 164-168. PMID: 3880401, DOI: 10.1016/0887-8994(85)90058-x.Peer-Reviewed Original ResearchConceptsGMH/IVHIntraventricular hemorrhageNeurodevelopmental assessmentGerminal matrixSurviving infantsNeonatal germinal matrix hemorrhageNewborn Special Care UnitLow birth weight neonatesBirth weight neonatesGerminal matrix hemorrhageMajor neurologic abnormalitiesSpecial care unitsNon-hemorrhage groupWeight neonatesCare unitGroup infantsPostnatal hoursNeurologic abnormalitiesBirth weightSevere gradesHemorrhageDevelopmental scoresBayley ScalesInfantsInfant developmentCongenital cerebellar medulloblastoma
Kim J, Duncan C, Manuelidis E. Congenital cerebellar medulloblastoma. World Neurosurgery 1985, 23: 75-81. PMID: 3964981, DOI: 10.1016/0090-3019(85)90164-8.Peer-Reviewed Original Research