2018
Heterogeneity within the PF-EPN-B ependymoma subgroup
Cavalli FMG, Hübner JM, Sharma T, Luu B, Sill M, Zapotocky M, Mack SC, Witt H, Lin T, Shih DJH, Ho B, Santi M, Emery L, Hukin J, Dunham C, McLendon RE, Lipp ES, Gururangan S, Grossbach A, French P, Kros JM, van Veelen MC, Rao AAN, Giannini C, Leary S, Jung S, Faria CC, Mora J, Schüller U, Alonso MM, Chan JA, Klekner A, Chambless LB, Hwang EI, Massimino M, Eberhart CG, Karajannis MA, Lu B, Liau LM, Zollo M, Ferrucci V, Carlotti C, Tirapelli DPC, Tabori U, Bouffet E, Ryzhova M, Ellison DW, Merchant TE, Gilbert MR, Armstrong TS, Korshunov A, Pfister SM, Taylor MD, Aldape K, Pajtler KW, Kool M, Ramaswamy V. Heterogeneity within the PF-EPN-B ependymoma subgroup. Acta Neuropathologica 2018, 136: 227-237. PMID: 30019219, PMCID: PMC6373486, DOI: 10.1007/s00401-018-1888-x.Peer-Reviewed Original ResearchConceptsGenome-wide methylation dataPFA ependymomasChromosome 13q lossDNA methylation profilingGene expression profilesGene expression profilingCopy number profilingBroad copy-number aberrationsCopy number alterationsCopy number aberrationsMethylation profilingExpression profilingExpression profilesDistinct molecular variantsMethylation dataIntegrated analysisDistinct molecular subtypesMolecular variantsProfilingT-SNE analysisMolecular heterogeneityRobust markerPF-EPNNovel markerBiological heterogeneity
2016
Facial manifestations of Epstein–Barr virus‐related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations
Lu B, Kojima L, Huang M, Friedmann A, Ferry J, Weinstein H. Facial manifestations of Epstein–Barr virus‐related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations. Pediatric Blood & Cancer 2016, 63: 2042-2045. PMID: 27392033, DOI: 10.1002/pbc.26102.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaLymphoblastic leukemiaLymphoproliferative diseaseB-cell acute lymphoblastic leukemiaRight-sided facial swellingT-cell acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaHematopoietic transplantationMaintenance chemotherapyPrimary immunodeficiencyBilateral dacryoadenitisAtypical presentationFacial swellingLip lesionsNeither patientLymphoplasmacytic infiltrationT cellsFacial manifestationsFacial lesionsB cellsPatientsDe-escalationRemissionLeukemiaLesions