2023
Chemoimmunotherapy for Untreated Lung Cancer Brain Metastases: Systemic Before Local Therapy?
Lu B, Goldberg S. Chemoimmunotherapy for Untreated Lung Cancer Brain Metastases: Systemic Before Local Therapy? Journal Of Clinical Oncology 2023, 41: 4462-4464. PMID: 37603819, DOI: 10.1200/jco.23.01323.Peer-Reviewed Original ResearchThe Association Between Civil Legal Needs After Incarceration, Psychosocial Stress, and Cardiovascular Disease Risk Factors
Lu B, Thomas K, Feder S, Bhandary-Alexander J, Aminawung J, Puglisi L. The Association Between Civil Legal Needs After Incarceration, Psychosocial Stress, and Cardiovascular Disease Risk Factors. The Journal Of Law, Medicine & Ethics 2023, 51: 856-864. PMID: 38477262, PMCID: PMC10937168, DOI: 10.1017/jme.2024.26.Peer-Reviewed Original ResearchConceptsLegal needsCardiovascular disease risk factorsDisease risk factorsCivil legal needsIncarcerated peoplePsychosocial stressAssociated with psychosocial stressRelease peoplePublic benefitsRisk factorsHigh blood pressureHealthcare accessRe-entryHigh cholesterolIncarcerationBlood pressureNeedsAssociationPeoplePsychosocialHealthcareSocietyDebtCardiovascularHealth
2021
Spatially resolved analysis of the T cell immune contexture in lung cancer-associated brain metastases
Lu BY, Gupta R, Aguirre-Ducler A, Gianino N, Wyatt H, Ribeiro M, Chiang VL, Contessa JN, Adeniran AJ, Jilaveanu LB, Kluger HM, Schalper KA, Goldberg SB. Spatially resolved analysis of the T cell immune contexture in lung cancer-associated brain metastases. Journal For ImmunoTherapy Of Cancer 2021, 9: e002684. PMID: 34670827, PMCID: PMC8529973, DOI: 10.1136/jitc-2021-002684.Peer-Reviewed Original ResearchConceptsPrimary lung tumorsT cell subsetsMajor T cell subsetsMultiplexed quantitative immunofluorescenceLung tumorsT cellsCoinhibitory receptorsTim-3Cell subsetsBrain metastasesQuantitative immunofluorescenceHigh LAG-3 expressionTumor PD-L1 expressionPD-L1 protein expressionLymphocyte activation gene-3Low T cell infiltrationHigh TIM-3Major clinicopathological variablesPD-L1 expressionLAG-3 expressionT cell infiltrationTumor-infiltrating lymphocytesLonger overall survivalCell death 1Tumor immune microenvironment
2020
PD-1/PD-L1 Blockers in NSCLC Brain Metastases: Challenging Paradigms and Clinical Practice
Eguren-Santamaria I, Sanmamed MF, Goldberg SB, Kluger HM, Idoate MA, Lu B, Corral J, Schalper KA, Herbst RS, Gil-Bazo I. PD-1/PD-L1 Blockers in NSCLC Brain Metastases: Challenging Paradigms and Clinical Practice. Clinical Cancer Research 2020, 26: 4186-4197. PMID: 32354698, DOI: 10.1158/1078-0432.ccr-20-0798.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerImmune checkpoint inhibitorsAnti-PD-1/PD-L1 antibodiesAdvanced non-small cell lung cancerNSCLC brain metastasesBrain metastasesPD-L1 antibodiesAnti-PD-1/PD-L1 agentsPD-1/PD-L1 blockersActive central nervous system (CNS) involvementHigh PD-L1 expressionAnti-PD-1/PD-L1 drugsCentral nervous system involvementPivotal phase III trialsActive brain metastasesCNS response ratesPD-L1 agentsPD-L1 blockersSystemic therapy combinationsNervous system involvementPD-L1 expressionPhase III trialsSubset of patientsCell lung cancerPD-L1 drugs
2018
Heterogeneity within the PF-EPN-B ependymoma subgroup
Cavalli FMG, Hübner JM, Sharma T, Luu B, Sill M, Zapotocky M, Mack SC, Witt H, Lin T, Shih DJH, Ho B, Santi M, Emery L, Hukin J, Dunham C, McLendon RE, Lipp ES, Gururangan S, Grossbach A, French P, Kros JM, van Veelen MC, Rao AAN, Giannini C, Leary S, Jung S, Faria CC, Mora J, Schüller U, Alonso MM, Chan JA, Klekner A, Chambless LB, Hwang EI, Massimino M, Eberhart CG, Karajannis MA, Lu B, Liau LM, Zollo M, Ferrucci V, Carlotti C, Tirapelli DPC, Tabori U, Bouffet E, Ryzhova M, Ellison DW, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Pfister SM, Taylor MD, Aldape K, Pajtler KW, Kool M, Ramaswamy V. Heterogeneity within the PF-EPN-B ependymoma subgroup. Acta Neuropathologica 2018, 136: 227-237. PMID: 30019219, PMCID: PMC6373486, DOI: 10.1007/s00401-018-1888-x.Peer-Reviewed Original ResearchConceptsGenome-wide methylation dataPFA ependymomasChromosome 13q lossDNA methylation profilingGene expression profilesGene expression profilingCopy number profilingBroad copy-number aberrationsCopy number alterationsCopy number aberrationsMethylation profilingExpression profilingExpression profilesDistinct molecular variantsMethylation dataIntegrated analysisDistinct molecular subtypesMolecular variantsProfilingT-SNE analysisMolecular heterogeneityRobust markerPF-EPNNovel markerBiological heterogeneity
2016
Splice site mutation in factor X gene manifesting as severe intracranial haemorrhage in neonatal period with a challenging treatment course
Madhusoodhan P, Lu B, Chen J, Jones C, Meyer J, Roman E, Nardi M, Carroll W, Bhatla T. Splice site mutation in factor X gene manifesting as severe intracranial haemorrhage in neonatal period with a challenging treatment course. Haemophilia 2016, 23: e138-e140. PMID: 27995737, DOI: 10.1111/hae.13138.Peer-Reviewed Original ResearchFacial manifestations of Epstein–Barr virus‐related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations
Lu B, Kojima L, Huang M, Friedmann A, Ferry J, Weinstein H. Facial manifestations of Epstein–Barr virus‐related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations. Pediatric Blood & Cancer 2016, 63: 2042-2045. PMID: 27392033, DOI: 10.1002/pbc.26102.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaLymphoblastic leukemiaLymphoproliferative diseaseB-cell acute lymphoblastic leukemiaRight-sided facial swellingT-cell acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaHematopoietic transplantationMaintenance chemotherapyPrimary immunodeficiencyBilateral dacryoadenitisAtypical presentationFacial swellingLip lesionsNeither patientLymphoplasmacytic infiltrationT cellsFacial manifestationsFacial lesionsB cellsPatientsDe-escalationRemissionLeukemiaLesionsDecitabine enhances chemosensitivity of early T-cell precursor-acute lymphoblastic leukemia cell lines and patient-derived samples
Lu B, Thanawala S, Zochowski K, Burke M, Carroll W, Bhatla T. Decitabine enhances chemosensitivity of early T-cell precursor-acute lymphoblastic leukemia cell lines and patient-derived samples. Leukemia & Lymphoma 2016, 57: 1938-1941. PMID: 26726842, DOI: 10.3109/10428194.2015.1110747.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsAzacitidineBasic Helix-Loop-Helix Transcription FactorsCell Line, TumorCell SurvivalDecitabineDrug SynergismGene Expression Regulation, LeukemicHumansJurkat CellsMiceNeoplasm ProteinsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaReceptors, Interleukin-7Reverse Transcriptase Polymerase Chain ReactionXenograft Model Antitumor AssaysGenomic Characterization of Poorly Differentiated Neuroendocrine Carcinoma in a Pediatric Patient
Bhatla T, Dandekar S, Lu B, Wang J, Han E, Bitterman D, Jones C, Evensen N, Magid M, Meyer J, Carroll W. Genomic Characterization of Poorly Differentiated Neuroendocrine Carcinoma in a Pediatric Patient. Journal Of Pediatric Hematology/Oncology 2016, 38: e21-e25. PMID: 26558807, PMCID: PMC4681625, DOI: 10.1097/mph.0000000000000463.Peer-Reviewed Original ResearchConceptsNeuroendocrine carcinomaRare tumorPediatric patientsPoor-differentiated neuroendocrine carcinomasMediastinal neuroendocrine carcinomaPrimary neuroendocrine carcinomaStandard treatment approachLack of standardized treatment approachWhole-exome sequencingLOH regionsGenomic characterizationExome sequencingSomatic variantsHRAS geneTumor tissuesMolecular taxonomyGenomic landscapeSomatic mutationsTumorTreatment approachesTherapeutic targetInvestigation of therapeutic targetsCarcinomaPatientsLOH
2014
Ovarian Vein Thrombophlebitis Related to Large Uterine Myoma
Haynes M, Lu B, Winkel A. Ovarian Vein Thrombophlebitis Related to Large Uterine Myoma. Obstetrics And Gynecology 2014, 123: 450-453. PMID: 24413242, DOI: 10.1097/aog.0000000000000091.Peer-Reviewed Original ResearchConceptsOvarian vein thrombophlebitisUterine myomaAbdominal painEvidence of venous stasisLeft ovarian veinSevere abdominal painComputed tomography scanRisk factors of pregnancyFactors of pregnancyNonpuerperal patientsAbdominal myomectomyNulligravid womenEnlarged uterusOvarian veinVenous compressionPostoperative diseaseTomography scanUnusual caseVenous stasisMyomaRisk factorsThrombophlebitisPatientsIntraluminal thrombusThrombosis formation
2013
Design, Evaluation, and Dissemination of a Plastic Syringe Clip to Improve Dosing Accuracy of Liquid Medications
Spiegel G, Dinh C, Gutierrez A, Lukomnik J, Lu B, Shah K, Slough T, Yeh P, Mirabal Y, Gray L, Marton S, Adler M, Schutze G, Wickham H, Oden M, Richards-Kortum R. Design, Evaluation, and Dissemination of a Plastic Syringe Clip to Improve Dosing Accuracy of Liquid Medications. Annals Of Biomedical Engineering 2013, 41: 1860-1868. PMID: 23471817, DOI: 10.1007/s10439-013-0780-z.Peer-Reviewed Original Research