2024
Psilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic
Back A, Freeman-Young T, Morgan L, Sethi T, Baker K, Myers S, McGregor B, Harvey K, Tai M, Kollefrath A, Thomas B, Sorta D, Kaelen M, Kelmendi B, Gooley T. Psilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e2449026. PMID: 39636638, PMCID: PMC11621983, DOI: 10.1001/jamanetworkopen.2024.49026.Peer-Reviewed Original ResearchConceptsAdvanced practice practitionersSymptoms of depressionMontgomery-Asberg Depression Rating ScalePosttraumatic stress disorderSymptoms of burnoutMontgomery-Asberg Depression Rating Scale scoreSymptoms of posttraumatic stress disorderFrontline carePsilocybin therapyRandomized clinical trialsSevere symptoms of depressionMental health diagnosesScore changesImprove symptoms of depressionCOVID-19 pandemicPCL-5Intention-to-treat principleMedication sessionsDepression Rating ScalePCL-5 scoresPsychological morbidityHealth diagnosisMain OutcomesPractice practitionersUS cliniciansNovel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence
Sippel L, Hamblen J, Kelmendi B, Alpert J, Carpenter L, Grzenda A, Kraguljac N, McDonald W, Rodriguez C, Widge A, Nemeroff C, Schnurr P, Holtzheimer P, Biomarkers and Treatments T. Novel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence. American Journal Of Psychiatry 2024, 181: 1045-1058. PMID: 39616450, DOI: 10.1176/appi.ajp.20230950.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderPathophysiology of posttraumatic stress disorderNon-trauma-focused psychotherapyTrauma-focused psychotherapySomatic treatment approachesEvidence-based treatmentsAntidepressant medicationSomatic treatmentsPsychiatric disordersSomatic interventionsTranscranial magnetic stimulationPsychotherapyMagnetic stimulationTreatment approachesDisordersRecommended first-line treatmentAdultsFirst-line treatmentMedicationMechanism of actionMonotherapy strategySalienceSpecific treatmentEvidenceMechanisms of therapeutic change after psychedelic treatment in OCD
Maloney G, Ching T, Kichuk S, Pittenger C, Kelmendi B. Mechanisms of therapeutic change after psychedelic treatment in OCD. Psychiatry Research 2024, 336: 115907. PMID: 38615521, PMCID: PMC11190873, DOI: 10.1016/j.psychres.2024.115907.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMechanisms of therapeutic changeAversive eventsImagery rescriptingPsychedelic treatmentPsychotherapeutic treatmentPsychotherapeutic frameworkSymptom reductionTherapeutic changePsychotherapyNegative emotionsPsychological mechanismsCore beliefsPilot dataNovel treatmentRescriptingEmotionsDisordersSymptomsReprocessingTreatmentBeliefsResistance to first-lineIndividualsIntervention
2023
Frontopolar multifocal transcranial direct current stimulation reduces conditioned fear reactivity during extinction training: A pilot randomized controlled trial
Adams T, Kelmendi B, George J, Forte J, Hubert T, Wild H, Rippey C, Pittenger C. Frontopolar multifocal transcranial direct current stimulation reduces conditioned fear reactivity during extinction training: A pilot randomized controlled trial. Neurobiology Of Learning And Memory 2023, 205: 107825. PMID: 37699439, PMCID: PMC10872945, DOI: 10.1016/j.nlm.2023.107825.Peer-Reviewed Original ResearchConceptsTranscranial direct current stimulationSkin conductance responsesExtinction trainingDirect current stimulationExtinction learningCurrent stimulationReturn of fearFear extinction paradigmInhibition of fearFear extinction learningExposure-based therapyTreatment of anxietyFear inhibitionThreat cuesSafety learningExtinction paradigmFear reactivityFear processingConductance responsesExtinction trialsFunctional connectivityElectrodermal activityMixed ANOVARelated disordersAnxiety