Featured Publications
Sex differences in brain gene expression among suicide completers
Cabrera-Mendoza B, Fresno C, Monroy-Jaramillo N, Fries GR, Walss-Bass C, Glahn DC, Ostrosky-Wegman P, Mendoza-Morales RC, García-Dolores F, Díaz-Otañez CE, González-Sáenz EE, Genis-Mendoza AD, Martínez-Magaña JJ, Romero-Pimentel AL, Flores G, Vázquez-Roque RA, Nicolini H. Sex differences in brain gene expression among suicide completers. Journal Of Affective Disorders 2020, 267: 67-77. PMID: 32063575, DOI: 10.1016/j.jad.2020.01.167.Peer-Reviewed Original ResearchConceptsBrain gene expressionSex-specific gene expression patternsGene expressionRibonucleic protein complexesGene expression patternsGene expression profilesProtein complexesGene setsDNA bindingExpression patternsExpression profilesGenesSuicide geneBiological levelsVesicular functionCell proliferationValuable foundationDifferentiallyMicroarrayExpressionSex-specific factorsSuicide completersSuicidal brainImmune responseSex differencesCandidate pharmacological treatments for substance use disorder and suicide identified by gene co‐expression network‐based drug repositioning
Cabrera‐Mendoza B, Martínez‐Magaña J, Monroy‐Jaramillo N, Genis‐Mendoza A, Fresno C, Fries GR, Walss‐Bass C, Armenta M, García‐Dolores F, Díaz‐Otañez C, Flores G, Vázquez‐Roque R, Nicolini H. Candidate pharmacological treatments for substance use disorder and suicide identified by gene co‐expression network‐based drug repositioning. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2021, 186: 193-206. PMID: 33403748, DOI: 10.1002/ajmg.b.32830.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersBrain gene co-expression networksHub genesPotential pharmacological targetPost-mortem samplesPharmacological treatmentHigh riskCandidate treatmentPharmacological targetsSuicidal behaviorMAOA inhibitorsPrefrontal cortexNonsuicidesDGIdb databaseGene expression profilesPatientsCo-expression networkSuicideDisordersDrugsTreatmentDrug repositioningExpression profilesIndividualsBrain Gene Expression Profiling of Individuals With Dual Diagnosis Who Died by Suicide
Cabrera-Mendoza B, Fresno C, Monroy-Jaramillo N, Fries GR, Walss-Bass C, Glahn DC, Ostrosky-Wegman P, Genis-Mendoza AD, Martínez-Magaña JJ, Romero-Pimentel AL, Díaz-Otañez CE, García-Dolores F, González-Sáenz EE, Mendoza-Morales RC, Flores G, Vázquez-Roque R, Nicolini H. Brain Gene Expression Profiling of Individuals With Dual Diagnosis Who Died by Suicide. Journal Of Dual Diagnosis 2019, 16: 177-190. PMID: 31774731, DOI: 10.1080/15504263.2019.1692160.Peer-Reviewed Original ResearchConceptsSubstance use disordersMood disordersDual diagnosisUse disordersMental comorbiditiesGene expression profilesMental disordersSingle disorderCell type enrichmentAdverse clinical outcomesGlial-specific markersMore mental disordersExpression profilesDorsolateral prefrontal cortexClinical outcomesGABAergic neurotransmissionGlial markersHigh riskDisorder patientsComorbiditiesSuicidal behaviorPrefrontal cortexGene expression profilingSynaptic genesDisorders
2023
Sex differences in the polygenic architecture of hearing problems in adults
De Angelis F, Zeleznik O, Wendt F, Pathak G, Tylee D, De Lillo A, Koller D, Cabrera-Mendoza B, Clifford R, Maihofer A, Nievergelt C, Curhan G, Curhan S, Polimanti R. Sex differences in the polygenic architecture of hearing problems in adults. Genome Medicine 2023, 15: 36. PMID: 37165447, PMCID: PMC10173489, DOI: 10.1186/s13073-023-01186-3.Peer-Reviewed Original ResearchConceptsPolygenic architectureRisk lociGenome-wide investigationLarge-scale genetic studiesTranscriptomic regulationGWAS findingsTranscriptomic associationsGene interactionsPotential roleRegulation analysisGenetic studiesInference analysisMillion Veteran ProgramHealth Professionals FollowMolecular pathwaysPolygenic riskPreventive screening programsMultivariate interaction analysisNovel insightsCentral nervous systemEnvironmental risk factorsSex-stratified analysesSex-specific analysesSex differencesMental health outcomes
2022
Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder
Wendt FR, Pathak GA, Deak JD, De Angelis F, Koller D, Cabrera-Mendoza B, Lebovitch DS, Levey DF, Stein MB, Kranzler HR, Koenen KC, Gelernter J, Huckins LM, Polimanti R. Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder. Molecular Psychiatry 2022, 27: 2206-2215. PMID: 35181757, PMCID: PMC9133008, DOI: 10.1038/s41380-022-01469-y.Peer-Reviewed Original Research
2019
Exploratory analysis of genetic variants influencing molecular traits in cerebral cortex of suicide completers
Rodríguez‐López M, Martínez‐Magaña J, Cabrera‐Mendoza B, Genis‐Mendoza A, García‐Dolores F, López‐Armenta M, Flores G, Vázquez‐Roque R, Nicolini H. Exploratory analysis of genetic variants influencing molecular traits in cerebral cortex of suicide completers. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2019, 183: 26-37. PMID: 31418530, DOI: 10.1002/ajmg.b.32752.Peer-Reviewed Original ResearchConceptsExpression quantitative trait lociQuantitative trait lociTrait lociExpression of genesGene expressionGenetic variantsMethylation quantitative trait lociGene expression regulationExpression regulationCandidate genetic variantsDNA methylationMolecular traitsTranscription factorsEnhancer activityCell organizationRegulatory mechanismsGenetic factorsGenotype dataMultiple biological systemsLociGenesExpressionBiological systemsRegulationVariants