Decitabine enhances chemosensitivity of early T-cell precursor-acute lymphoblastic leukemia cell lines and patient-derived samples
Lu B, Thanawala S, Zochowski K, Burke M, Carroll W, Bhatla T. Decitabine enhances chemosensitivity of early T-cell precursor-acute lymphoblastic leukemia cell lines and patient-derived samples. Leukemia & Lymphoma 2016, 57: 1938-1941. PMID: 26726842, DOI: 10.3109/10428194.2015.1110747.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsAzacitidineBasic Helix-Loop-Helix Transcription FactorsCell Line, TumorCell SurvivalDecitabineDrug SynergismGene Expression Regulation, LeukemicHumansJurkat CellsMiceNeoplasm ProteinsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaReceptors, Interleukin-7Reverse Transcriptase Polymerase Chain ReactionXenograft Model Antitumor AssaysGenomic Characterization of Poorly Differentiated Neuroendocrine Carcinoma in a Pediatric Patient
Bhatla T, Dandekar S, Lu B, Wang J, Han E, Bitterman D, Jones C, Evensen N, Magid M, Meyer J, Carroll W. Genomic Characterization of Poorly Differentiated Neuroendocrine Carcinoma in a Pediatric Patient. Journal Of Pediatric Hematology/Oncology 2016, 38: e21-e25. PMID: 26558807, PMCID: PMC4681625, DOI: 10.1097/mph.0000000000000463.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, NeuroendocrineChild, PreschoolDNA Mutational AnalysisFemaleGenome, HumanHumansMediastinal NeoplasmsReverse Transcriptase Polymerase Chain ReactionConceptsNeuroendocrine carcinomaRare tumorPediatric patientsPoor-differentiated neuroendocrine carcinomasMediastinal neuroendocrine carcinomaPrimary neuroendocrine carcinomaStandard treatment approachLack of standardized treatment approachWhole-exome sequencingLOH regionsGenomic characterizationExome sequencingSomatic variantsHRAS geneTumor tissuesMolecular taxonomyGenomic landscapeSomatic mutationsTumorTreatment approachesTherapeutic targetInvestigation of therapeutic targetsCarcinomaPatientsLOH