2020
Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus
Jin SC, Dong W, Kundishora AJ, Panchagnula S, Moreno-De-Luca A, Furey CG, Allocco AA, Walker RL, Nelson-Williams C, Smith H, Dunbar A, Conine S, Lu Q, Zeng X, Sierant MC, Knight JR, Sullivan W, Duy PQ, DeSpenza T, Reeves BC, Karimy JK, Marlier A, Castaldi C, Tikhonova IR, Li B, Peña HP, Broach JR, Kabachelor EM, Ssenyonga P, Hehnly C, Ge L, Keren B, Timberlake AT, Goto J, Mangano FT, Johnston JM, Butler WE, Warf BC, Smith ER, Schiff SJ, Limbrick DD, Heuer G, Jackson EM, Iskandar BJ, Mane S, Haider S, Guclu B, Bayri Y, Sahin Y, Duncan CC, Apuzzo MLJ, DiLuna ML, Hoffman EJ, Sestan N, Ment LR, Alper SL, Bilguvar K, Geschwind DH, Günel M, Lifton RP, Kahle KT. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nature Medicine 2020, 26: 1754-1765. PMID: 33077954, PMCID: PMC7871900, DOI: 10.1038/s41591-020-1090-2.Peer-Reviewed Original ResearchConceptsCongenital hydrocephalusPoor neurodevelopmental outcomesPost-surgical patientsCerebrospinal fluid accumulationNeural stem cell biologyGenetic disruptionWhole-exome sequencingPrimary pathomechanismEarly brain developmentNeurodevelopmental outcomesHigh morbidityCSF diversionMutation burdenFluid accumulationBrain ventriclesCH casesBrain developmentDe novo mutationsPatientsExome sequencingCSF dynamicsDisease mechanismsHydrocephalusNovo mutationsCell types
1993
Intraventricular Hemorrhage and Prematurity
Duncan C, Ment L. Intraventricular Hemorrhage and Prematurity. Neurosurgery Clinics Of North America 1993, 4: 727-734. PMID: 8241793, DOI: 10.1016/s1042-3680(18)30562-x.Peer-Reviewed Original ResearchConceptsIntraventricular hemorrhageRisk of hemorrhageCerebral blood flowGerminal matrix tissueDiagnostic imaging techniquesPosthemorrhagic hydrocephalusPreterm neonatesClinical manifestationsBlood flowVentricular systemHemorrhageCapillary bedMatrix tissueImaging techniquesPossible rupturePrematurityHydrocephalusNeonatesNeuropathologyParenchymaBrain
1985
1669 OUTCOME IN CHILDREN WITH PRENATALLY DIAGN0SED CONGENITAL HYDROCEPHALUS
Duncan C, Chervenak F, Ment L, Scott D, Ehrenkranz R, Pearson H. 1669 OUTCOME IN CHILDREN WITH PRENATALLY DIAGN0SED CONGENITAL HYDROCEPHALUS. Pediatric Research 1985, 19: 389-389. DOI: 10.1203/00006450-198504000-01693.Peer-Reviewed Original ResearchCongenital hydrocephalusVentriculo-peritoneal shuntingPoor outcomeVentricular sizeNeonatal periodIntracranial cystsBiparietal diameterHydrocephalusRelated infectionsSequential examinationsStanford-Binet scoresOutcome evaluationWkDiagnosisChildrenHigh rateInfectionScoresOutcomesYear intervalEarly stagesMyelomeningocoelePregnancyEncephalocoeleGestation
1984
Perinatal management of meningomyelocele.
Chervenak F, Duncan C, Ment L, Tortora M, McClure M, Hobbins J. Perinatal management of meningomyelocele. Obstetrics And Gynecology 1984, 63: 376-80. PMID: 6700861.Peer-Reviewed Original ResearchConceptsPerinatal managementLow transverse cesarean sectionFetal pulmonic maturityAbdominal deliveryCesarean sectionSerial sonographyNeonatal managementObstetric managementThird trimesterSonographic diagnosisFetal spineTeam approachMeningomyeloceleEarly closureSpinal defectsOptimal outcomesTrimesterManagementHydrocephalusNeonatesSonographyShuntingDiagnosisSpine
1983
The diagnosis of fetal hydrocephalus
Chervenak F, Berkowitz R, Romero R, Tortora M, Mayden K, Duncan C, Mahoney M, Hobbins J. The diagnosis of fetal hydrocephalus. American Journal Of Obstetrics And Gynecology 1983, 147: 703-716. PMID: 6685439, DOI: 10.1016/0002-9378(83)90456-8.Peer-Reviewed Original Research