2018
Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis
Aryal B, Singh AK, Zhang X, Varela L, Rotllan N, Goedeke L, Chaube B, Camporez JP, Vatner DF, Horvath TL, Shulman GI, Suárez Y, Fernández-Hernando C. Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis. JCI Insight 2018, 3: e97918. PMID: 29563332, PMCID: PMC5926923, DOI: 10.1172/jci.insight.97918.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipose TissueAllelesAngiopoietin-Like Protein 4AnimalsAtherosclerosisBody WeightChemokinesCytokinesDiet, High-FatDiet, WesternFatty AcidsGene Expression ProfilingGene Expression RegulationGene Knockout TechniquesGlucoseInsulinIntegrasesIntercellular Signaling Peptides and ProteinsLipid MetabolismLipoprotein LipaseLipoproteinsLiverMaleMiceMice, Inbred C57BLMice, KnockoutMusclesObesityProprotein Convertase 9TriglyceridesConceptsAngiopoietin-like protein 4High-fat dietEctopic lipid depositionLipid depositionGlucose toleranceLipoprotein lipaseShort-term high-fat dietSevere metabolic abnormalitiesProgression of atherosclerosisMajor risk factorTriacylglycerol-rich lipoproteinsFatty acid uptakeAdipose tissue resultsProatherogenic lipoproteinsCardiometabolic diseasesMetabolic abnormalitiesKO miceRisk factorsWhole body lipidMetabolic disordersGlucose metabolismLPL activityAdipose tissueGenetic ablationRapid clearance
2015
Dietary lipids modulate the expression of miR‐107, an miRNA that regulates the circadian system
Daimiel‐Ruiz L, Klett‐Mingo M, Konstantinidou V, Micó V, Aranda JF, García B, Martínez‐Botas J, Dávalos A, Fernández‐Hernando C, Ordovás JM. Dietary lipids modulate the expression of miR‐107, an miRNA that regulates the circadian system. Molecular Nutrition & Food Research 2015, 59: 552-565. PMID: 25522185, PMCID: PMC4591752, DOI: 10.1002/mnfr.201400616.Peer-Reviewed Original ResearchConceptsCardiovascular diseaseMiR-107Cardio-protective effectsType 2 diabetesUnhealthy dietary habitsCircadian rhythmCaco-2 cellsCVD riskConjugated linoleic acidPharmacological treatmentProtective effectDietary habitsMetabolic disordersDietary lipidsPutative target genesDocosahexanoic acidRelevant transcription factorsMultiple metabolic pathwaysRole of miRNAsOwn promoterTranscription factorsTarget genesDiseaseGene resultsGene expression