2019
Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution
Gao R, Asano SM, Upadhyayula S, Pisarev I, Milkie DE, Liu TL, Singh V, Graves A, Huynh GH, Zhao Y, Bogovic J, Colonell J, Ott CM, Zugates C, Tappan S, Rodriguez A, Mosaliganti KR, Sheu SH, Pasolli HA, Pang S, Xu CS, Megason SG, Hess H, Lippincott-Schwartz J, Hantman A, Rubin GM, Kirchhausen T, Saalfeld S, Aso Y, Boyden ES, Betzig E. Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution. Science 2019, 363 PMID: 30655415, PMCID: PMC6481610, DOI: 10.1126/science.aau8302.Peer-Reviewed Original ResearchConceptsDopaminergic neuronsDendritic spinesMouse cortexPresynaptic densitySynaptic proteinsBrain regionsLarge-scale studiesCortical columnsLattice light-sheet microscopyNeural activityNeural developmentSpecific molecular constituentsBrainLight-sheet microscopyDegree of stereotypyNanoscale spatial relationshipExpansion microscopy
2017
A connectome of a learning and memory center in the adult Drosophila brain
Takemura SY, Aso Y, Hige T, Wong A, Lu Z, Xu CS, Rivlin PK, Hess H, Zhao T, Parag T, Berg S, Huang G, Katz W, Olbris DJ, Plaza S, Umayam L, Aniceto R, Chang LA, Lauchie S, Ogundeyi O, Ordish C, Shinomiya A, Sigmund C, Takemura S, Tran J, Turner GC, Rubin GM, Scheffer LK. A connectome of a learning and memory center in the adult Drosophila brain. ELife 2017, 6: e26975. PMID: 28718765, PMCID: PMC5550281, DOI: 10.7554/elife.26975.Peer-Reviewed Original ResearchConceptsMB output neuronsDopaminergic neuronsKenyon cellsΑ-lobeMushroom bodiesAdult Drosophila brainUnderlying neuronal circuitsDirect synapseSlow depolarizationNeuronal circuitsSynaptic connectionsMemory centerDrosophila brainSynapsesNeuronsMemory formationOutput neuronsMajor siteSensory informationDAN activationSparse activitySensory modalitiesMemory recallUnanticipated classBrain